Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Leah C. Jimmerson"'
Autor:
Kristina M Brooks, Jose R Castillo-Mancilla, Mary Morrow, Samantha Mawhinney, Sarah E Rowan, David Wyles, Joshua Blum, Ryan Huntley, Lana Salah, Arya Tehrani, Leah C Jimmerson, Laura Roon, Lane R Bushman, Peter L Anderson, Jennifer J Kiser
Publikováno v:
J Antimicrob Chemother
Background Sofosbuvir is converted to its active form, 007 triphosphate (007-TP), within cells. To date, the association between treatment adherence and 007-TP in dried blood spots (DBS) and factors that influence this relationship remain unknown. Ob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07af73a1960d610d4a8b78fb133435e3
https://pubmed.ncbi.nlm.nih.gov/35194648
https://pubmed.ncbi.nlm.nih.gov/35194648
Autor:
Marion Koopmans, Jennifer J. Kiser, Leah C. Jimmerson, Georgina I. Aron, Noreen Mumtaz, Lane R. Bushman, Jeroen J. A. van Kampen, Chantal Reusken
Publikováno v:
Antiviral Research, 146, 161-163. Elsevier
The recent epidemic of Zika virus (ZIKV) in the Americas and its association with fetal and neurological complications has shown the need to develop a treatment. Repurposing of drugs that are already FDA approved or in clinical development may shorte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4a10e7126b30fd0027e2cddba450769
https://doi.org/10.1016/j.antiviral.2017.09.004
https://doi.org/10.1016/j.antiviral.2017.09.004
Autor:
Lane R. Bushman, Peter L. Anderson, Joseph E. Rower, Jennifer J. Kiser, Jia-Hua Zheng, Leah C. Jimmerson, Ariel Hodara, Xinhui Chen
Publikováno v:
Antimicrobial Agents and Chemotherapy. 59:7671-7679
Sofosbuvir (SOF) is a highly efficacious and well-tolerated uridine nucleotide analog that inhibits the hepatitis C virus (HCV) NS5B polymerase enzyme. SOF is administered as a prodrug, which undergoes intracellular phosphorylation by host enzymes to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88615008b825652675e51cc70c72e9ae
https://doi.org/10.1128/aac.01693-15
https://doi.org/10.1128/aac.01693-15
Autor:
Joseph E. Rower, Peter L. Anderson, Jia-Hua Zheng, Michelle L. Ray, Jennifer J. Kiser, Lane R. Bushman, Leah C. Jimmerson, Brandon Klein
Publikováno v:
Journal of Chromatography B. :163-172
Ribavirin (RBV) is a nucleoside analog used to treat a variety of DNA and RNA viruses. RBV undergoes intracellular phosphorylation to a mono- (MP), di- (DP), and triphosphate (TP). The phosphorylated forms have been associated with the mechanisms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f699767cd3520ba21a9098b86c849a36
https://doi.org/10.1016/j.jchromb.2014.11.032
https://doi.org/10.1016/j.jchromb.2014.11.032
To develop and validate a method for the simultaneous measurement of adenosine, guanosine, and inosine derived from mono (MP) and triphosphate (TP) forms in peripheral blood mononuclear cells (PBMCs), red blood cells (RBCs) and dried blood spots (DBS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddf30f0cba3f139fc29981a0027c768e
https://europepmc.org/articles/PMC5177511/
https://europepmc.org/articles/PMC5177511/
Autor:
Zayani Sims, Carolyn W. Clayton, Eric G. Meissner, Jennifer J. Kiser, Samantha MaWhinney, Leah C. Jimmerson, Shyamasundaran Kottilil
Publikováno v:
Antiviral research. 138
Ribavirin (RBV), a purine analog, causes hemolytic anemia in some patients. In vitro, anemia appears to result from depletion of endogenous purines, but there are limited data in vivo. Single nucleotide polymorphisms in the gene encoding the inosine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b349bba2ee9208854a94fdcb056356a
https://pubmed.ncbi.nlm.nih.gov/27956135
https://pubmed.ncbi.nlm.nih.gov/27956135
Autor:
Jacob A. Langness, Zayani Sims, Jennifer J. Kiser, Eric G. Meissner, Aimee E. Truesdale, Leah C. Jimmerson, Thomas J. Urban, Christina L. Aquilante, Fafa Baouchi-Mokrane, Shyam Kottilil, Ariel Hodara
Publikováno v:
Journal of clinical pharmacology. 57(1)
Individuals with lower inosine triphosphatase (ITPA) enzyme activity have a reduced likelihood of experiencing hemolytic anemia during hepatitis C virus (HCV) treatment containing ribavirin (RBV). Because ITPA degrades purines and RBV is a purine ana
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdd102910e051d297ae23fe77e6b0ef7
https://pubmed.ncbi.nlm.nih.gov/27349952
https://pubmed.ncbi.nlm.nih.gov/27349952
Autor:
Liviawati Sutjandra Wu, David Z. D'Argenio, Leah C. Jimmerson, Jennifer J. Kiser, Christine E. MacBrayne
Publikováno v:
CPT: Pharmacometrics & Systems Pharmacology
Ribavirin remains an important component of hepatitis C treatment in certain clinical scenarios, but it causes hemolytic anemia. A quantitative understanding of the ribavirin exposure-anemia relationship is important in dose individualization/optimiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cd7841b5178af76f3c09f662958af5
https://pubmed.ncbi.nlm.nih.gov/26933517
https://pubmed.ncbi.nlm.nih.gov/26933517
Autor:
Jennifer J. Kiser, Anu Osinusi, Joseph E. Rower, Eric G. Meissner, Pamela Wolfe, John G. McHutchison, Shyamasundaran Kottilil, Lane R. Bushman, Tess Petersen, Zayani Sims, Leah C. Jimmerson
Objectives Ribavirin concentrations may impact hepatitis C virus (HCV) treatment outcome. We modelled ribavirin serum and intracellular ribavirin monophosphate (RBV-MP) and ribavirin triphosphate (RBV-TP) pharmacokinetics in red blood cells (RBC) usi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fce9bc2a2883b5654b7ac0b238e501d5
https://europepmc.org/articles/PMC4542804/
https://europepmc.org/articles/PMC4542804/
Autor:
Jia-Hua Zheng, Peter L. Anderson, Lane R. Bushman, Leah C. Jimmerson, Christine E. MacBrayne, Jennifer J. Kiser
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 944
Efficient, inexpensive and sensitive assays for the measurement of drugs are of interest for pharmacokinetic and pharmacodynamics (PK–PD) analysis. Dried blood spots (DBS) are a unique bioanaltyical matrix with the potential to fulfill this interes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de9af1a1a396189c8eedeec497e2b302
https://pubmed.ncbi.nlm.nih.gov/24291608
https://pubmed.ncbi.nlm.nih.gov/24291608