Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leah C Dorman"'
Autor:
Elvira Mennillo, Yang Joon Kim, Gyehyun Lee, Iulia Rusu, Ravi K. Patel, Leah C. Dorman, Emily Flynn, Stephanie Li, Jared L. Bain, Christopher Andersen, Arjun Rao, Stanley Tamaki, Jessica Tsui, Alan Shen, Madison L. Lotstein, Maha Rahim, Mohammad Naser, Faviola Bernard-Vazquez, Walter Eckalbar, Soo-jin Cho, Kendall Beck, Najwa El-Nachef, Sara Lewin, Daniel R. Selvig, Jonathan P. Terdiman, Uma Mahadevan, David Y. Oh, Gabriela K. Fragiadakis, Angela Pisco, Alexis J. Combes, Michael G. Kattah
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Ulcerative colitis (UC) is driven by immune and stromal subsets, culminating in epithelial injury. Vedolizumab (VDZ) is an anti-integrin antibody that is effective for treating UC. VDZ is known to inhibit lymphocyte trafficking to the intest
Externí odkaz:
https://doaj.org/article/0ea20593138a4ffda5f1bf392dc9a45e
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Microglia remodel synapses and engulf apoptotic cells. The molecular program underlying these distinct functions are unclear. Here, the authors identify distinct microglial subsets associated with synaptic vs. neurogenic regions of the developing zeb
Externí odkaz:
https://doaj.org/article/827e8387a61f43bfa0b99a363397af48
Autor:
Jerika J. Barron, Nicholas M. Mroz, Sunrae E. Taloma, Madelene W. Dahlgren, Jorge Ortiz-Carpena, Leah C. Dorman, Ilia D. Vainchtein, Caroline C. Escoubas, Ari B. Molofsky, Anna V. Molofsky
Publikováno v:
bioRxiv
The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::466609c5840600ffa1fa935483ea97bc
https://doi.org/10.1101/2023.03.16.532850
https://doi.org/10.1101/2023.03.16.532850
Autor:
Elvira Mennillo, Yang Joon Kim, Iulia Rusu, Gyehyun Lee, Leah C. Dorman, Faviola Bernard-Vazquez, Jared L. Bain, Ravi Patel, Christopher Andersen, Arjun Rao, Stanley Tamaki, Jessica Tsui, Alan Shen, Mohammad Naser, Walter Eckalbar, Soo-jin Cho, Kendall Beck, Najwa El-Nachef, Sara Lewin, Daniel R Selvig, Jonathan P Terdiman, Uma Mahadevan, David Y. Oh, Gabriela K. Fragiadakis, Angela Pisco, Alexis J. Combes, Michael G. Kattah
Publikováno v:
bioRxiv
Ulcerative colitis (UC) is an inflammatory intestinal disorder driven by mucosal immune and stromal subsets, culminating in epithelial injury. Vedolizumab (VDZ) is an anti-integrin monoclonal antibody that is effective for treating UC. VDZ is thought
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e27186b79baedb645bd0b8ac9f32482
https://europepmc.org/articles/PMC9882264/
https://europepmc.org/articles/PMC9882264/
Autor:
Rafael T. Han, Ilia D. Vainchtein, Johannes C.M. Schlachetzki, Frances S. Cho, Leah C. Dorman, Eunji Ahn, Dong Kyu Kim, Jerika J. Barron, Hiromi Nakao-Inoue, Ari B. Molofsky, Christopher K. Glass, Jeanne T. Paz, Anna V. Molofsky
Publikováno v:
The Journal of experimental medicine, vol 220, iss 2
Microglia are critical regulators of brain development that engulf synaptic proteins during postnatal synapse remodeling. However, the mechanisms through which microglia sense the brain environment are not well defined. Here, we characterized the reg
Autor:
