Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Leah M. Zorrilla"'
Autor:
Steffen Schneider, Mary E. Gilbert, Volker Strauss, M. Sue Marty, Sheri Lordi, Susan L. Makris, Bethany R. Hannas, Pragati S. Coder, Ann Blacker, Leah M. Zorrilla, Abby A. Li
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 106
Thyroid hormones (THs; T3 and T4) play a role in development of cardiovascular, reproductive, immune and nervous systems. Thus, interpretation of TH changes from rodent studies (during pregnancy, in fetuses, neonates, and adults) is critical in hazar
Autor:
Leah M. Zorrilla, Lisa S. Ortego, Ellen Mihaich, M. Sue Marty, Katie Coady, Steven L. Levine, Richard M. Green, Kun Don Yi, James R. Wheeler, Chris Borgert
Publikováno v:
Regulatory toxicology and pharmacology : RTP. 99
The endocrine system is responsible for growth, development, maintaining homeostasis and for the control of many physiological processes. Due to the integral nature of its signaling pathways, it can be difficult to distinguish endocrine-mediated adve
Autor:
Leah M. Zorrilla, Grace E. Kissling, Michael J. DeVito, Dave Malarkey, Greg Travlos, Alison H. Harrill, Chad R. Blystone, Keith R. Shockley, Susan J. Borghoff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cd2085b961aa5c80d4f0b975f1593790
https://doi.org/10.22427/ntp-rr-6
https://doi.org/10.22427/ntp-rr-6
Autor:
Leah M. Zorrilla, Christopher J. Borgert, Oliver Kroner, Michael G. Wade, John R. Fowle, Richard A. Becker, Melvin E. Andersen, Warren Casey, Michael P. Holsapple, Glen Van Der Kraak, Susan J. Borghoff, Lisa S. Ortego, James C. Lamb, M. Sue Marty, Daland R. Juberg, Thaddeus T. Schug, Katherine K. Coady, Ellen Mihaich, Colleen Toole, Brett Jones, Catherine Willett, Lori Rinckel, Thomas Hartung, Michael L. Dourson, L. Earl Gray, Jacqueline Patterson
Publikováno v:
ALTEX. 31:63-78
In 1996, the U.S. Congress passed the Food Quality Protection Act and amended the Safe Drinking Water Act (SDWA) requiring the U.S. Environmental Protection Agency (EPA) to implement a screening program to investigate the potential of pesticide chemi
Publikováno v:
Birth Defects Research Part B: Developmental and Reproductive Toxicology. 98:428-435
Two critical components of the validation of any in vivo screening assay are to demonstrate sensitivity and specificity. Although the Endocrine Disruptor Screening Program's Tier 1 Male and Female Pubertal Protocols have been shown to be sensitive as
Expression of Genes Associated with Apoptosis in the Porcine Corpus Luteum During the Oestrous Cycle
Publikováno v:
Reproduction in Domestic Animals. 48:755-761
The corpus luteum (CL) of the pig lacks luteolytic sensitivity (LS) to prostaglandin (PG) F-2α until after day 12 of the oestrous cycle, but the mechanisms underlying this phenomenon are poorly understood. As luteolysis involves apoptosis, we hypoth
Publikováno v:
Endocrine Toxicology ISBN: 9780429136856
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb4457ec07c5049cdcc31b7168383458
https://doi.org/10.3109/9781420093100-4
https://doi.org/10.3109/9781420093100-4
Autor:
Michael G. Narotsky, Deborah S. Best, Tammy E. Stoker, Jerome M. Goldman, Lori K. Davis, Leah M. Zorrilla, Ashley S. Murr, Melanie J.P. Fraites, Ralph L. Cooper
Publikováno v:
Reproductive Toxicology. 32:43-51
Atrazine (ATR) is an herbicide that exerts negative reproductive effects. We examined the effects of vehicle or ATR (1, 5, 20 and 100mg/kg-d), administered to Sprague-Dawley rats on gestational days 14-21, once daily or divided into two doses per day
Autor:
Angela R. Buckalew, Nicole S. Tinfo, Ralph L. Cooper, Susan C. Laws, Michelle G. Hotchkiss, Leah M. Zorrilla
Publikováno v:
Reproductive Toxicology. 31:184-193
Atrazine (2-chloro-4-ethylamino-6-isopropylamino-s-triazine) was introduced in the 1950s as a broad spectrum herbicide, and remains one of the most widely used herbicides in the United States. Several studies have suggested that atrazine modifies ste
Publikováno v:
Reproductive Toxicology. 29:393-400
Chlorotriazine herbicides, such as atrazine and its metabolites, have been shown to target the neuroendocrine regulation of male and female reproductive development. However, no studies have evaluated the effects of the chlorotriazine simazine on pub