Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Leah N Makley"'
Autor:
Ariel M Alperstein, Kathleen S Molnar, Sidney S Dicke, Kieran M Farrell, Leah N Makley, Martin T Zanni, Usha P Andley
Publikováno v:
PLoS ONE, Vol 16, Iss 9, p e0257098 (2021)
αB-crystallin is a small heat shock protein that forms a heterooligomeric complex with αA-crystallin in the ocular lens. It is also widely distributed in tissues throughout the body and has been linked with neurodegenerative diseases such as Alzhei
Externí odkaz:
https://doaj.org/article/4c2942701ef94b0dad0b814255bade00
Autor:
Delaney Osborn, Taia S. Wu, Jennifer N. Rauch, Oleta T. Johnson, Leah N. Makley, Jason E. Gestwicki, Heather A. Carlson, Phani Ghanakota, Tomasz Cierpicki
Publikováno v:
Bioorg Med Chem
Destabilizing mutations in small heat shock proteins (sHsps) are linked to multiple diseases; however, sHsps are conformationally dynamic, lack enzymatic function and have no endogenous chemical ligands. These factors render sHsps as classically “u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a260c554f090626d85bbd89ea2ca23f5
https://doi.org/10.1016/j.bmc.2020.115990
https://doi.org/10.1016/j.bmc.2020.115990
Autor:
Jason E. Gestwicki, Bonnie Su, Douglas F. Covey, Leah N. Makley, Mingxing Qian, Kathleen S. Molnar, Usha P. Andley, Paul D. Hamilton, Yevgeniy Izrayelit, Bryan M. Dunyak, Brittney N. McGlasson-Naumann
Publikováno v:
Investigative ophthalmology & visual science, vol 60, iss 10
Investigative Ophthalmology & Visual Science
Investigative Ophthalmology & Visual Science
Author(s): Molnar, Kathleen S; Dunyak, Bryan M; Su, Bonnie; Izrayelit, Yevgeniy; McGlasson-Naumann, Brittney; Hamilton, Paul D; Qian, Mingxing; Covey, Douglas F; Gestwicki, Jason E; Makley, Leah N; Andley, Usha P | Abstract: PurposeWe previously iden
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::215706a07fd3d9d3773cd5219f21ba04
https://doi.org/10.1167/iovs.18-25647
https://doi.org/10.1167/iovs.18-25647
Autor:
Jason E. Gestwicki, Leah N. Makley
Publikováno v:
Chemical Biology & Drug Design. 81:22-32
Following sequencing and assembly of the human genome, the preferred methods for identification of new drug targets have changed dramatically. Modern tactics such as genome-wide association studies (GWAS) and deep sequencing are fundamentally differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f2b06a85010a8dd9e10ab56d9211f31
https://doi.org/10.1111/cbdd.12066
https://doi.org/10.1111/cbdd.12066
Autor:
Daniel R. Southworth, Jennifer N. Rauch, Sue-Ann Mok, Leah N. Makley, Eric Tse, Jason E. Gestwicki, Rebecca Freilich
Publikováno v:
Journal of molecular biology, vol 429, iss 1
Small heat shock proteins (sHsps) are a family of ATP-independent molecular chaperones that are important for binding and stabilizing unfolded proteins. In this task, the sHsps have been proposed to coordinate with ATP-dependent chaperones, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be8b056472329db337f49c2b3bfedfac
https://europepmc.org/articles/PMC5186407/
https://europepmc.org/articles/PMC5186407/
Publikováno v:
Acta Ophthalmologica. 94
ummary Cataracts are the leading cause of blindness in the world, currently treatable only with surgery. The molecular chaperone α-crystallin helps to maintain the transparency of the crystallin lens. The soluble fraction of this protein decreases w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90dc0faaa392b6b120aa48ed82e633bb
https://doi.org/10.1111/j.1755-3768.2016.0145
https://doi.org/10.1111/j.1755-3768.2016.0145
Autor:
Leah N. Makley, Susanne Wisén, Sidhartha M. Chafekar, Christopher G. Evans, Martin L. Duennwald, AnaLisa Echeverria, Jason E. Gestwicki, Gladis M. Walter, Andrea D. Thompson
Publikováno v:
ACS chemical biology, vol 7, iss 9
Nine neurodegenerative disorders are caused by the abnormal expansion of polyglutamine (polyQ) regions within distinct proteins. Genetic and biochemical evidence has documented that the molecular chaperone, heat shock protein 70 (Hsp70), modulates po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b0bc22003b2edc29e7dff607d1e65ae
https://doi.org/10.1021/cb300166p
https://doi.org/10.1021/cb300166p
Publikováno v:
ACS Chemical Biology. 7:791-796
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71405af7ba1db2adbff018a7df5b43f3
https://doi.org/10.1021/cb3001827
https://doi.org/10.1021/cb3001827
Autor:
Bryan M. Dunyak, Brittney McGlasson, Joshua W. Goldman, Rachel E. Klevit, Jason E. Gestwicki, Usha P. Andley, Thomas J. McQuade, Leah N. Makley, Kathryn A. McMenimen, Ponni Rajagopal, Andrea D. Thompson, Roger K. Sunahara, Brian T. DeVree
Publikováno v:
Science (New York, N.Y.), vol 350, iss 6261
A visionary approach to transparency Cataracts are the most common cause of vision loss, especially in our ever-increasing elderly population. Cataracts arise when crystallin, a major protein component of the eye lens, begins to aggregate, which caus
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a7a7b7f7d4d3fe4c43af11c63220ea8
https://escholarship.org/uc/item/12d1q82j
https://escholarship.org/uc/item/12d1q82j
Publikováno v:
Chem. Commun.. 47:529-531
A series of dihydropyridines were identified that have an effect on the accumulation of tau, an important target in Alzheimer's disease. The dihydropyridine collection was expanded using the Hantzsch multicomponent reaction to develop preliminary str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94ea564cb9487a672c0c50fa94969785
https://doi.org/10.1039/c0cc02253e
https://doi.org/10.1039/c0cc02253e