Ryan Chan, Joshua P Hedtke, Michael T Chang, Kristen M Omi, Namrata Kakade, William Y. Luo, Yurianna Hou, Gloria Chin Young, Sunjong Ji, Mai Abdusamad, Amy Ngo, Maggie M Yung, Carissa Chan, Sharon Lee, Mark R Murata, Ashwin Shinde, Jason P Xu, Angelica C Ayala, Emily Jin Kyung Kim, Elitzander Alegria‐Leal, Phuong Vo, Yuan Wan, Vivian K Chen, Raghav Goyal, Anabel Resendiz, Harin B Parikh, Jaime S Tan, Leah C Dorman, Annisa N Soeboer, Seethim Naicker, Pratyush Kandimalla, Petros S Dertsakyan, Faith A Hobby, Beatrice J Sun, Karen Hoi, Megha Pokhriyal, C Kimberly Tsui, Nguyen Khoi Le, Umar Chaudhary, Patrick Chin, Woo Kyeom Kim, Mengshi He, David A Sanville, Utpal Banerjee, Christine Sutanto, Tiffany Luu, Joshua Lin, Tony Yao, Josephine Liu, Janani Muthaiya, Ravinder Kaur, Steven V. Pham, Andrea Vega-Loza, Mia Lim, Nataliya S Balashova, Adam T Quaal, Hnin Hlaing, Patrick A. Truong, Bryan Stender, Harmanjit Bassi, Erwin Feng, Yuxuan Wang, Sarah Salarkia, Rina H Nguyen, Gloria Lam, Garuem Sin, Seong Ah Kim, Sindhuja Godavarthi, Jialing Li, Eileen Hu, Cindy La, Elaine Sang, Jun Ho Chung, Jinhua Shen, Celesti Hao, Josh Mytych, Elliott Wu, Jin Hee Kim, Duy Tran, Neel Chari, Andie O'Laughlin, Christopher J Smith, Mona Abutouk, Chak Lon Kuang, Pei-Hua Tsai, Alisa Sukhina, Li Li, Chongbin He, Daniel Wong, Jahzeel Paguntalan, Emily R Schoen, Edgar Corona, Vivian Yip, Trisha H Patel, Emily Kim, Ira E. Clark, Andrew Char, Guadalupe Ortega Almazan, Asmar Abdul Ghani, Nadiyah Priasti, Duy Q Ngo, Gabrielle Sibal, Sean P Bennion, Stephanie Pang, Vivien W. Ho, Rachel S Distler, Nateli Sama, Josef Madrigal, Maharshi Panchal, Zijie Cai, Ashley C. Hope, Miriam Beyder, Daphne Jin, Steven C Liu, John M. Olson, Janice Ly, Eric Wang, Irene Louie, Wilson Huang, Justin Rafael de la Fuente, Nathan Stutzman, Bilguudei Naranbaatar, Rose Graf, Jonelle Mungcal, Jason Capili, Ziqi Zhou, Kelly M Gu, Julie Ko, Jeffrey A Kho, Amber J Li, Daniel Tran, Cory J. Evans, Jocelyn Woo, Kristen Schnell, Praptee Chowdhury, Chi Ju Lee, Grace J. Lee, Tracy L. Johnson, Nadezhda Riabkova, David Lopatto, Amanda Phan, Mary C Onglatco, Stephanie Huang, Zhiqiao Dong, Sat Kartar Khalsa, Saurin Kadakia, Maique Vo, Jessica Ye, Eric Lin, Darron Miya, Julia A. Ainsworth, Nicholas James, Jonathan Chang, Chloe C Su, Jeffrey Lin, Leslie Jaworski, Jenna Kovsky, Alice Hsu, Michel Chen, Allysen B Ehresman, Ju-Yeon Lee, Talin Golnazarian, Dana Lee, Kai Y Alexander, Jill Zimmerman, Lauren Johnson, Bosco Q Giap, Jamlah Dalie, Jackson K Uriu, Amala John, Osvaldo Acosta, Tebogo Mokwena, Sanan Venkatesh, Brandon L. Tsai, Haris M Akram, Seo-Kyung Oh, Andrea T Fua, Mark A Douglass, Rebecca Yang, Jessica M. Lee, Derek Spitters, Carmen Javier, Alex W Chan, Richard Wong, Ivy H Fu, Connie Y Liu, Parich Tangmatitam, Sena Ji, Claire Park, Arash Ghaffari-Rafi, Vincent T Nguyen, Dorothy Yim, Kush V. Bhatt, Tonatiuh Montoya, Rayna Tian, Vivian Chiu, Malcolm Phung, Victoria Lee, Chinmay Bhoot, Purvi D Patel, Jensen Pak, Puja Yogi, Zhouyang Shen, Nhat-Thi Vo, Bama Charan Mondal, Davis W Popovich, Mane Williams, Oscar M A Del Rio, Alexander J Chassiakos, Ruth Ryu, Zijun Zhao, Renae L Cruz, Yishan Mai, Michael K Wang, Kenneth Chang Chien, Kayla Patel, Jun Wang, Courtney J Cruz, Nicholas J Gills, Alexis Baranoff, Dinali Wijiewarnasurya, Yancey Y Cashell, Iman Hamid, Ashley Hanson, Olivia L Lee, Jasmine Sjarif, Patrick W Chang, Jasmin Johal, Monica Ghaly, Momoko Ishii, Alexandra M Libro, Boyu Cao, Paras Shah, Jennifer Hsueh, Aaron W Bradshaw, Jagteshwar Singh Khatra, Tien M Phan-Everson, Jonathan Lai, David J. Lim, Na Eun Jeon, Caleb Kim, Hyun Wook Kim, Hannah Kim, Sean Full, Tierney G Brannigan, Inho Chang, Suhas P Dasari, Emily R Dennis, Ceejay Lee, Alexander Zai, Christine Zhang, Ayse Elif Kesaf, Ralph Albert, Rebecca M Barber, Shijia W Lu, Austin Ma, Spencer S Hu, Ipsita Dey, Hee Jong Kim, Nancy Ruano, Timothy C Voros, Sarah M. Kamel, Kimberly L Yan, Gah-Eun Jang, Dallas L Mould, Eduardo Hernandez, Sahra M Hosseinian, Iris Chen, Chon Ao, Cindy K Trac, Eric Y Du, Sam Law, Ysrael K Hernandez, Jeffrey S. Zhao, Angad Beniwal, Patricia Yeo, Vina Tran, James R. Lee, Manny