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Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab′)2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels*

Autor: Lothar Daum, Mark A. Miller, Gregory Hicklin, John C. Marshall, Christopher J. Doig, Edward A. Panacek, Leah Teoh, William T. Barchuk, Lori Van Meter, Martin Kaul, Rodger D. MacArthur, Timothy E Albertson, David H. Johnson, Steven Fischkoff, Stanley Lemeshow, Steven B. Johnson

Publikováno v: Critical Care Medicine. 32:2173-2182

Objective: To evaluate whether administration of afelimomab, an anti-tumor necrosis factor F(ab')2 monoclonal antibody fragment, would reduce 28-day all-cause mortality in patients with severe sepsis and elevated serum levels of IL-6. Design: Prospec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31daac71acd7f0379cbd608cd3cac193
https://doi.org/10.1097/01.ccm.0000145229.59014.6c

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A multicenter, open-label, prospective, randomized, dose-ranging pharmacokinetic study of the anti-TNF-α antibody afelimomab in patients with sepsis syndrome

Autor: Charles J. Fisher, Raja B. Velagapudi, Travis Ellison, Bruce Meyers, Mark A. Munger, Leah Teoh, William T. Barchuk, Steven Fischkoff, James Gallagher, Bruce Sherman

Publikováno v: Intensive Care Medicine. 27:1169-1178

Objective: To investigate the pharmacokinetics and safety of afelimomab, a murine antibody fragment against human tumor necrosis factor (TNF)-α in patients with sepsis. Design: Multicenter, randomized, open-label, placebo-controlled phase I/II clini

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e9acf0ca2a0de9b96b7bdd4714ce4d5
https://doi.org/10.1007/s001340100973

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Missing radiographic data handling in randomized clinical trials in rheumatoid arthritis

Autor: Gary G. Koch, Lixia Jiao, Hui Quan, Lynn Wei, Leah Teoh, Xiaohong Huang

Publikováno v: Journal of biopharmaceutical statistics. 23(6)

In recent years, there has been increasing interest in compounds that have potential to slow down the structural joint damage in rheumatoid arthritis (RA) patients. Radiographs are instrumental in assessing structure damage in RA. Radiographic analys

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8a1135d2162b6d69f65cf72c486d287
https://pubmed.ncbi.nlm.nih.gov/24138441

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Adequacy of early empiric antibiotic treatment and survival in severe sepsis: experience from the MONARCS trial

Autor: Mark A. Miller, William T. Barchuk, Rodger D. MacArthur, Edward A. Panacek, Timothy E Albertson, David Johnson, Leah Teoh

Publikováno v: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 38(2)

As part of the Monoclonal Anti-TNF: A Randomized Controlled Sepsis (MONARCS) trial, which enrolled patients with suspected sepsis, we sought to determine whether adequate antibiotic therapy was associated with a decreased mortality rate. The study en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58904b4da0c49d8afb95ab4e3a9028c9
https://pubmed.ncbi.nlm.nih.gov/14699463

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Akademický článek

Efficacy and safety of the monoclonal anti-tumor necrosis factor antibody F(ab')2 fragment afelimomab in patients with severe sepsis and elevated interleukin-6 levels.

Autor: Edward A Panacek, John C Marshall, Timothy E Albertson, David H Johnson, Steven Johnson, Rodger D MacArthur, Mark Miller, William T Barchuk, Steven Fischkoff, Martin Kaul, Leah Teoh, Lori Van Meter, Lothar Daum, Stanley Lemeshow, Gregory Hicklin, Christopher Doig

Publikováno v: Critical Care Medicine; Nov2004, Vol. 32 Issue 11, p2173-2182, 10p

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