Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature.

Autor: Leah Cushing, Stefan Costinean, Wei Xu, Zhihua Jiang, Lindsey Madden, Pingping Kuang, Jingshu Huang, Alexandra Weisman, Akiko Hata, Carlo M Croce, Jining Lü

Publikováno v: PLoS Genetics, Vol 11, Iss 5, p e1005238 (2015)

Differentiation of lung vascular smooth muscle cells (vSMCs) is tightly regulated during development or in response to challenges in a vessel specific manner. Aberrant vSMCs specifically associated with distal pulmonary arteries have been implicated

Externí odkaz: https://doaj.org/article/ede5a6dd29574582a4728fb997aa02a2

The Roles of MicroRNAs and Protein Components of the MicroRNA Pathway in Lung Development and Diseases

Autor: Zhihua Jiang, Leah Cushing, Ping-Ping Kuang, Jining Lu

Publikováno v: American Journal of Respiratory Cell and Molecular Biology. 52:397-408

Decades of studies have shown evolutionarily conserved molecular networks consisting of transcriptional factors, diffusing growth factors, and signaling pathways that regulate proper lung development. Recently, microRNAs (miRNAs), small, noncoding re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f3ae976b496ee62fe096850fda603d3
https://doi.org/10.1165/rcmb.2014-0232rt

IRAK4 kinase activity controls Toll-like receptor–induced inflammation through the transcription factor IRF5 in primary human monocytes

Autor: Aaron Winkler, Katherine L. Lee, Wouter Korver, Rachael Hawtin, Lih-Ling Lin, Margaret Fleming, Vikram R. Rao, Scott A. Jelinsky, Leah Cushing

Interleukin-1 receptor–associated kinase 4 (IRAK4) plays a critical role in innate immune signaling by Toll-like receptors (TLRs), and loss of IRAK4 activity in mice and humans increases susceptibility to bacterial infections and causes defects in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ee786653c024ba05a487d084b0ba283
https://europepmc.org/articles/PMC5682975/

Interleukin 1/Toll-like Receptor-induced Autophosphorylation Activates Interleukin 1 Receptor-associated Kinase 4 and Controls Cytokine Induction in a Cell Type-specific Manner

Autor: Margaret Hirschfield, Ken Dower, Vikram R. Rao, Capucine Picard, Jean-Laurent Casanova, Marshall M. Siegel, Anne Puel, Robert M. Czerwinski, Leah Cushing, Quentin G. Wright, Wayne Stochaj, Lih-Ling Lin

Publikováno v: Journal of Biological Chemistry. 289:10865-10875

IRAK4 is a central kinase in innate immunity, but the role of its kinase activity is controversial. The mechanism of activation for IRAK4 is currently unknown, and little is known about the role of IRAK4 kinase in cytokine production, particularly in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b07f0b375f92067f483c6dae8009fc78
https://doi.org/10.1074/jbc.m113.544809

Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature

Autor: Alexandra S. Weisman, Jingshu Huang, Jining Lu, Wei Xu, Stefan Costinean, Lindsey H. Madden, Zhihua Jiang, Leah Cushing, Ping-Ping Kuang, Carlo M. Croce, Akiko Hata

Publikováno v: Cushing, L; Costinean, S; Xu, W; Jiang, Z; Madden, L; Kuang, P; et al.(2015). Disruption of miR-29 Leads to Aberrant Differentiation of Smooth Muscle Cells Selectively Associated with Distal Lung Vasculature. PLoS Genetics, 11(5). doi: 10.1371/journal.pgen.1005238. UCSF: Retrieved from: http://www.escholarship.org/uc/item/6ff4w71x
PLoS Genetics, Vol 11, Iss 5, p e1005238 (2015)
PLoS genetics, vol 11, iss 5
PLoS Genetics

Differentiation of lung vascular smooth muscle cells (vSMCs) is tightly regulated during development or in response to challenges in a vessel specific manner. Aberrant vSMCs specifically associated with distal pulmonary arteries have been implicated

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361327a073efc999605199dfc56f9e0b
http://www.escholarship.org/uc/item/6ff4w71x