Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leah L, Lagpacan"'
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The mechanisms for this tumor specificity of platinum-based compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc12a447e6712d143b4af76723b2a50d
https://doi.org/10.1158/0008-5472.c.6494126
https://doi.org/10.1158/0008-5472.c.6494126
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Supplementary Table 1 from Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05465810f312ba00278db2bf1329f602
https://doi.org/10.1158/0008-5472.22364303
https://doi.org/10.1158/0008-5472.22364303
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Supplementary Figure 1 Legend from Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4a3e8891f1b0fb9f3fba1c921cf17f3e
https://doi.org/10.1158/0008-5472.22364309.v1
https://doi.org/10.1158/0008-5472.22364309.v1
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Supplementary Table 2 from Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bf618e3af97dbc29f3e182e4bd7b267
https://doi.org/10.1158/0008-5472.22364300.v1
https://doi.org/10.1158/0008-5472.22364300.v1
Supplementary Figure 1 from Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
Autor:
Kathleen M. Giacomini, Stephen J. Lippard, Xin Chen, Joe W. Gray, Takafumi Komori, Ying Chen, Anna Lapuk, Yan Shu, Leah L. Lagpacan, James E. Shima, Katherine S. Lovejoy, Shuzhong Zhang
Supplementary Figure 1 from Organic Cation Transporters Are Determinants of Oxaliplatin Cytotoxicity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e0a4a223fba0a4dfcf08d68b6faec9f
https://doi.org/10.1158/0008-5472.22364306
https://doi.org/10.1158/0008-5472.22364306
Autor:
Thomas J, Urban, Chen, Yang, Leah L, Lagpacan, Chaline, Brown, Richard A, Castro, Travis R, Taylor, Conrad C, Huang, Douglas, Stryke, Susan J, Johns, Michiko, Kawamoto, Elaine J, Carlson, Thomas E, Ferrin, Esteban G, Burchard, Kathleen M, Giacomini
Publikováno v:
Pharmacogenetics and Genomics. 17:773-782
OCTN1 is a multispecific transporter of organic cations and zwitterions, including several clinically important drugs as well as the antioxidant ergothioneine. OCTN1 is highly expressed in the kidney, where it is thought to aid in active secretion of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::669427edd0777d7a27cbc72a63f6739d
https://doi.org/10.1097/fpc.0b013e3281c6d08e.
https://doi.org/10.1097/fpc.0b013e3281c6d08e.
Autor:
Leah L. Lagpacan, Stephen J. Lippard, Takafumi Komori, Kathleen M. Giacomini, Yan Shu, Ying Chen, Xin Chen, Joe W. Gray, James E. Shima, Anna Lapuk, Katherine S. Lovejoy, Shuzhong Zhang
Publikováno v:
Cancer Research. 66:8847-8857
Although the platinum-based anticancer drugs cisplatin, carboplatin, and oxaliplatin have similar DNA-binding properties, only oxaliplatin is active against colorectal tumors. The mechanisms for this tumor specificity of platinum-based compounds are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2705e113ccba5f40f0cf3ca5ad2321f
https://doi.org/10.1158/0008-5472.can-06-0769
https://doi.org/10.1158/0008-5472.can-06-0769
Autor:
Melanie De La Cruz, Esteban G. Burchard, Leah L. Lagpacan, Kathleen M. Giacomini, Elaine J. Carlson, Douglas Stryke, Travis R. Taylor, Claire M. Brett, Conrad C. Huang, Thomas J. Urban, Thomas E. Ferrin, Lara M. Mangravite, Susan J. Johns, Michiko Kawamoto, Andrew R. Erdman, Richard A. Castro, Wendy Chan
Publikováno v:
American Journal of Physiology-Renal Physiology. 290:F905-F912
The human organic anion transporter, OAT3 ( SLC22A8), plays a critical role in renal drug elimination, by mediating the entry of a wide variety of organic anions, including a number of commonly used pharmaceuticals, into the renal proximal tubular ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9ce746a38b55d7cf3a0f5fe68b0bdab
https://doi.org/10.1152/ajprenal.00272.2005
https://doi.org/10.1152/ajprenal.00272.2005
Autor:
Kathleen M. Giacomini, Leah L. Lagpacan, Richard A. Castro, Claire M. Brett, Seymour Packman, Thomas J. Urban, Elaine J. Carlson, Renata C. Gallagher, Esteban G. Burchard, Chaline Brown, Travis R. Taylor, Thomas E. Ferrin
Publikováno v:
Molecular pharmacology. 70(5)
Systemic carnitine deficiency (SCD) is a rare autosomal recessive disease resulting from defects in the OCTN2 ( SLC22A5 ) gene, which encodes the high-affinity plasma membrane carnitine transporter. Although OCTN2 is fairly well studied in its relati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c42925ce69e4f29be5a7d93d5817020
https://pubmed.ncbi.nlm.nih.gov/16931768
https://pubmed.ncbi.nlm.nih.gov/16931768
Autor:
Travis R. Taylor, Wendy Chan, Michiko Kawamoto, Richard A. Castro, Susan J. Johns, Esteban G. Burchard, Tomoe Fujita, Doug Stryke, Elaine J. Carlson, Ira Herskowitz, Chaline Brown, Maya K. Leabman, Kathleen M. Giacomini, Leah L. Lagpacan, Cilaire M. Brett, Andrew R. Erdman, Yan Shu, Melanie De La Cruz, Thomas E. Ferrin, Conrad C. Huang, Deanna L. Kroetz, Thomas J. Urban
Publikováno v:
Pharmacological reviews. 58(1)
Category: genotype Project: Pharmacogenetics of Membrane Transporters [Table 1][1] provides HUGO Gene Nomenclature Committee (HGNC) symbols, PharmGKB submission URLs, submission dates, and release dates. [Table 2][2] provides HGNC symbols, HGNC names
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a763fec6d1c6b31c4279c9c395d5d64
https://pubmed.ncbi.nlm.nih.gov/16507878
https://pubmed.ncbi.nlm.nih.gov/16507878