Výsledky vyhledávání - "Leah Gillespie"

A Putative Lipid-Associating Motif in the West Nile Virus NS4A Protein Is Required for Efficient Virus Replication

Autor: Jason M. Mackenzie, Susann Liebscher, Leah Gillespie, Rebecca L Ambrose, Turgut E. Aktepe, Alice M Trenerry, Andrea Mikulasova

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Frontiers in Cell and Developmental Biology

Flavivirus replication is intimately associated with re-organized cellular membranes. These virus-induced changes in membrane architecture form three distinct membranous “organelles” that have specific functions during the flavivirus life cycle.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f9d6591f32c9b4ce366eb939ae26e4
https://doi.org/10.3389/fcell.2021.655606

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Saturation of influenza virus neutralization and antibody consumption can both lead to bistable growth kinetics

Autor: Vijaykrishna Dhanasekaran, Xiaoyun Yang, Tonghua Zhang, Stephen J. Turner, Shilian Xu, Leah Gillespie, Ada W. C. Yan, Moshe Olshansky, Heidi Peck, Ian G. Barr, Celeste M. Donato

Influenza virus is a major human health threat. Neutralizing antibodies elicited through prior infection or vaccination play an irreplaceable role in protection from subsequent infection. The efficacy of antibody-dependent vaccines relies on both vir

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Annual report on influenza viruses received and tested by the Melbourne WHO Collaborating Centre for Reference and Research on Influenza in 2016

Autor: Vivian.k Leung, Yi-Mo Deng, Matthew Kaye, Iwona Buettner, Hilda Lau, Sook-Kwan Leang, Leah Gillespie, Michelle.K Chow

Publikováno v: Communicable diseases intelligence (2018). 43

As part of its role in the World Health Organization’s (WHO) Global Influenza Surveillance and Response System (GISRS), the WHO Collaborating Centre for Reference and Research on Influenza in Melbourne received a total of 4,247 human influenza posi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78828adc1824abe876a7079e72bae15e
https://pubmed.ncbi.nlm.nih.gov/30739429

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DC-SIGN and L-SIGN Are Attachment Factors That Promote Infection of Target Cells by Human Metapneumovirus in the Presence or Absence of Cellular Glycosaminoglycans

Autor: Andrew G. Brooks, Sarah L. Londrigan, Matthew S. Parsons, Rubaiyea Farrukee, Mark Krabbe, Kirsten Spann, Kathleen Gerstenberg, Leah Gillespie, Patrick C. Reading, Fernanda Ana-Sosa-Batiz

Publikováno v: Journal of Virology

It is well established that glycosaminoglycans (GAGs) function as attachment factors for human metapneumovirus (HMPV), concentrating virions at the cell surface to promote interaction with other receptors for virus entry and infection. There is incre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ddf62c45d3c4df9789869217daa9f4
https://doi.org/10.1128/jvi.00537-16

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Infection of Mouse Macrophages by Seasonal Influenza Viruses Can Be Restricted at the Level of Virus Entry and at a Late Stage in the Virus Life Cycle

Autor: Patrick C. Reading, Sarah L. Londrigan, Leah Gillespie, Kirsty R. Short, Joel Ma, Steven Rockman, Andrew G. Brooks

Publikováno v: Journal of Virology. 89:12319-12329

Airway epithelial cells are susceptible to infection with seasonal influenza A viruses (IAV), resulting in productive virus replication and release. Macrophages (MΦ) are also permissive to IAV infection; however, virus replication is abortive. Curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c07bccbd73970a516f556a5e21edf2
https://doi.org/10.1128/jvi.01455-15

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The first external quality assessment of isolation and identification of influenza viruses in cell culture in the Asia Pacific region, 2016

Autor: Iwona Buettner, Robert Shaw, Natalie Spirason, Yi-Mo Deng, Aparna Singh Shah, Leah Gillespie, Angela Todd, Frank Konings, Ian G. Barr, Patrick C. Reading, Vivian K.Y. Leung

Publikováno v: Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology. 97

Background The isolation and propagation of influenza viruses from clinical specimens are essential tools for comprehensive virologic surveillance. Influenza viruses must be amplified in cell culture for detailed antigenic analysis and for phenotypic

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https://pubmed.ncbi.nlm.nih.gov/29127947

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The West Nile virus assembly process evades the conserved antiviral mechanism of the interferon-induced MxA protein

Autor: Leah Gillespie, Antje Hoenen, Jason M. Mackenzie, Alexander A. Khromykh, Peter van der Heide, Garry Morgan

Publikováno v: Virology. 448:104-116

Flaviviruses have evolved means to evade host innate immune responses. Recent evidence suggests this is due to prevention of interferon production and signaling in flavivirus-infected cells. Here we show that the interferon-induced MxA protein can se

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Endocytic function is critical for influenza A virus infection via DC-SIGN and L-SIGN

Autor: Wy Ching Ng, Patrick C. Reading, Sarah L. Londrigan, Andrew G. Brooks, Leah Gillespie, Paula Roosendahl

Publikováno v: Scientific Reports

The ubiquitous presence of cell-surface sialic acid (SIA) has complicated efforts to identify specific transmembrane glycoproteins that function as bone fide entry receptors for influenza A virus (IAV) infection. The C-type lectin receptors (CLRs) DC

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