Secretion of Rhoptry and Dense Granule Effector Proteins by Nonreplicating Toxoplasma gondii Uracil Auxotrophs Controls the Development of Antitumor Immunity.

Autor: Barbara A Fox, Kiah L Sanders, Leah M Rommereim, Rebekah B Guevara, David J Bzik

Publikováno v: PLoS Genetics, Vol 12, Iss 7, p e1006189 (2016)

Nonreplicating type I uracil auxotrophic mutants of Toxoplasma gondii possess a potent ability to activate therapeutic immunity to established solid tumors by reversing immune suppression in the tumor microenvironment. Here we engineered targeted del

Externí odkaz: https://doaj.org/article/b8608f705a304a5a90e03c8867782cdd

Toxoplasma gondii rhoptry kinase ROP16 activates STAT3 and STAT6 resulting in cytokine inhibition and arginase-1-dependent growth control.

Autor: Barbara A Butcher, Barbara A Fox, Leah M Rommereim, Sung Guk Kim, Kirk J Maurer, Felix Yarovinsky, De'Broski R Herbert, David J Bzik, Eric Y Denkers

Publikováno v: PLoS Pathogens, Vol 7, Iss 9, p e1002236 (2011)

The ROP16 kinase of Toxoplasma gondii is injected into the host cell cytosol where it activates signal transducer and activator of transcription (STAT)-3 and STAT6. Here, we generated a ROP16 deletion mutant on a Type I parasite strain background, as

Externí odkaz: https://doaj.org/article/5d5a3e6ddba6441b90a69369ee02286d

A small sustained increase in NOD1 abundance promotes ligand-independent inflammatory and oncogene transcriptional responses

Autor: Ronald N. Germain, Ram Savan, Clifford Rostomily, Ajay Suresh Akhade, Naeha Subramanian, Carolyn Hutcheon, Iain D. C. Fraser, Nicolas W. Lounsbury, Bhaskar Dutta, Leah M. Rommereim

Publikováno v: Sci Signal

Small, genetically determined differences in transcription [expression quantitative trait loci (eQTLs)] are implicated in complex diseases through unknown molecular mechanisms. Here, we showed that a small, persistent increase in the abundance of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40234f74b9fea26804fd42bc8e0c58d6
https://doi.org/10.1126/scisignal.aba3244

Toxoplasma gondii Parasitophorous Vacuole Membrane-Associated Dense Granule Proteins Orchestrate Chronic Infection and GRA12 Underpins Resistance to Host Gamma Interferon

Autor: Marie-France Cesbron-Delauw, Valeria Bellini, Camille Rak, Barbara A. Fox, Graciane Petre, Leah M. Rommereim, David J. Bzik, Gregory A. Taylor, Alejandra Falla, Corinne Mercier, Rebekah B. Guevara, Jean-François Dubremetz, Viviana Cantillana

Publikováno v: mBio
mBio, 2019, 10 (4), ⟨10.1128/mBio.00589-19⟩
mBio, American Society for Microbiology, 2019, 10 (4), ⟨10.1128/mBio.00589-19⟩
mBio, Vol 10, Iss 4 (2019)
mBio, Vol 10, Iss 4, p e00589-19 (2019)

Toxoplasma gondii cysts reactivate during immune deficiency and cause fatal encephalitis. Parasite molecules that coordinate the development of acute and chronic infection are poorly characterized. Here, we show that many intravacuolar network membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb36a7cfe8c13cf4a2faa56216b6efe
http://europepmc.org/articles/PMC6606796

A sustained small increase in NOD1 expression promotes ligand-independent oncogenic activity

Autor: Iain D. C. Fraser, Carolyn Hutcheon, Nicolas W. Lounsbury, Naeha Subramanian, Ronald N. Germain, Bhaskar Dutta, Ram Savan, Clifford Rostomily, Leah M. Rommereim, Ajay Suresh Akhade

Small genetically-determined differences in transcription (eQTLs) are implicated in complex disease but the mechanisms by which small changes in gene expression impact complex disease are unknown. Here we show that a persistent small increase in expr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2db7c9b1203b69722995b4b6c8b7ad59
https://doi.org/10.1101/518886