Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Leah M. Hesse"'
Publikováno v:
Journal of Zoo and Wildlife Medicine. 39:590-595
Buprenorphine, a mu opioid receptor agonist, is expected to be a suitable analgesic drug for use in reptiles. However, to date, dosage recommendations have been based on anecdotal observations. The aim of this study was to provide baseline pharmacoki
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8670854bdd78df0a0cfabe8e5773bccb
https://doi.org/10.1638/2008-0033.1
https://doi.org/10.1638/2008-0033.1
Autor:
Leah M. Hesse, Mikko Koskinen, Päivi Toivonen, Moshe Finel, Sanna Kaivosaari, Michael H. Court
Publikováno v:
Molecular Pharmacology. 72:761-768
Nicotine biotransformation affects the smoking habits of addicted individuals and therefore their health risk. Using an improved analytical method, we have discovered that the human UDP-glucuronosyltransferase (UGT) 2B10, a liver enzyme previously un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::835c9815780ceb7d7e28352a92483b20
https://doi.org/10.1124/mol.107.037093
https://doi.org/10.1124/mol.107.037093
Publikováno v:
The Journal of Clinical Pharmacology. 46:567-576
A drug-drug interaction study was conducted to determine whether ritonavir (200 mg; 4 doses over 2 days) alters the pharmacokinetic disposition of bupropion (75 mg; once) coadministered to 7 healthy volunteers in a placebo-controlled 2-way crossover
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55bf56119a60f9cfe2e5fcf49dadac90
https://doi.org/10.1177/0091270006286981
https://doi.org/10.1177/0091270006286981
Autor:
Qin Hao, Michael H. Court, Soundararajan Krishnaswamy, Abdul Al-Rohaimi, Lisa L. von Moltke, David J. Greenblatt, Leah M. Hesse
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 313:1340-1346
The objective of this study was to use recombinant enzymes and human liver microsomes (HLMs) to comprehensively evaluate the functional impact of the three most common nonsynonymous polymorphisms (S7A, T181A, and R184S) identified in the human UDP gl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c80f2d7d124b09d666cefb312e37839
https://doi.org/10.1124/jpet.104.081968
https://doi.org/10.1124/jpet.104.081968
Autor:
Hermann R. Ochs, Ronenn Roubenoff, David J. Greenblatt, Jerold S. Harmatz, Leah M. Hesse, Lisa L. von Moltke, Richard I. Shader, Joel O. Olubodun
Publikováno v:
British Journal of Clinical Pharmacology. 56:297-304
Aims The influence of ageing on the pharmacokinetics of zolpidem, an extensively prescribed hypnotic medication, was evaluated in healthy human volunteers. Methods A series of 16 elderly (age: 61–85 years) and 24 young (age: 22–42 years) voluntee
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f8f5e442c0fab977d14a42e98e58826
https://doi.org/10.1046/j.0306-5251.2003.01852.x
https://doi.org/10.1046/j.0306-5251.2003.01852.x
Publikováno v:
CNS Drugs. 17:513-532
Insomnia, an inability to initiate or maintain sleep, affects approximately one-third of the American population. Conventional benzodiazepines, such as triazolam and midazolam, were the treatment of choice for short-term insomnia for many years but a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9483777920a556ed83f63c826918f60d
https://doi.org/10.2165/00023210-200317070-00004
https://doi.org/10.2165/00023210-200317070-00004
Autor:
Leah M. Hesse, Lisa L. von Moltke, Barbara F. Roth-Schechter, David J. Greenblatt, Michael D. Perloff, James L. Weemhoff, Jerold S. Harmatz
Publikováno v:
Biopharmaceutics & Drug Disposition. 23:361-367
The influence of high concentrations of zolpidem (100 microM, corresponding to approximately 200 times maximum therapeutic concentrations) on the activity of six human Cytochrome P450 (CYP) enzymes was evaluated in a model system using human liver mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a70604895c41d74b1a9aa155f0b749b
https://doi.org/10.1002/bdd.329
https://doi.org/10.1002/bdd.329
Publikováno v:
Anesthesiology. 94:110-119
Background Oxidation of propofol to 4-hydroxypropofol represents a significant pathway in the metabolism of this anesthetic agent in humans. The aim of this study was to identify the principal cytochrome P-450 (CYP) isoforms mediating this biotransfo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e337be04120563d7319351d5a1c3daa
https://doi.org/10.1097/00000542-200101000-00021
https://doi.org/10.1097/00000542-200101000-00021
Autor:
Gina Masse, Xi He, Suwagmani Hazarika, David J. Greenblatt, Jerold S. Harmatz, Michael H. Court, Leah M. Hesse
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT • UDP-glucuronosyltransferase (UGT) 2B15 is a major drug glucuronidation enzyme expressed in human liver. • Oxazepam is an isoform-selective probe drug that is being used for in vitro studies of UGT2B15.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9253110dfee6fa2396c75482a49a2bfe
https://europepmc.org/articles/PMC2791978/
https://europepmc.org/articles/PMC2791978/
Autor:
Michael H. Court, Leah M. Hesse, Soundararajan Krishnaswamy, David J. Greenblatt, Abdulmohsen Al-Rohaimi, Lisa L. von Moltke, Qin Hao
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 313(3)
UDP glucuronosyltransferase (UGT) 1A6 is a major isoform in human liver that glucuronidates numerous drugs, toxins, and endogenous substrates with high interindividual variability. The molecular basis for this variability remains unknown, although it
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d282323c9e91a44772b99dcdec5abd39
https://pubmed.ncbi.nlm.nih.gov/15761114
https://pubmed.ncbi.nlm.nih.gov/15761114