Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Leah Daly"'
Publikováno v:
Frontiers in Medicine, Vol 10 (2023)
BackgroundElderly people are known to be vulnerable to virus infection. However, this has not been appropriately tested in in vitro studies due to a lack of appropriate virus infection models. In this report, we investigated the impact of age on resp
Externí odkaz:
https://doaj.org/article/e9b45cec45044780a4562acee44c7f37
Autor:
Matthew Coates, Alison Murray, Kathy Woodward, Vicky Wheeler, Meabh McCurdy, Lindsey Cass, Kazuhiro Ito, Bryan Murray, Amanda Davis, Julie Mori, Elizabeth A. Meals, Garth Rapeport, Charlie Brindley, John P. DeVincenzo, Pete Strong, Leah Daly
Publikováno v:
The Journal of Infectious Diseases. 225:2087-2096
Background PC786 is a nebulized nonnucleoside respiratory syncytial virus (RSV) polymerase inhibitor designed to treat RSV, which replicates in the superficial layer of epithelial cells lining the airways. Methods Fifty-six healthy volunteers inocula
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6525cc6578189ec94d7fed43e5587f
https://doi.org/10.1093/infdis/jiaa716
https://doi.org/10.1093/infdis/jiaa716
Autor:
Thomas Colley, Pete Strong, Genki Kimura, Yuki Nishimoto, Yasuo Kizawa, Leah Daly, Gurpreet Sehra, Garth Rapeport, Kazuhiro Ito, Takahiro Nakaoki
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)
Scientific Reports
Scientific Reports
Invasive pulmonary Aspergillosis is a leading cause of morbidity and mortality in immunosuppressed patients and treatment outcomes using oral antifungal triazoles remain suboptimal. Here we show that combining topical treatment using PC945, a novel i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14a322f3d23c8befc314f0f01255a512
http://link.springer.com/article/10.1038/s41598-019-45890-w
http://link.springer.com/article/10.1038/s41598-019-45890-w
Autor:
Garth Rapeport, Jacques F. Meis, Yuki Nishimoto, Thomas Colley, Alexandre Alanio, Stéphane Bretagne, Kazuhiro Ito, Pete Strong, Anuradha Chowdhary, Genki Kimura, Leah Daly, Yasuo Kizawa, Cheshta Sharma, Takahiro Nakaoki
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives The growing emergence of azole-resistant Aspergillus fumigatus strains worldwide is a major concern for current systemic antifungal treatment. Here we report antifungal activities of a novel inhaled triazole, PC1244, against a collection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96b3282e4fc5c706fe37474d652d4c54
http://europepmc.org/articles/PMC6753496
http://europepmc.org/articles/PMC6753496
Autor:
Kazuhiro Ito, Kirstie Anya Lucas, Genki Kimura, Yuki Nishimoto, Yasuo Kizawa, Leah Daly, Pete Strong
Publikováno v:
Journal of Experimental Pathology. 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ca5362e90c3cb4a6bf5abea76c8234f4
https://doi.org/10.33696/pathology.2.011
https://doi.org/10.33696/pathology.2.011
Autor:
Kazuhiro, Ito, Yasuo, Kizawa, Genki, Kimura, Yuki, Nishimoto, Leah, Daly, Ian, Knowles, Mark, Hows, John, Ayrton, Pete, Strong
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 163
PC945 is a novel antifungal agent, optimised for inhaled treatment. In this study, the relationship between antifungal effects of PC945 and its exposure in the lungs was investigated in Aspergillus fumigatus intranasally infected, temporarily neutrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a253171a4c841a18ad8cdcad73747429
https://pubmed.ncbi.nlm.nih.gov/34015430
https://pubmed.ncbi.nlm.nih.gov/34015430
Autor:
Genki Kimura, Nishimoto Yuki, Leah Daly, Kazuhiro Ito, Kirstie Anya Lucas, Pete Strong, Kizawa Yasuo
Although Candida spp. are frequently detected in fungal cultures of respiratory secretions, their presence is normally assumed to reflect benign colonization. However, there is growing evidence that Candida spp. are involved in the pathogenesis of re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba5d56c9908ef32c91b1856ddb79b483
https://doi.org/10.1101/2020.07.27.222661
https://doi.org/10.1101/2020.07.27.222661
Autor:
Spyridon Papiris, Leah Daly, Andrianna I Papaioannou, Stelios Loukides, Petros Bakakos, Georgios Hillas, Anastasia Papaporfyriou, Kazuhiro Ito, Jonathan R. Baker, Evgenia Papathanasiou, Zoe Tsilogianni, Nikolaos Koulouris
Publikováno v:
Journal of Clinical Medicine
Volume 9
Issue 2
Journal of Clinical Medicine, Vol 9, Iss 2, p 473 (2020)
Volume 9
Issue 2
Journal of Clinical Medicine, Vol 9, Iss 2, p 473 (2020)
Background: Sestrin 2, Endocan, and Sirtuin 1 are distinct molecules with some biologic actions associated with asthma pathophysiology. The aim of the present study was to determine the molecular level differences attributable to underlying asthma se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d806f09ec97bac88cc0d006164b0ae49
https://pubmed.ncbi.nlm.nih.gov/32050426
https://pubmed.ncbi.nlm.nih.gov/32050426
Autor:
Samuel Constant, Mark Hows, Garth Rapeport, Kazuhiro Ito, Lindsey Cass, Leah Daly, Song Huang, Amanda Davis, Daniel W. Brookes, Pete Strong, Ian D Knowles, John Ayrton, Matthew Coates, Heather Allen
Publikováno v:
British Journal of Pharmacology. 175:2520-2534
Background and purpose Effective anti-respiratory syncytial virus (RSV) agents are still not available for clinical use. Current major targets are virus surface proteins, such as a fusion protein involved in viral entry, but agents effective after RS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5249d1be051e207dbc7e6f5ffbf5a2b0
https://doi.org/10.1111/bph.14221
https://doi.org/10.1111/bph.14221
Autor:
Leah Daly, Pete Strong, Yuki Nishimoto, Mark Hows, Yasuo Kizawa, Ian D Knowles, Kazuhiro Ito, Genki Kimura, John Ayrton
Publikováno v:
European Journal of Pharmaceutical Sciences. 163:105878
PC945 is a novel antifungal agent, optimised for inhaled treatment. In this study, the relationship between antifungal effects of PC945 and its exposure in the lungs was investigated in Aspergillus fumigatus intranasally infected, temporarily neutrop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b01bb50fdc17ff1dfabf136bb40d4ec
https://doi.org/10.1016/j.ejps.2021.105878
https://doi.org/10.1016/j.ejps.2021.105878