Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Leah S. Hohman"'
Autor:
Patrick B. Walter, Leah S. Hohman, Andrew Rokeby, Julian J. Lum, Robert Hagar, Lisa Lavrisha, Augusta Saulys, Frans A. Kuypers, Elliott Vichinsky, Claudia R. Morris
Publikováno v:
Complementary Therapies in Medicine, Vol 70, Iss , Pp 102856- (2022)
Objectives: L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential activation of autophagy as a previously unexplored mechanism-of-benefit. Desig
Externí odkaz:
https://doaj.org/article/560b1ca54ac24f2ea448737dead2bb32
Autor:
Leah S Hohman, Zhirong Mou, Matheus B Carneiro, Gabriel Ferland, Rachel M Kratofil, Paul Kubes, Jude E Uzonna, Nathan C Peters
Publikováno v:
PLoS Pathogens, Vol 17, Iss 9, p e1009944 (2021)
Intracellular infection with the parasite Leishmania major features a state of concomitant immunity in which CD4+ T helper 1 (Th1) cell-mediated immunity against reinfection coincides with a chronic but sub-clinical primary infection. In this setting
Externí odkaz:
https://doaj.org/article/4c6912c0c3984579bab3f79f849cf3a1
Autor:
Leah S, Hohman, Lisa C, Osborne
Publikováno v:
Immunity. 55:1148-1150
A plethora of studies have established the importance of eosinophils in protective immunity against infections and in allergy. In this issue of Immunity, Ignacio et al. (2022) define a vital for eosinophils in coordinating a microbiota-epithelial-imm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aad6d009867725b9822fcace26afb2d8
https://doi.org/10.1016/j.immuni.2022.06.015
https://doi.org/10.1016/j.immuni.2022.06.015
Autor:
Leah S. Hohman, Lisa C. Osborne
Publikováno v:
Aging cell. 21(9)
Intestinal epithelial cells (IECs) serve as both a physical and an antimicrobial barrier against the microbiota, as well as a conduit for signaling between the microbiota and systemic host immunity. As individuals age, the balance between these syste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9117a788af81a80051af930264abc5eb
https://pubmed.ncbi.nlm.nih.gov/36000805
https://pubmed.ncbi.nlm.nih.gov/36000805
Autor:
Leah S. Hohman, Nathan C. Peters
Publikováno v:
Trends in Parasitology. 35:423-435
The generation of an efficacious vaccine that elicits protective CD4+ T cell-mediated immunity has been elusive. The lack of a vaccine against the Leishmania parasite is particularly perplexing as infected individuals acquire life-long immunity to re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da67ada499dcaf0aed0e527d8204231d
https://doi.org/10.1016/j.pt.2019.04.002
https://doi.org/10.1016/j.pt.2019.04.002
Autor:
Nathan C. Peters, Gabriel Ferland, Leah S. Hohman, Zhirong Mou, Paul Kubes, Jude E. Uzonna, Rachel M. Kratofil, Matheus B. H. Carneiro
Publikováno v:
PLoS Pathogens
PLoS Pathogens, Vol 17, Iss 9, p e1009944 (2021)
PLoS Pathogens, Vol 17, Iss 9, p e1009944 (2021)
Intracellular infection with the parasite Leishmania major features a state of concomitant immunity in which CD4+ T helper 1 (Th1) cell-mediated immunity against reinfection coincides with a chronic but sub-clinical primary infection. In this setting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::024923e3b012849f9e5121ac380d6538
https://pubmed.ncbi.nlm.nih.gov/34543348
https://pubmed.ncbi.nlm.nih.gov/34543348
Autor:
Patrick B. Walter, Leah S. Hohman, Andrew Rokeby, Julian J. Lum, Robert Hagar, Lisa Lavrisha, Augusta Saulys, Frans A. Kuypers, Elliott Vichinsky, Claudia R. Morris
Publikováno v:
Complementary therapies in medicine. 70
L-Glutamine was FDA-approved for sickle cell disease (SCD) in 2017, yet the mechanism(s)-of-action are poorly understood. This study investigates the potential activation of autophagy as a previously unexplored mechanism-of-benefit.Prospective, open-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12323b345898d641dd1e2209c31cf02c
https://pubmed.ncbi.nlm.nih.gov/35843474
https://pubmed.ncbi.nlm.nih.gov/35843474
Publikováno v:
Methods. 127:45-52
Intra-vital two-photon microscopy (2P-IVM) allows for in-situ investigation of tissue organization, cell behavior and the dynamic interactions between different cell types in their natural environment. This methodology has also expanded our understan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18cc46250f37451b3e7e79e729f0af5
https://doi.org/10.1016/j.ymeth.2017.04.012
https://doi.org/10.1016/j.ymeth.2017.04.012
Autor:
Leah S, Hohman, Nathan C, Peters
Publikováno v:
Trends in parasitology. 35(6)
The generation of an efficacious vaccine that elicits protective CD4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dd46f2affe3e62cedebe878ab94eacc1
https://pubmed.ncbi.nlm.nih.gov/31080088
https://pubmed.ncbi.nlm.nih.gov/31080088
Publikováno v:
The Journal of Immunology. 206:16.29-16.29
Leishmania is an appealing model organism to study CD4+ T cell-mediated protective immunity against phagosomal pathogens which features localized primary and secondary infection sites with defined innate and adaptive responses. Upon secondary challen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::31c0e564322bfb66307f66aff2f9bea3
https://doi.org/10.4049/jimmunol.206.supp.16.29
https://doi.org/10.4049/jimmunol.206.supp.16.29