Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Leah C Beauchamp"'
Autor:
Sanjida Mir, Ryan J. Keenan, Romke Bron, Cameron J. Nowell, Catriona McLean, Leah C. Beauchamp, Laura J. Vella, Brian Dean, Daniel Hoyer, Laura H. Jacobson
Publikováno v:
Medicine in Drug Discovery, Vol 24, Iss , Pp 100202- (2024)
Hypocretin (Hcrtr, HCRTR) / orexin (OX) receptors modulate a range of neurobiological functions and are drug targets for several disorders. Mapping the distribution of receptors in the brain can inform their function and guide targeting of specific d
Externí odkaz:
https://doaj.org/article/9f4c6bbb7e4a49a9a8786c108d2f560f
Autor:
Paul Trlin, Jenny Gong, Katie K. N. Tran, Vickie H. Y. Wong, Pei Ying Lee, Anh Hoang, Da Zhao, Leah C. Beauchamp, Jeremiah K. H. Lim, Andrew Metha, Kevin J. Barnham, David I. Finkelstein, Bang V. Bui, Phillip Bedggood, Christine T. O. Nguyen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Retinal hyperspectral imaging (HSI) is a non-invasive in vivo approach that has shown promise in Alzheimer’s disease. Parkinson’s disease is another neurodegenerative disease where brain pathobiology such as alpha-synuclein and iron over
Externí odkaz:
https://doaj.org/article/4922d8416bbd4e5ca8336a9df43afadf
Autor:
Caroline Wasén, Leah C. Beauchamp, Julia Vincentini, Shuqi Li, Danielle S. LeServe, Christian Gauthier, Juliana R. Lopes, Thais G. Moreira, Millicent N. Ekwudo, Zhuoran Yin, Patrick da Silva, Rajesh K. Krishnan, Oleg Butovsky, Laura M. Cox, Howard L. Weiner
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract The gut microbiota and microglia play critical roles in Alzheimer’s disease (AD), and elevated Bacteroides is correlated with cerebrospinal fluid amyloid-β (Aβ) and tau levels in AD. We hypothesize that Bacteroides contributes to AD by m
Externí odkaz:
https://doaj.org/article/5a13ffd6448641528a8fa807f7ea2f20
Autor:
Tracy D. Zhang, Scott C. Kolbe, Leah C. Beauchamp, Ella K. Woodbridge, David I. Finkelstein, Emma L. Burrows
Publikováno v:
Biomedicines, Vol 10, Iss 12, p 3026 (2022)
The prodromal phase of Parkinson’s disease (PD) is characterised by many non-motor symptoms, and these have recently been posited to be predictive of later diagnosis. Genetic rodent models can develop non-motor phenotypes, providing tools to identi
Externí odkaz:
https://doaj.org/article/46cbef32bf8f4ea196c95ffeebe7353d
Autor:
Leah C. Beauchamp, Jacky Chan, Lin W. Hung, Benjamin S. Padman, Laura J. Vella, Xiang M. Liu, Bradley Coleman, Ashley I. Bush, Michael Lazarou, Andrew F. Hill, Laura Jacobson, Kevin J. Barnham
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-12 (2018)
Abstract Parkinson’s disease is diagnosed upon the presentation of motor symptoms, resulting from substantial degeneration of dopaminergic neurons in the midbrain. Prior to diagnosis, there is a lengthy prodromal stage in which non-motor symptoms,
Externí odkaz:
https://doaj.org/article/44dfb79e8bff4f45be71e09c33c7e944
Autor:
Leah C. Beauchamp, Xiang M. Liu, Laura J. Vella, Paul A. Adlard, Ashley I. Bush, David I. Finkelstein, Kevin J. Barnham
Publikováno v:
Neurotherapeutics. 19:1966-1975
Hyposmia is a prevalent prodromal feature of Parkinson’s disease (PD), though the neuropathology that underlies this symptom is poorly understood. Unlike the substantia nigra, the status of metal homeostasis in the olfactory bulbs has not been char
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::997fd1657c6f22064bd734bdca96598f
https://doi.org/10.1007/s13311-022-01300-0
https://doi.org/10.1007/s13311-022-01300-0
Autor:
Isaline Mees, Shanshan Li, Leah C Beauchamp, Kevin J Barnham, Mathias Dutschmann, Anthony J Hannan, Thibault Renoir
Publikováno v:
Human Molecular Genetics. 31:1997-2009
Tubulin-associated unit (Tau) is a microtubule-associated protein, whose abnormal phosphorylation and deposition in the brain characterizes a range of neurodegenerative diseases called tauopathies. Recent clinical (post-mortem) and pre-clinical evide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f89d9b96c9af612d407483cd52e67d63
https://doi.org/10.1093/hmg/ddac001
https://doi.org/10.1093/hmg/ddac001
Autor:
Xiang M. Liu, Amelia Sedjahtera, Leah C. Beauchamp, Paul A. Adlard, Ashley I. Bush, Laura J Vella, Mirjana Bogeski, Kevin J. Barnham
Publikováno v:
Journal of Alzheimer's Disease. 77:1705-1715
Background: Alterations in the methionine cycle and abnormal tau phosphorylation are implicated in many neurodegenerative diseases, including Alzheimer’s disease and frontotemporal dementia. rTg4510 mice express mutant human P301L tau and are a mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc5fb2fb35d4cb4337f727614d5c628e
https://doi.org/10.3233/jad-200756
https://doi.org/10.3233/jad-200756
Autor:
Catriona McLean, Kevin J. Barnham, Adityas Purnianto, Gavin E. Reid, Huaqi Su, Andrew F. Hill, Tiana Koukoulis, Leah C. Beauchamp, Laura J Vella, Colin L. Masters, Lesley Cheng, Ashley I. Bush
Publikováno v:
Alzheimer's & Dementia. 16
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::273add060d85e4eddd699a1a0537b527
https://doi.org/10.1002/alz.045561
https://doi.org/10.1002/alz.045561
Autor:
Victor L. Villemagne, Leah C. Beauchamp, Christopher C. Rowe, David Finkelstein, Kevin J. Barnham, Vincent Dore, Ashley I. Bush
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020)
Motor deficits in parkinsonism are caused by degeneration of dopaminergic nigral neurons. The success of disease-modifying therapies relies on early detection of the underlying pathological process, leading to early interventions in the disease pheno
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed013e6d0b9112aa566b489e3f731212
http://europepmc.org/articles/PMC7584593
http://europepmc.org/articles/PMC7584593