Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Leah M Smith"'
Publikováno v:
Crispr. :145-162
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fe2863b363ca3071742db26d22bd90b
https://doi.org/10.1002/9781683673798.ch10
https://doi.org/10.1002/9781683673798.ch10
Publikováno v:
mSphere, Vol 4, Iss 1 (2019)
ABSTRACT Bacteria often live in complex communities in which they interact with other organisms. Consideration of the social environment of bacteria can reveal emergent traits and behaviors that would be overlooked by studying bacteria in isolation.
Externí odkaz:
https://doaj.org/article/cc37da4fae484755829f130998857ee0
Autor:
Marina Mahler, Lucia M. Malone, Daan F. van den Berg, Leah M. Smith, Stan J. J. Brouns, Peter C. Fineran
Publikováno v:
Microbial Genomics, 9(3)
Serratia sp. ATCC 39006 is a Gram-negative bacterium that has been used to study the function of phage defences, such as CRISPR–Cas, and phage counter-defence mechanisms. To expand our phage collection to study the phage–host interaction with Ser
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d693b43f16a0c24bf63b63397dc48571
https://doi.org/10.1099/mgen.0.000968
https://doi.org/10.1099/mgen.0.000968
Autor:
Hannah G. Hampton, Peter C. Fineran, Thorsten Bischler, Aroa Rey Campa, Simon A. Jackson, Cynthia M. Sharma, Leah M Smith, Sahil Sharma
Publikováno v:
Nucleic Acids Research
CRISPR–Cas systems provide bacteria with adaptive immunity against phages and plasmids; however, pathways regulating their activity are not well defined. We recently developed a high-throughput genome-wide method (SorTn-seq) and used this to uncove
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b66162a722089286c63ee582919fcd4
https://doi.org/10.1093/nar/gkab704
https://doi.org/10.1093/nar/gkab704
Publikováno v:
Nature Protocols. 16:4382-4418
We recently developed a high-throughput functional genomics approach, named 'SorTn-seq', to identify factors affecting expression of any gene of interest in bacteria. Our approach facilitates high-throughput screening of complex mutant pools, a task
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d7e752409d0dd10bb3e681df4891442
https://doi.org/10.1038/s41596-021-00582-6
https://doi.org/10.1038/s41596-021-00582-6
Autor:
Leah M. Smith, Peter C. Fineran
Publikováno v:
Molecular Cell. 83:165-166
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6538beecca08e566f6c8cad8d7f957ec
https://doi.org/10.1016/j.molcel.2022.12.020
https://doi.org/10.1016/j.molcel.2022.12.020
Autor:
David Mayo-Muñoz, Leah M. Smith, Carmela Garcia-Doval, Lucia M. Malone, Kate R. Harding, Simon A. Jackson, Hannah G. Hampton, Robert D. Fagerlund, Laura F. Gumy, Peter C. Fineran
Publikováno v:
Molecular cell. 82(23)
Bacteria have diverse defenses against phages. In response, jumbo phages evade multiple DNA-targeting defenses by protecting their DNA inside a nucleus-like structure. We previously demonstrated that RNA-targeting type III CRISPR-Cas systems provide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c98df0f42e20416c2589d3df0fdfb5b
https://pubmed.ncbi.nlm.nih.gov/36395770
https://pubmed.ncbi.nlm.nih.gov/36395770
Autor:
Will D. King, Anthony B. Miller, Stephen D. Walter, Chaohui Lu, Christine M. Friedenreich, Leah M. Smith, S. Memon, Abbey E Poirier, Karena D. Volesky, Keiko Asakawa, Joy Pader, Paul J. Villeneuve, Darren R. Brenner, Prithwish De, Yibing Ruan
Publikováno v:
Can J Public Health
Modifiable lifestyle, environmental, and infectious risk factors associated with cancer impact both cancer incidence and mortality at the population level. Most studies estimating this burden focus on cancer incidence. However, because these risk fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c255638d3084ebaa64fa1b9d1c4930bb
https://doi.org/10.17269/s41997-020-00455-7
https://doi.org/10.17269/s41997-020-00455-7
Autor:
Lucia M. Malone, James E. Ussher, Leah M Smith, Peter C. Fineran, Paul P. Gardner, Simon A. Jackson
Publikováno v:
Nature Microbiology. 6:162-172
Bacteria harbour multiple innate defences and adaptive CRISPR-Cas systems that provide immunity against bacteriophages and mobile genetic elements. Although some bacteria modulate defences in response to population density, stress and metabolic state
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdac363505f4588f65068d20f6abd11c
https://doi.org/10.1038/s41564-020-00822-7
https://doi.org/10.1038/s41564-020-00822-7
Autor:
Amanda Shaw, Leah M. Smith, Hannah K. Weir, Cheryl Louzado, Donna Turner, Larry F. Ellison, Alain A. Demers, Ryan Woods, Darren R. Brenner
Publikováno v:
Canadian Medical Association Journal. 192:E199-E205
BACKGROUND: Cancer projections to the current year help in policy development, planning of programs and allocation of resources. We sought to provide an overview of the expected incidence and mortality of cancer in Canada in 2020 in follow-up to the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa35a6f33b3bfabb6e291fd684a4bd8f
https://doi.org/10.1503/cmaj.191292
https://doi.org/10.1503/cmaj.191292