Zobrazeno 1 - 10
of 35
pro vyhledávání: '"Leah C. Wehmas"'
Autor:
Victoria Ledbetter, Scott Auerbach, Logan J. Everett, Beena Vallanat, Anna Lowit, Gregory Akerman, William Gwinn, Leah C. Wehmas, Michael F. Hughes, Michael Devito, J. Christopher Corton
Publikováno v:
Frontiers in Toxicology, Vol 6 (2024)
Current methods for cancer risk assessment are resource-intensive and not feasible for most of the thousands of untested chemicals. In earlier studies, we developed a new approach methodology (NAM) to identify liver tumorigens using gene expression b
Externí odkaz:
https://doaj.org/article/b05c465a5b4645b5b3f97f1d7d895f25
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Formalin fixation of biological specimens damages nucleic acids and limits their use in genomic analyses. Previously, we showed that RNA isolation with an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of f
Externí odkaz:
https://doaj.org/article/c82f8591c92b4bb0a366519a2cd4a31f
Autor:
Aero Renyer, Krishna Ravindra, Barbara A. Wetmore, Jermaine L. Ford, Michael DeVito, Michael F. Hughes, Leah C. Wehmas, Denise K. MacMillan
Publikováno v:
Toxics, Vol 11, Iss 12, p 951 (2023)
Few studies are available on the environmental and toxicological effects of perfluoroalkyl ether carboxylic acids (PFECAs), such as GenX, which are replacing legacy PFAS in manufacturing processes. To collect initial data on the toxicity and toxicoki
Externí odkaz:
https://doaj.org/article/f755faf0b693462dbddd645d9ae1fec7
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 883-894 (2022)
Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples wi
Externí odkaz:
https://doaj.org/article/abd933fa85be4600a08e1d6386fa3df4
Autor:
Justin M. Conley, Christy S. Lambright, Nicola Evans, Elizabeth Medlock-Kakaley, Donna Hill, James McCord, Mark J. Strynar, Leah C. Wehmas, Susan Hester, Denise K. MacMillan, L. Earl Gray, Jr.
Publikováno v:
Environment International, Vol 160, Iss , Pp 107056- (2022)
Nafion byproduct 2 (NBP2) is a polyfluoroalkyl ether sulfonic acid that was recently detected in surface water, drinking water, and human serum samples from monitoring studies in North Carolina, USA. We orally exposed pregnant Sprague-Dawley rats to
Externí odkaz:
https://doaj.org/article/a02a3d000c884df0b141b0a9e57a0cf2
Autor:
Leah C. Wehmas, Catherine Anders, Jordan Chess, Alex Punnoose, Cliff B. Pereira, Juliet A. Greenwood, Robert L. Tanguay
Publikováno v:
Toxicology Reports, Vol 2, Iss C, Pp 702-715 (2015)
Engineered metal oxide nanoparticles (MO NPs) are finding increasing utility in the medical field as anticancer agents. Before validation of in vivo anticancer efficacy can occur, a better understanding of whole-animal toxicity is required. We compar
Externí odkaz:
https://doaj.org/article/452e707c4092461c921d4c3a4dbe1c4a
Publikováno v:
Toxicology reports. 9
Formalin-fixed paraffin-embedded (FFPE) samples are the only remaining biological archive for many toxicological and clinical studies, yet their use in genomics has been limited due to nucleic acid damage from formalin fixation. Older FFPE samples wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::596c38208f77365328eac9c67492a185
https://pubmed.ncbi.nlm.nih.gov/36518475
https://pubmed.ncbi.nlm.nih.gov/36518475
Publikováno v:
Scientific reports. 12(1)
Formalin fixation of biological specimens damages nucleic acids and limits their use in genomic analyses. Previously, we showed that RNA isolation with an organocatalyst (2-amino-5-methylphenyl phosphonic acid, used to speed up reversal of formalin-i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e1db3cf8dc0d6d7f1653ffd6e8f88ba7
https://pubmed.ncbi.nlm.nih.gov/35443772
https://pubmed.ncbi.nlm.nih.gov/35443772
Autor:
Leah C. Wehmas, Charles E. Wood, Gail M. Nelson, Susan D. Hester, Carole L. Yauk, Brian N. Chorley
Publikováno v:
Toxicol Sci
Formalin-fixed paraffin-embedded (FFPE) tissues provide an important resource for toxicogenomic research. However, variability in the integrity or quality of RNA obtained from archival FFPE specimens can lead to unreliable data and wasted resources,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b89cb4b333c7ae5675320dbff7f149c
https://doi.org/10.1093/toxsci/kfz113
https://doi.org/10.1093/toxsci/kfz113
Autor:
Adam Swank, Emily Wheaton, Charles E. Wood, Tamara Tal, Leah C. Wehmas, Tara R. Catron, Drake Phelps, James McCord, Jon R. Sobus, Nichole E. Brinkman, Mark J. Strynar, Randolph R. Singh, Scott P. Keely
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Estrogenic chemicals are widespread environmental contaminants associated with diverse health and ecological effects. During early vertebrate development, estrogen receptor signaling is critical for many different physiologic responses, including ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38ee8f2879de3541c1bad09b8e778272
http://link.springer.com/article/10.1038/s41598-019-43346-9
http://link.springer.com/article/10.1038/s41598-019-43346-9