Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Leah R. Reznikov"'
Publikováno v:
Physiological Reports, Vol 12, Iss 17, Pp n/a-n/a (2024)
Abstract Diving marine mammals are a diverse group of semi‐ to completely aquatic species. Some species are targets of conservation and rehabilitation efforts; other populations are permanently housed under human care and may contribute to clinical
Externí odkaz:
https://doaj.org/article/c2eaecc86deb4532bfeb22570840c817
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
The brainstem has long been recognized as the major respiratory control center, but it has become increasingly appreciated that areas upstream of the brainstem modulate respiration and airway defensive behaviors. This review aims to define the role o
Externí odkaz:
https://doaj.org/article/5efff2bd70034af0bb7541ba052b1de4
Autor:
Mariana Sponchiado, Amy Fagan, Luz Mata, Angelina L. Bonilla, Pedro Trevizan-Baú, Sreekala Prabhakaran, Leah R. Reznikov
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Introduction: Interleukin 13 (IL-13) is an important effector molecule in allergic asthma. IL-13-mediated mucin hypersecretion requires conversion of secretoglobin-positive club cells into goblet cells through suppression of forkhead box A2 (FOXA2) a
Externí odkaz:
https://doaj.org/article/f73cc8008194468fbe8dae20cb0c6689
Autor:
Mariana Sponchiado, Angelina L. Bonilla, Luz Mata, Kalene Jasso-Johnson, Yan-Shin J. Liao, Amy Fagan, Victor Moncada, Leah R. Reznikov
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Introduction: Club cells are precursors for mucus-producing goblet cells. Interleukin 1β (IL-1B) is an inflammatory mediator with pro-mucin activities that increases the number of mucus-producing goblet cells. IL-1B-mediated mucin production in alve
Externí odkaz:
https://doaj.org/article/502ca7429d6343a58d6a6058b45633bc
Autor:
Alexandria B. Marciante, Carter Lurk, Luz Mata, Jada Lewis, Leah R. Reznikov, Gordon S. Mitchell
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Rationale: Although sleep apnea occurs in over 50% of individuals with Alzheimer’s Disease (AD) or related tauopathies, little is known concerning the potential role of tauopathy in the pathogenesis of sleep apnea. Here, we tested the hypotheses th
Externí odkaz:
https://doaj.org/article/26bcfa8ae95e4f03b124ee314126cac6
Autor:
Kalina R. Atanasova, Leah R. Reznikov
Publikováno v:
Respiratory Research, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Mucus secretion and mucociliary transport are essential defense mechanisms of the airways. Deviations in mucus composition and secretion can impede mucociliary transport and elicit airway obstruction. As such, mucus abnormalities are hallmar
Externí odkaz:
https://doaj.org/article/e65dcd6a44004b33b78740422d9233fa
Autor:
Shin-Ping Kuan, Yan-Shin J. Liao, Katelyn M. Davis, Jonathan G. Messer, Jasenka Zubcevic, J. Ignacio Aguirre, Leah R. Reznikov
Publikováno v:
iScience, Vol 19, Iss , Pp 737-748 (2019)
Summary: Prolonged heat and sea salt aerosols pose a challenge for the mammalian airway, placing the protective airway surface liquid (ASL) at risk for desiccation. Thus, mammals inhabiting salt marshes might have acquired adaptations for ASL regulat
Externí odkaz:
https://doaj.org/article/6e86cc7c3a5d4ac7970e4a0ea70583b9
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Transient receptor potential melastatin 3 channel (TRPM3) is a calcium-permeable nonselective cation channel that plays an important role in modulating glucose homeostasis in the pancreatic beta cells. However, how TRPM3 is regulated under physiologi
Externí odkaz:
https://doaj.org/article/896cd094d4ea4f01a03208ba605c762e
Autor:
Mariana Sponchiado, Yan‐Shin Liao, Kalina R. Atanasova, Emily N. Collins, Veronica Schurmann, Laura Bravo, Leah R. Reznikov
Publikováno v:
Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021)
Abstract Substance P (SP) is a tachykinin that regulates airway mucous secretion in both health and disease. Our study aimed to determine whether overexpression of SP without pre‐existing inflammation was sufficient to induce changes in mucin secre
Externí odkaz:
https://doaj.org/article/9d542949364441318bc0da7b9f54ed37
Autor:
David K. Meyerholz, Amanda P. Beck, J. Adam Goeken, Mariah R. Leidinger, Georgina K. Ofori-Amanfo, Hannah C. Brown, Thomas R. Businga, David A. Stoltz, Leah R. Reznikov, Heather A. Flaherty
Publikováno v:
BMC Research Notes, Vol 11, Iss 1, Pp 1-5 (2018)
Abstract Objective Mucin is an important parameter for detection and assessment in studies of airway disease including asthma and cystic fibrosis. Histochemical techniques are often used to evaluate mucin in tissues sections. Periodic acid Schiff (PA
Externí odkaz:
https://doaj.org/article/cf082fa736564bd1910541e78568d678