Sosa, Zheying Chen, Alec Estrada, Cristian Sosa, Kevin Herrera, Mina Mohammadi, Rina Watanabe, Timothy Chai, Huy Nguyen, Dong Yeon Lee, Vishaal Yepuri, Melanie Huynh, Kyle Marik, Thao T T Nguyen, Xiao X Zhang, Jamie A Ngo, Anh Nguyen, Colton Bracken, Brandon Wei, Brian Aguirre, Sayonika Mohanta, Jeffrey C. Wang, Casey Shapiro, Sonia Gill, Fred Rong, Lauren Petersen, Pingdi Huang, Alexander Grunfeld, Sang Kuk Lee, An N Ha, Kevin Nishida, Shraddha Kumar, Terrence C Lee, Ariano Abbasi, Jenny Summapund, Karl Querubin, Siman Wei, Hanning Xing, Evan Yang, Liset Contreras, Sahar Yaftaly, Matthew Wilson, Ken Siangchin, Brian Kit, Mallory R Neebe, Irvin C Lien, Julia E Petersen, Jonathan Woo, Kaitlyn Honeychurch, Jesse Juarez, Stephen Chang, Raymond Zhou, Cristian Medina, Sean Louise G Laput, Jason T. Lee, Nguon L Tan, Sharon Choi, Natalia C Gutierrez, Zafar S Gill, Kenneth Kim, Jefferson M Dang, Tanveer Salim, Marc Levis-Fitzgerald, Dan Huynh, Joyce Wang, Marsha R Cheng, Lillian Xie, Hannah Markovic, Conny Tran, Mimi Chiang, Vivian Lam, Nick Waite, Ricardo Gray, Jo M Huang
Publikováno v:
G3: Genes|Genomes|Genetics
Undergraduate students participating in the UCLA Undergraduate Research Consortium for Functional Genomics (URCFG) have conducted a two-phased screen using RNA interference (RNAi) in combination with fluorescent reporter proteins to identify genes im
Autor:
Leah C, Dorman, Phi T, Nguyen, Caroline C, Escoubas, Ilia D, Vainchtein, Yinghong, Xiao, Peter V, Lidsky, Haruna, Nakajo, Nicholas J, Silva, Christian, Lagares-Linares, Ellen Y, Wang, Sunrae E, Taloma, Beatriz, Cuevas, Hiromi, Nakao-Inoue, Brianna M, Rivera, Bjoern, Schwer, Carlo, Condello, Raul, Andino, Tomasz J, Nowakowski, Anna V, Molofsky
Publikováno v:
bioRxiv : the preprint server for biology.
Microglia, the innate immune cells of the brain, are exquisitely sensitive to dynamic changes in the neural environment. Using single cell RNA sequencing of the postnatal somatosensory cortex during topographic remapping, we identified a type I inter
Publikováno v:
Nature communications, vol 12, iss 1
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Microglia are brain resident macrophages that play vital roles in central nervous system (CNS) development, homeostasis, and pathology. Microglia both remodel synapses and engulf apoptotic cell corpses during development, but whether unique molecular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a97e0e45ad477a413c0d6bcc7b519761
https://escholarship.org/uc/item/0h10h896
https://escholarship.org/uc/item/0h10h896
Autor:
Rafael T. Han, Jerika T. Barron, Leah C. Dorman, Hiromi Nakao-Inoue, Ilia D. Vainchtein, Anna V. Molofsky, Ari B. Molofsky, Jeanne T. Paz, Eunji Ahn, Johannes C. M. Schlachetzki, Akshaj Joshi, Christopher K. Glass, Frances S. Cho, Tessa Johung
SummaryMicroglia are key remodelers of neuronal synapses during brain development, but the mechanisms that regulate this process and its ultimate impact on neural circuit function are not well defined. We previously identified the IL-1 family cytokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04fe8a65915ae9e6a0996b30fefba0a9
https://doi.org/10.1101/2021.08.05.455250
https://doi.org/10.1101/2021.08.05.455250
SummaryMicroglia are brain resident macrophages that play vital roles in central nervous system (CNS) development, homeostasis, and pathology. Microglia both remodel synapses and engulf apoptotic cell corpses during development, but whether unique mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::26e40f34c23ad56f1bb5753bbdf3a461
https://doi.org/10.1101/2021.05.08.443268
https://doi.org/10.1101/2021.05.08.443268