Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Leah C. Wehmas"'
Autor:
Aero Renyer, Krishna Ravindra, Barbara A. Wetmore, Jermaine L. Ford, Michael DeVito, Michael F. Hughes, Leah C. Wehmas, Denise K. MacMillan
Publikováno v:
Toxics, Vol 11, Iss 12, p 951 (2023)
Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicoki
Externí odkaz:
https://doaj.org/article/f755faf0b693462dbddd645d9ae1fec7
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Formalin fixation of biological specimens damages nucleic acids and limits their use in genomic analyses. Previously, we showed that RNA isolation with an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of f
Externí odkaz:
https://doaj.org/article/c82f8591c92b4bb0a366519a2cd4a31f
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 883-894 (2022)
Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples wi
Externí odkaz:
https://doaj.org/article/abd933fa85be4600a08e1d6386fa3df4
Autor:
Justin M. Conley, Christy S. Lambright, Nicola Evans, Elizabeth Medlock-Kakaley, Donna Hill, James McCord, Mark J. Strynar, Leah C. Wehmas, Susan Hester, Denise K. MacMillan, L. Earl Gray, Jr.
Publikováno v:
Environment International, Vol 160, Iss , Pp 107056- (2022)
Nafion byproduct 2 (NBP2) is a polyfluoroalkyl ether sulfonic acid that was recently detected in surface water, drinking water, and human serum samples from monitoring studies in North Carolina, USA. We orally exposed pregnant Sprague-Dawley rats to
Externí odkaz:
https://doaj.org/article/a02a3d000c884df0b141b0a9e57a0cf2
Autor:
Leah C. Wehmas, Catherine Anders, Jordan Chess, Alex Punnoose, Cliff B. Pereira, Juliet A. Greenwood, Robert L. Tanguay
Publikováno v:
Toxicology Reports, Vol 2, Iss C, Pp 702-715 (2015)
Engineered metal oxide nanoparticles (MO NPs) are finding increasing utility in the medical field as anticancer agents. Before validation of in vivo anticancer efficacy can occur, a better understanding of whole-animal toxicity is required. We compar
Externí odkaz:
https://doaj.org/article/452e707c4092461c921d4c3a4dbe1c4a
Publikováno v:
Toxicology reports. 9
Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples wi
Publikováno v:
Scientific reports. 12(1)
Formalin fixation of biological specimens damages nucleic acids and limits their use in genomic analyses. Previously, we showed that RNA isolation with an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of formalin-i
Autor:
Anderson V. dePaula, Maria Cassia Mendes-Correa, Viviane A. Parisi, Camila Malta Romano, Emily A. Bruce, Clement Meseko, Thiago José Dionísio, Marielton dos Passos Cunha, Ismaila Shittu, Bernard Mari, Syril D Pettit, Bitrus Inuwa, Susan D. Hester, Rebekah E. Dumm, Keith R. Jerome, Ana Paula Pessoa Vilela, Jessica W. Crothers, Carlos Ferreira dos Santos, Ollivier Hyrien, O. O. Oladipo, Rebecca M. Harris, Leah C. Wehmas, Roger Chammas, Margaret G. Mills, Meei-Li Huang, A. C. A. Campos, Adamson S Muula, Pascal Barby, Luiz Gustavo Bentim Góes, Arianne Brown, Rajhab S. Mkakosya, Julien Fassy, Lemar Blake, Jose R W Martínez, Jason Botten, Cecilia Vial, Constance A Mitchell, Tonney S. Nyirenda, Christopher A. L. Oura, Paola Minoprio, Pablo Vial, Caroline Lacoux, Thais Francini Garbieri
Publikováno v:
medRxiv
Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) is used worldwide to test and trace the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). "Extraction-less" or "direct" real time-reverse transcription polym
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84149ab22e0a4d54b6fbd5346a712c74
https://doi.org/10.1101/2021.04.10.21254091
https://doi.org/10.1101/2021.04.10.21254091
Autor:
Leah C. Wehmas, Charles E. Wood, Gail M. Nelson, Susan D. Hester, Carole L. Yauk, Brian N. Chorley
Publikováno v:
Toxicol Sci
Formalin-fixed paraffin-embedded (FFPE) tissues provide an important resource for toxicogenomic research. However, variability in the integrity or quality of RNA obtained from archival FFPE specimens can lead to unreliable data and wasted resources,
Autor:
Adam Swank, Emily Wheaton, Charles E. Wood, Tamara Tal, Leah C. Wehmas, Tara R. Catron, Drake Phelps, James McCord, Jon R. Sobus, Nichole E. Brinkman, Mark J. Strynar, Randolph R. Singh, Scott P. Keely
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Estrogenic chemicals are widespread environmental contaminants associated with diverse health and ecological effects. During early vertebrate development, estrogen receptor signaling is critical for many different physiologic responses, including ner