Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Leah S. Imlay"'
Autor:
Leah S. Imlay, Aloysus K. Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno Crespo-Fernandez, Bruce A. Posner, Francisco-Javier Gamo, Jake Baum, Elizabeth A. Winzeler, Benoît Laleu, Joseph M. Ready, Margaret A. Phillips
Publikováno v:
ACS Infectious Diseases. 9:527-539
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::537f1ef2dacdeb367b99fd7da88c7d0b
https://doi.org/10.1021/acsinfecdis.2c00527
https://doi.org/10.1021/acsinfecdis.2c00527
Autor:
Leah S. Imlay, Aloysus K. Lawong, Suraksha Gahalawat, Ashwani Kumar, Chao Xing, Nimisha Mittal, Sergio Wittlin, Alisje Churchyard, Hanspeter Niederstrasser, Benigno Crespo-Fernandez, Bruce Posner, Francisco Javier Gamo, Jake Baum, Elizabeth A. Winzeler, Benoît Laleu, Joseph M. Ready, Margaret A. Phillips
Current malaria treatments are threatened by drug resistance and new drugs are urgently needed. In a phenotypic screen for new antimalarials, we identified (S)-SW228703 ((S)-SW703), a tyrosine amide with asexual blood and liver stage activity and a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2e075d7b4525241704c6d99d7df97273
https://doi.org/10.1101/2022.10.16.512381
https://doi.org/10.1101/2022.10.16.512381
Autor:
David J. Meyers, Audrey R. Odom, Caren L. Freel Meyers, Christopher M. Armstrong, Leah S. Imlay
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:5511-5519
There is a pressing need for new antimicrobial therapies to combat globally important drug-resistant human pathogens, including Plasmodium falciparum malarial parasites, Mycobacterium tuberculosis , and Gram-negative bacteria, including Escherichia c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ad2663e89a86d70bb4b5c838f248c9
https://doi.org/10.1128/aac.00602-15
https://doi.org/10.1128/aac.00602-15
Autor:
Rachel L. Edwards, Neil G. Berry, Leah S. Imlay, Mary Clare Masters, Christopher M. Armstrong, Ting Li, Kathryn E. Price, Katherine M. Mann, Christina L. Stallings, Lucy X. Li, Paul M. O'Neill, Audrey R. Odom
Publikováno v:
ACS Infectious Diseases. 1:157-167
As resistance to current therapies spreads, novel antimalarials are urgently needed. In this work, we examine the potential for therapeutic intervention via the targeting of Plasmodium IspD (2-C-methyl-D-erythritol 4-phosphate cytidyltransferase), th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d689ae80d54fb555e24205b69dc7a46
https://doi.org/10.1021/id500047s
https://doi.org/10.1021/id500047s
Autor:
Audrey R. Odom, Leah S. Imlay
Publikováno v:
Current Clinical Microbiology Reports. 1:37-50
Apicomplexan parasites include some of the most prevalent and deadly human pathogens. Novel antiparasitic drugs are urgently needed. Synthesis and metabolism of isoprenoids may present multiple targets for therapeutic intervention. The apicoplast-loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17372361dfb41642c498b56362652b69
https://doi.org/10.1007/s40588-014-0006-7
https://doi.org/10.1007/s40588-014-0006-7
Autor:
Kathryn E. Price, Leah S. Imlay, Niraj H. Tolia, Paul M. O'Neill, Natalie J. Roberts, Alexandre S. Lawrenson, Chandra Pidathala, Neil G. Berry, Marwa O. Mikati, Christopher M. Armstrong, Jooyoung Park, Dana M. Hodge, Raman Sharma, Audrey R. Odom John
Publikováno v:
Scientific Reports
The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-through
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d191188f635cd9e7e5d1d0059f7e34e7
http://europepmc.org/articles/PMC5114681
http://europepmc.org/articles/PMC5114681