Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Leah M. Gayo-Fung"'
Autor:
Stephanie Lipps, Miguel S. Barbosa, Bernd Stein, May S Kung Sutherland, David W. Anderson, Nandita Patnaik, Weilin Xie, Sak Khammungkune, Helen Brady, Leah M. Gayo-Fung
Publikováno v:
Cytokine. 23:1-14
Bone metabolism requires tightly coupled activities exhibited by two unique cell populations, the bone-resorbing osteoclasts and the bone-forming osteoblasts. Imbalance in the function of these two cell types can result in osteoporosis, a condition c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::060bef1eb9f1438b4af0d4e506f15712
https://doi.org/10.1016/s1043-4666(03)00179-0
https://doi.org/10.1016/s1043-4666(03)00179-0
Autor:
Adam Kois, Bernd Stein, Graciella Shevlin, May S Kung Sutherland, Steve Pierce, Shripad S. Bhagwat, Stephanie Lipps, Helen Brady, Leah M. Gayo-Fung, Matt Hickman, Mary Doubleday, David W. Anderson, Normand Richard, Khammungkhune Sak
Publikováno v:
Molecular Pharmacology. 61:562-568
We determined the differential response of a novel SERM, SP500263, on estrogen receptor (ER) alpha and the more recently cloned ER-beta. Because of the high homology of amino acid residues in the ligand-binding domain of ER-alpha and ER-beta, we were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31dffcef6a200a5684a7214a17de7d53
https://doi.org/10.1124/mol.61.3.562
https://doi.org/10.1124/mol.61.3.562
Publikováno v:
Tetrahedron. 54:4141-4150
Ion-exchange resins are useful as scavengers in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to remove reaction byproducts. Acidic ion-exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b5296d5526ed2f16b61432ee528ae31
https://doi.org/10.1016/s0040-4020(98)00141-0
https://doi.org/10.1016/s0040-4020(98)00141-0
Publikováno v:
ChemInform. 29
Ion-exchange resins are useful as scavengers in solution-phase parallel synthesis. Ester and amide libraries have been generated using basic ion-exchange resins to facilitate the formation of products and to remove reaction byproducts. Acidic ion-exc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::46b0cb677b93ba8e599364b137487002
https://doi.org/10.1002/chin.199830079
https://doi.org/10.1002/chin.199830079
Autor:
Mark Sato, Paul Erdman, Leah M. Gayo-Fung, Cheryl Spooner, Graziella I. Shevlin, M. E. Goldman, Moorthy S. S. Palanki, Lynn J. Ransone
Publikováno v:
ChemInform. 34
Several analogues of ethyl 2-[(3-methyl-2,5-dioxo(3-pyrrolinyl))amino]-4-(trifluoromethyl)pyrimidine-5-carboxylate (1) were synthesized and tested as inhibitors of AP-1 and NF-kappaB mediated transcriptional activation in Jurkat T cells. From our SAR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5eaf6720b8db68ab7c16fd3e22d36916
https://doi.org/10.1002/chin.200302216
https://doi.org/10.1002/chin.200302216
Autor:
Helen, Brady, Sonal, Desai, Leah M, Gayo-Fung, Sak, Khammungkhune, Jeffrey A, McKie, Eoin, O'Leary, Laura, Pascasio, May Kung, Sutherland, David W, Anderson, Shripad S, Bhagwat, Bernd, Stein
Publikováno v:
Cancer research. 62(5)
We have compared the antitumor activities of SP500263, a novel next-generation selective estrogen receptor modulator (SERM), tamoxifen, and raloxifene side-by-side in in vitro and in vivo MCF-7 breast cancer models. In vitro, SP500263 acted as an ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e0d76f88cd99836d34f3a2a5787a02f4
https://pubmed.ncbi.nlm.nih.gov/11888917
https://pubmed.ncbi.nlm.nih.gov/11888917
Autor:
Lynn J. Ransone, Leah M. Gayo-Fung, Anthony M. Manning, Robert W. Sullivan, Brydon L. Bennett, Graziella I. Shevlin, Moorthy S. S. Palanki, M. E. Goldman, Mark J. Suto, Paul Erdman
Publikováno v:
Journal of medicinal chemistry. 43(21)
We investigated the structure-activity relationship studies of N-[3, 5-bis(trifluoromethyl)phenyl][2-chloro-4-(trifluoromethyl)pyrimidin-5 -yl]carboxamide (1), an inhibitor of transcription mediated by both NF-kappaB and AP-1 transcription factors, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4219662628e1c9dad52e06f4c924ef7e
https://pubmed.ncbi.nlm.nih.gov/11052805
https://pubmed.ncbi.nlm.nih.gov/11052805