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of 9
pro vyhledávání: '"Leah Dziopa"'
Autor:
Zheng Yang, Jenny Zilberberg, Eugenia Dziopa, Christopher J. Kirk, Robert Korngold, Shahin Assefnia, Leah Dziopa, Jennifer Matos
Publikováno v:
Biology of Blood and Marrow Transplantation. 21:1555-1564
In the current study we evaluated the effects of immunoproteasome inhibition using ONX 0914 (formerly PR-957) to ameliorate graft-versus-host disease (GVHD). ONX 0914, an LMP7-selective epoxyketone inhibitor of the immunoproteasome, has been shown to
Autor:
Sayeed Sameera, Leah Dziopa, Vega Beatriz, Michael C. Kiel, Adebobola Imeh-Nathaniel, Adam Brager, Thomas I. Nathaniel, Dana Baier
Publikováno v:
Brain Research Bulletin. 85:385-395
With a highly organized stereotypic behavior and a simplified neuronal system that is characterized by cellular modularity, crayfish (Orconectes rusticus) represents an excellent model that we used in this study to explore how a drug-conditioned-cue
Publikováno v:
Bone Research
Osteocytes reside as three-dimensionally (3D) networked cells in the lacunocanalicular structure of bones and regulate bone and mineral homeostasis. Despite of their important regulatory roles, in vitro studies of osteocytes have been challenging bec
Autor:
Saba Choudhary, Leah Dziopa, Lucas Tricoli, Maia Iyer, Eugenia Dziopa, Shain Assefnia, Christopher Albanese, Qiaoling Sun, Woo Y. Lee, Jenny Zilberberg
Publikováno v:
Cancer Research. 77:LB-145
Introduction: Prostate cancer (PCa) is the second leading cause of cancer related death in men in the US and remains incurable in the metastatic stage. Recent reports have shown that the adhesion molecule N-cadherin, a mesenchymal cadherin associated
Autor:
Iriana Colorado, Keyi Wang, Zheng Yang, Leah Dziopa, Eugenia Dziopa, Robert Korngold, Rena Feinman
Publikováno v:
Blood. 126:1865-1865
The failure to control both innate and adaptive immune responses in the gut has recently been implicated as a major pathogenic mechanism in the development of graft-versus-host disease (GVHD). Reduced oxygen availability in the intestine has been cau
Autor:
Iriana Colorado, Rena Feinman, Leah Dziopa, Anita Sreedhar, Jenny Zilberberg, Zheng Yang, Eugenia Dziopa, Robert Korngold
Publikováno v:
Blood. 124:539-539
Acute graft-versus-host disease (GVHD) is a major cause of nonrelapse morbidity and mortality following allogeneic blood and marrow transplantation (BMT). The majority of studies delineating the mechanisms involved in GVHD have focused on the allorea
Publikováno v:
Blood. 122:3258-3258
Introduction During graft-versus-host disease (GVHD), activated alloreactive T cells recirculate from the secondary lymphoid organs and extravasate via the blood vessels into target tissues, causing pathology which if severe enough can ultimately lea
Autor:
Moshe Z Miller, Rena Feinman, Thobekile T Ndlovu, Eugenia Dziopa, Robert Korngold, Iriana Colorado, Leah Dziopa, Jenny Zilberberg
Publikováno v:
Blood. 122:2006-2006
The intestinal epithelium is a primary target of graft-versus-host disease (GVHD). The hypoxia-signaling pathway has been implicated as an adaptive response in the intestinal epithelium in numerous models of inflammatory bowel disease, such as coliti
Autor:
Jennifer Matos, Zheng Yang, Eugenia Dziopa, Leah Dziopa, Christopher J. Kirk, Robert Korngold, Jenny Zilberberg
Publikováno v:
Blood. 122:4472-4472
Background Proteasome inhibition has been studied and used as a therapeutic target in the treatment of autoimmune disorders and multiple myeloma. Immune system cells, especially antigen-presenting cells, express a higher basal level of immunoproteaso