Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leah R. Brooks"'
Publikováno v:
Clinical Pharmacology in Drug Development. 11:502-515
Repository corticotropin injection (RCI; Acthar Gel) is a naturally sourced complex mixture of adrenocorticotropic hormone (ACTH) analogs and other pituitary peptides. This phase 1, single-center, open-label, randomized parallel study directly compar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61bd92dd0edfab44d1be9eb0ce8b5348
https://doi.org/10.1002/cpdd.1020
https://doi.org/10.1002/cpdd.1020
Publikováno v:
Clinical Pharmacology in Drug Development
The pharmacokinetics (PK) and pharmacodynamics (PD) of clinically relevant doses of repository corticotropin injection (Acthar Gel) and synthetic ACTH1‐24 depot have not been fully characterized. We compared the steroidogenic exposure of repository
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::529973090af0f4b51a42c7d0b58232f8
http://europepmc.org/articles/PMC8359281
http://europepmc.org/articles/PMC8359281
Publikováno v:
Journal of Receptors and Signal Transduction. 41:425-433
To compare the binding and agonistic activity of ActharActhar Gel and synthetic MCR agonists exhibited the highest binding at MC1R, lowest binding at MC5R, and moderate binding at MC3R and MC4R. Acthar Gel stimulated the production of cAMP in all 5 M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b60a163c2c226e01fc725b6bc37e3f1a
https://doi.org/10.1080/10799893.2020.1818094
https://doi.org/10.1080/10799893.2020.1818094
Autor:
Leah R Brooks, Heide L Pals, Courtney L Enix, Rachel A Woolaver, Evan D Paul, Christopher A Lowry, Pei-San Tsai
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101420 (2014)
Functionally heterogeneous populations of serotonergic neurons, located within the dorsal raphe nucleus (DR), play a role in stress-related behaviors and neuropsychiatric illnesses such as anxiety and depression. Abnormal development of these neurons
Externí odkaz:
https://doaj.org/article/c77c5ed4444148a1b44ae38aa2b452e0
Autor:
Teresa E Foley, Leah R Brooks, Lori J Gilligan, Paul R Burghardt, Lauren G Koch, Steven L Britton, Monika Fleshner
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45415 (2012)
In order to further understand the genetic basis for variation in inherent (untrained) exercise capacity, we examined the brains of 32 male rats selectively bred for high or low running capacity (HCR and LCR, respectively). The aim was to characteriz
Externí odkaz:
https://doaj.org/article/4d085bf7eb8d4209bc52706d8a6b45c2
Autor:
Samuel C. Rich, Courtney L. Enix, Jinno A. Magno, Christopher A. Lowry, Leah R. Brooks, Pei-San Tsai
Publikováno v:
Behavioural Brain Research. 264:74-81
Serotonergic neurons in the dorsal raphe nucleus (DR) are organized in anatomically distinct subregions that form connections with specific brain structures to modulate diverse behaviors, including anxiety-like behavior. It is unclear if the function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45949e67d96f7d8d8a8cf91159a1d5f3
https://doi.org/10.1016/j.bbr.2014.01.053
https://doi.org/10.1016/j.bbr.2014.01.053
Autor:
Lauren G. Koch, Teresa E. Foley, Paul R. Burghardt, Steven L. Britton, Lori J. Gilligan, Leah R. Brooks, Monika Fleshner
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45415 (2012)
PLoS ONE
PLoS ONE
In order to further understand the genetic basis for variation in inherent (untrained) exercise capacity, we examined the brains of 32 male rats selectively bred for high or low running capacity (HCR and LCR, respectively). The aim was to characteriz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e78c1e7715499f2fb62ac2251da36ba
http://europepmc.org/articles/PMC3444461?pdf=render
http://europepmc.org/articles/PMC3444461?pdf=render
Publikováno v:
Frontiers in neuroendocrinology. 32(1)
Fibroblast growth factor (FGF) signaling is pivotal to the formation of numerous central regions. Increasing evidence suggests FGF signaling also directs the development of the neuroendocrine hypothalamus, a collection of neuroendocrine neurons origi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bc8fdf8e20ae933a3f2e82d3a18e59
https://pubmed.ncbi.nlm.nih.gov/21129392
https://pubmed.ncbi.nlm.nih.gov/21129392
Oxytocin (OT) is a nonapeptide essential for maternal care. The development of the OT neuroendocrine system is a multi-step process dependent on the action of many transcription factors, but upstream signaling molecules regulating this process are st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408d2c2cc5775923165d4e2a6f6acb40
https://europepmc.org/articles/PMC3093295/
https://europepmc.org/articles/PMC3093295/
Publikováno v:
Psychopharmacology. 199(2)
Although selective 5-HT reuptake inhibitors (SSRIs) can reduce anxiety after chronic treatment, acute SSRI administration is associated with an increase in anxiety consistent with an acute increase in 5-HT neurotransmission. Exercise is anxiolytic in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c4bc5575a3a653a9ef1b4af3bd2f720
https://pubmed.ncbi.nlm.nih.gov/18454279
https://pubmed.ncbi.nlm.nih.gov/18454279