Zobrazeno 1 - 10 of 68 pro vyhledávání: '"Leah J Cosgrove"'
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Akademický článek
Blood-based protein biomarker panel for the detection of colorectal cancer.
Autor: Kim Y C Fung, Bruce Tabor, Michael J Buckley, Ilka K Priebe, Leanne Purins, Celine Pompeia, Gemma V Brierley, Trevor Lockett, Peter Gibbs, Jeanne Tie, Paul McMurrick, James Moore, Andrew Ruszkiewicz, Edouard Nice, Timothy E Adams, Antony Burgess, Leah J Cosgrove
Publikováno v: PLoS ONE, Vol 10, Iss 3, p e0120425 (2015)
The majority of colorectal cancer (CRC) cases are preventable by early detection and removal of precancerous polyps. Even though CRC is the second most common internal cancer in Australia, only 30 per cent of the population considered to have risk fa
Externí odkaz: https://doaj.org/article/8827e2575b9f434da9dbe99123f2a2c8
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2
Persistence of DNA adducts, hypermutation and acquisition of cellular resistance to alkylating agents in glioblastoma
Autor: Leah J. Cosgrove, Kim Y. C. Fung, Michael Fay, Richard Head, Dayle Rundle-Thiele, Jennifer H. Martin
Publikováno v: Cancer Biology & Therapy. 18:917-926
Glioblastoma is a lethal form of brain tumour usually treated by surgical resection followed by radiotherapy and an alkylating chemotherapeutic agent. Key to the success of this multimodal approach is maintaining apoptotic sensitivity of tumour cells
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d39b97a48375413fc4c4ee10f97240d
https://doi.org/10.1080/15384047.2017.1385680
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3
Repurposing some older drugs that cross the blood-brain barrier and have potential anticancer activity to provide new treatment options for glioblastoma
Autor: Dayle Rundle-Thiele, Leah J. Cosgrove, Jennifer H. Martin, Richard Head
Publikováno v: British Journal of Clinical Pharmacology. 81:199-209
Glioblastoma is a brain neoplasm with limited 5-year survival rates. Developments of new treatment regimens that improve patient survival in patients with glioblastoma are needed. It is likely that a number of existing drugs used in other conditions
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1218f862eab095a4c88c7141eb5bda88
https://doi.org/10.1111/bcp.12785
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4
Delineation of the IGF-II C domain elements involved in binding and activation of the IR-A, IR-B and IGF-IR
Autor: Briony E. Forbes, Kathy H. Surinya, Ilka Priebe, Leah J. Cosgrove, Gemma V. Brierley, S.T. Henderson, John C. Wallace, D.E.A. Catcheside
Publikováno v: Growth Hormone & IGF Research. 25:20-27
Objective Human insulin-like growth factor-I and -II (IGF-I and -II) ligands share a high degree of sequence and structural homology. Despite their similarities, IGF-I and IGF-II exhibit differential receptor binding and activation characteristics. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86f58d0f85d8a509013822b4a06b55b2
https://doi.org/10.1016/j.ghir.2014.09.004
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6
Colorectal Carcinogenesis: A Cellular Response to Sustained Risk Environment
Autor: Michelle Zucker, Desmond B. Williams, Cheng Cheng Ooi, Kim Y. C. Fung, David L. Topping, Trevor Lockett, Leah J. Cosgrove
Publikováno v: International Journal of Molecular Sciences, Vol 14, Iss 7, Pp 13525-13541 (2013)
International Journal of Molecular Sciences
The current models for colorectal cancer (CRC) are essentially linear in nature with a sequential progression from adenoma through to carcinoma. However, these views of CRC development do not explain the full body of published knowledge and tend to d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98917ee41e46f513997bf19e46393ba8
http://www.mdpi.com/1422-0067/14/7/13525
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7
Biochemical Characterization of Individual Human Glycosylated pro-Insulin-like Growth Factor (IGF)-II and big-IGF-II Isoforms Associated with Cancer
Autor: Lesley A. Pearce, Xiaowen Xiao, Sameer A. Greenall, Nicola A. Bartone, Lindsay G. Sparrow, Leah J. Cosgrove, John D. Bentley, Robert C. Baxter, Timothy E. Adams, Judith A. Scoble
Publikováno v: Journal of Biological Chemistry. 288:59-68
Insulin-like growth factor II (IGF-II) is a major embryonic growth factor belonging to the insulin-like growth factor family, which includes insulin and IGF-I. Its expression in humans is tightly controlled by maternal imprinting, a genetic restraint
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb2553b356f82071086be18f87a3982
https://doi.org/10.1074/jbc.m112.432013
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8
Valproate in adjuvant glioblastoma treatment
Autor: Peter Sminia, Stephen E. Rose, Richard Head, Leah J. Cosgrove, Nicholas Dowson, Jenny H Martin, Michael Fay
Publikováno v: Fay, M F, Head, R, Sminia, P, Dowson, N, Cosgrove, L, Rose, S E & Martin, J H 2016, ' Valproate in Adjuvant Glioblastoma Treatment ', Journal of Clinical Oncology, vol. 34, no. 25, pp. 3105-7 . https://doi.org/10.1200/JCO.2016.67.2162
Journal of Clinical Oncology, 34(25), 3105-7. American Society of Clinical Oncology
Refereed/Peer-reviewed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1c504970376c84d2d53d0482e973425
https://hdl.handle.net/11541.2/123466
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9
Is the tissue persistence of O6-methyl-2′-deoxyguanosine an indicator of tumour formation in the gastrointestinal tract?
Autor: Richard Head, Trevor Lockett, Leah J. Cosgrove, Desmond B. Williams, Jacobus P. Gerber, Julie M. Clarke, Shir Ley Tan
Publikováno v: Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 721:119-126
Azoxymethane (AOM) is a methylating agent capable of inducing mutations in DNA by forming adducts with DNA bases. It has been used to understand the mechanisms involved in colon carcinogenesis. Of the adducts formed in response to AOM, O6-methyl-2'-d
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::698e6e26b430c8e7ca33179afb3f1fe0
https://doi.org/10.1016/j.mrgentox.2010.12.016
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10
Butyrate-Induced Apoptosis in HCT116 Colorectal Cancer Cells Includes Induction of a Cell Stress Response
Autor: Kim Y. C. Fung, Shaun R. McColl, Leah J. Cosgrove, Peter Hoffmann, Richard Head, Steve Henderson, Gemma V. Brierley, Trevor Lockett
Publikováno v: Journal of Proteome Research. 10:1860-1869
Short chain fatty acids (SCFA), principally butyrate, propionate, and acetate, are produced in the gut through the fermentation of dietary fiber by the colonic microbiotica. Butyrate in particular is the preferred energy source for the cells in the c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::978bf0e8211391e8d7a86ab5b9aae44e
https://doi.org/10.1021/pr1011125
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