The genetic basis of aneuploidy tolerance in wild yeast

Autor: James Hose, Leah E Escalante, Katie J Clowers, H Auguste Dutcher, DeElegant Robinson, Venera Bouriakov, Joshua J Coon, Evgenia Shishkova, Audrey P Gasch

Publikováno v: eLife, Vol 9 (2020)

Aneuploidy is highly detrimental during development yet common in cancers and pathogenic fungi – what gives rise to differences in aneuploidy tolerance remains unclear. We previously showed that wild isolates of Saccharomyces cerevisiae tolerate ch

Externí odkaz: https://doaj.org/article/015b68d9383a453c8abee8df8945d841

The role of stress-activated RNA–protein granules in surviving adversity

Autor: Audrey P. Gasch, Leah E. Escalante

Publikováno v: RNA

Severe environmental stress can trigger a plethora of physiological changes and, in the process, significant cytoplasmic reorganization. Stress-activated RNA–protein granules have been implicated in this cellular overhaul by sequestering preexistin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b18bb17d10ae09709edf82dc90acec57
https://doi.org/10.1261/rna.078738.121

Author response: The genetic basis of aneuploidy tolerance in wild yeast

Autor: Joshua J. Coon, Leah E. Escalante, Venera Bouriakov, James Hose, Audrey P. Gasch, DeElegant Robinson, Evgenia Shishkova, H Auguste Dutcher, Katie J. Clowers

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f9a0c09a8957661ebeed63ed7744698a
https://doi.org/10.7554/elife.52063.sa2

Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress

Autor: Rhonda Bacher, Doina Ciobanu, Igor V. Grigoriev, Leah E. Escalante, Feiqiao Brian Yu, Megan N. McClean, James Hose, Christina Kendziorski, Michael Place, Laura Sandor, Stephen R. Quake, Jad Kanbar, Audrey P. Gasch

Publikováno v: PLoS Biology
PLoS Biology, Vol 15, Iss 12, p e2004050 (2017)
PLoS biology, vol 15, iss 12
Gasch, AP; Yu, FB; Hose, J; Escalante, LE; Place, M; Bacher, R; et al.(2017). Single-cell RNA sequencing reveals intrinsic and extrinsic regulatory heterogeneity in yeast responding to stress. PLoS Biology, 15(12). doi: 10.1371/journal.pbio.2004050. Lawrence Berkeley National Laboratory: Retrieved from: http://www.escholarship.org/uc/item/9hd480k9

From bacteria to humans, individual cells within isogenic populations can show significant variation in stress tolerance, but the nature of this heterogeneity is not clear. To investigate this, we used single-cell RNA sequencing to quantify transcrip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fa6beeb1af3701b10fcd976f14fb469
http://europepmc.org/articles/PMC5746276

Decoupling genetics, lineages, and microenvironment in IDH-mutant gliomas by single-cell RNA-seq

Autor: McKenzie Shaw, Christopher Mount, Miguel Rivera, Priscilla K. Brastianos, William T. Curry, Todd R. Golub, Matthew P. Frosch, Christina C. Luo, Ravindra Mylvaganam, Orit Rozenblatt-Rosen, Daniel P. Cahill, Danielle Dionne, Volker Hovestadt, Shawn M. Gillespie, Keren Yizhak, Hiroaki Wakimoto, Maristela L. Onozato, Christopher Rodman, Anoop P. Patel, Andrew S. Venteicher, Bradley E. Bernstein, Gad Getz, Mariella G. Filbin, Brian V. Nahed, Christine Hebert, Michelle Monje, A. John Iafrate, David N. Louis, Itay Tirosh, Cyril Neftel, Aviv Regev, Mario L. Suvà, Hiranmayi Ravichandran, Leah E. Escalante

Publikováno v: Science, vol. 355, no. 6332, pp. 1391
PMC

Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME).We dissected these influences in isocitrate dehydrogenase (IDH)-mutant gliomas by combining 14,226 sin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d7d666055f7b5926de64370899646af
https://serval.unil.ch/resource/serval:BIB_0420876AC9F2.P002/REF.pdf