Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Leah C. Graham"'
Publikováno v:
BMC Genomics, Vol 20, Iss 1, Pp 1-14 (2019)
Abstract Background The incidence of dementia and cognitive decline is increasing with no therapy or cure. One of the reasons treatment remains elusive is because there are various pathologies that contribute to age-related cognitive decline. Specifi
Externí odkaz:
https://doaj.org/article/3449a7a91dc84316826634288649313d
Autor:
Hongtian Yang, Leah C. Graham, Alaina M. Reagan, Weronika A. Grabowska, William H. Schott, Gareth R. Howell
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-18 (2019)
Abstract Background Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It is increasingly recog
Externí odkaz:
https://doaj.org/article/9ac362a21d3b4c8ab79a191344112566
Autor:
Alaina M, Reagan, Karen E, Christensen, Leah C, Graham, Amanda A, Bedwell, Kierra, Eldridge, Rachael, Speedy, Lucas L, Figueiredo, Scott C, Persohn, Teodoro, Bottiglieri, Kwangsik, Nho, Michael, Sasner, Paul R, Territo, Rima, Rozen, Gareth R, Howell
Publikováno v:
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 42(12)
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer's disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate red
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b777dfaf3b327ed352bb333f71cdea06
https://pubmed.ncbi.nlm.nih.gov/36050860
https://pubmed.ncbi.nlm.nih.gov/36050860
Autor:
Alaina M Reagan, Karen E Christensen, Leah C Graham, Amanda A Bedwell, Kierra Eldridge, Rachael Speedy, Lucas L Figueiredo, Scott C Persohn, Teodoro Bottiglieri, Kwangsik Nho, Michael Sasner, Paul R Territo, Rima Rozen, Gareth R Howell
Publikováno v:
Journal of Cerebral Blood Flow & Metabolism. 42:2333-2350
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7482d7ee3029e817139cb404a3264cea
https://doi.org/10.1177/0271678x221122644
https://doi.org/10.1177/0271678x221122644
Autor:
Alaina M. Reagan, Karen E. Christensen, Leah C. Graham, Amanda A. Bedwell, Kierra Eldridge, Rachael Speedy, Lucas L. Figueiredo, Scott C. Persohn, Teodoro Bottiglieri, Michael Sasner, Paul R. Territo, Rima Rozen, Gareth R. Howell
Vascular contributions to cognitive impairment and dementia (VCID) particularly Alzheimer’s disease and related dementias (ADRDs) are increasing; however, mechanisms driving cerebrovascular decline are poorly understood. Methylenetetrahydrofolate r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a495d9decd9314e5a8bd0cf4d7825317
https://doi.org/10.1101/2021.12.16.472805
https://doi.org/10.1101/2021.12.16.472805
Autor:
Ileana Soto, Leah C Graham, Hannah J Richter, Stephen N Simeone, Jake E Radell, Weronika Grabowska, W Keith Funkhouser, Megan C Howell, Gareth R Howell
Publikováno v:
PLoS Biology, Vol 13, Iss 10, p e1002279 (2015)
Aging is the major risk factor for neurodegenerative diseases such as Alzheimer's disease, but little is known about the processes that lead to age-related decline of brain structures and function. Here we use RNA-seq in combination with high resolut
Externí odkaz:
https://doaj.org/article/65bce2b7791442df845259dc45380d4a
Autor:
Harriet M Jackson, Kristen D Onos, Keating W Pepper, Leah C Graham, Ellen C Akeson, Candice Byers, Laura G Reinholdt, Wayne N Frankel, Gareth R Howell
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0125897 (2015)
Alzheimer's disease (AD) is a leading cause of dementia in the elderly and is characterized by amyloid plaques, neurofibrillary tangles (NFTs) and neuronal dysfunction. Early onset AD (EOAD) is commonly caused by mutations in amyloid precursor protei
Externí odkaz:
https://doaj.org/article/0efb9067855e48c395be5c4e99ae6fa3
Publikováno v:
eNeuro
Age-related cognitive decline and many dementias involve complex interactions of both genetic and environmental risk factors. Recent evidence has demonstrated a strong association of obesity with the development of dementia. Furthermore, white matter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::408f6c39c4f4fd0e92ca71fdbe48a370
https://pubmed.ncbi.nlm.nih.gov/32273396
https://pubmed.ncbi.nlm.nih.gov/32273396
Autor:
Ravi S. Pandey, Christoph Preuss, Asli Uyar, Gareth R. Howell, Gregory W. Carter, Leah C. Graham
Publikováno v:
Molecular Neurodegeneration
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-15 (2019)
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-15 (2019)
Background New genetic and genomic resources have identified multiple genetic risk factors for late-onset Alzheimer’s disease (LOAD) and characterized this common dementia at the molecular level. Experimental studies in model organisms can validate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10c515fda7f91403274367612bafc89f
Autor:
William H. Schott, Weronika A. Grabowska, Hongtian Yang, Alaina M. Reagan, Gareth R. Howell, Leah C. Graham
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-18 (2019)
Journal of Neuroinflammation
Journal of Neuroinflammation
Background Environmental factors are critical in the development of age-related cognitive decline and dementia. A western diet (WD) can cause nutrient deficiency and inflammation that could impact cognition directly. It is increasingly recognized tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c13b374beb2815d25b76bc7883196f08
https://doi.org/10.1186/s12974-019-1527-z
https://doi.org/10.1186/s12974-019-1527-z