Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Leah M Rommereim"'
Autor:
Leah M. Rommereim, Barbara A. Fox, Kiah L. Butler, Viviana Cantillana, Gregory A. Taylor, David J. Bzik
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Toxoplasma gondii secretes rhoptry (ROP) and dense granule (GRA) effector proteins to evade host immune clearance mediated by interferon gamma (IFN-γ), immunity-related GTPase (IRG) effectors, and CD8+ T cells. Here, we investigated the role of para
Externí odkaz:
https://doaj.org/article/abeff253034f400bb3a7de88edd65bcc
Autor:
Barbara A. Fox, Rebekah B. Guevara, Leah M. Rommereim, Alejandra Falla, Valeria Bellini, Graciane Pètre, Camille Rak, Viviana Cantillana, Jean-François Dubremetz, Marie-France Cesbron-Delauw, Gregory A. Taylor, Corinne Mercier, David J. Bzik
Publikováno v:
mBio, Vol 10, Iss 4 (2019)
ABSTRACT Toxoplasma gondii evades host immunity to establish a chronic infection. Here, we assessed the role of parasitophorous vacuole (PV) membrane (PVM)- and intravacuolar network (IVN) membrane-localized dense granule (GRA) proteins in the develo
Externí odkaz:
https://doaj.org/article/ef77c5b30b284e599b6b47cf0cdd3e64
Autor:
Jodie Lopez, Amina Bittame, Céline Massera, Virginie Vasseur, Grégory Effantin, Anne Valat, Célia Buaillon, Sophie Allart, Barbara A. Fox, Leah M. Rommereim, David J. Bzik, Guy Schoehn, Winfried Weissenhorn, Jean-François Dubremetz, Jean Gagnon, Corinne Mercier, Marie-France Cesbron-Delauw, Nicolas Blanchard
Publikováno v:
Cell Reports, Vol 13, Iss 10, Pp 2273-2286 (2015)
Apicomplexa parasites such as Toxoplasma gondii target effectors to and across the boundary of their parasitophorous vacuole (PV), resulting in host cell subversion and potential presentation by MHC class I molecules for CD8 T cell recognition. The h
Externí odkaz:
https://doaj.org/article/bed759afc9704f54bdc70e40d2319003
Autor:
Barbara A. Fox, Leah M. Rommereim, Rebekah B. Guevara, Alejandra Falla, Miryam Andrea Hortua Triana, Yanbo Sun, David J. Bzik
Publikováno v:
mBio, Vol 7, Iss 3 (2016)
ABSTRACT Ingestion of the obligate intracellular protozoan parasite Toxoplasma gondii causes an acute infection that leads to chronic infection of the host. To facilitate the acute phase of the infection, T. gondii manipulates the host response by se
Externí odkaz:
https://doaj.org/article/0ec0ff4f48d74421a21043f39df20e32
Publikováno v:
PLoS Genetics, Vol 12, Iss 7, p e1006189 (2016)
Nonreplicating type I uracil auxotrophic mutants of Toxoplasma gondii possess a potent ability to activate therapeutic immunity to established solid tumors by reversing immune suppression in the tumor microenvironment. Here we engineered targeted del
Externí odkaz:
https://doaj.org/article/b8608f705a304a5a90e03c8867782cdd
Autor:
Leah M Rommereim, Valeria Bellini, Barbara A Fox, Graciane Pètre, Camille Rak, Bastien Touquet, Delphine Aldebert, Jean-François Dubremetz, Marie-France Cesbron-Delauw, Corinne Mercier, David J Bzik
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159306 (2016)
Toxoplasma gondii actively invades host cells and establishes a parasitophorous vacuole (PV) that accumulates many proteins secreted by the dense granules (GRA proteins). To date, at least 23 GRA proteins have been reported, though the function(s) of
Externí odkaz:
https://doaj.org/article/50efb8f011c14294b5231bb87e8c5b4d
Autor:
Naeha Subramanian, Ronald N. Germain, Iain D. C. Fraser, Ajay Suresh Akhade, Leah M. Rommereim
Publikováno v:
Bio Protoc
The ability to identify the role of a particular gene within a system is dependent on control of the expression of that gene. In this protocol, we describe a method for stable, conditional expression of Nod-Like receptors (NLRs) in THP-1 cells using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d03578fe887a5be5738c5f6cb6e90950
https://doi.org/10.21769/bioprotoc.4205
https://doi.org/10.21769/bioprotoc.4205
Autor:
Ronald N. Germain, Ram Savan, Clifford Rostomily, Ajay Suresh Akhade, Naeha Subramanian, Carolyn Hutcheon, Iain D. C. Fraser, Nicolas W. Lounsbury, Bhaskar Dutta, Leah M. Rommereim
Publikováno v:
Sci Signal
Small, genetically determined differences in transcription [expression quantitative trait loci (eQTLs)] are implicated in complex diseases through unknown molecular mechanisms. Here, we showed that a small, persistent increase in the abundance of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40234f74b9fea26804fd42bc8e0c58d6
https://doi.org/10.1126/scisignal.aba3244
https://doi.org/10.1126/scisignal.aba3244
Autor:
Barbara A Butcher, Barbara A Fox, Leah M Rommereim, Sung Guk Kim, Kirk J Maurer, Felix Yarovinsky, De'Broski R Herbert, David J Bzik, Eric Y Denkers
Publikováno v:
PLoS Pathogens, Vol 7, Iss 9, p e1002236 (2011)
The ROP16 kinase of Toxoplasma gondii is injected into the host cell cytosol where it activates signal transducer and activator of transcription (STAT)-3 and STAT6. Here, we generated a ROP16 deletion mutant on a Type I parasite strain background, as
Externí odkaz:
https://doaj.org/article/5d5a3e6ddba6441b90a69369ee02286d
Autor:
Viviana Cantillana, Barbara A. Fox, Leah M. Rommereim, Kiah L. Butler, Gregory A. Taylor, David J. Bzik
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Toxoplasma gondii secretes rhoptry (ROP) and dense granule (GRA) effector proteins to evade host immune clearance mediated by interferon gamma (IFN-γ), immunity-related GTPase (IRG) effectors, and CD8+ T cells. Here, we investigated the role of para
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e77f1b2933218637e329b8ea3197a07
https://www.frontiersin.org/article/10.3389/fimmu.2019.02104/full
https://www.frontiersin.org/article/10.3389/fimmu.2019.02104/full