Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Leah C, Konkol"'
Autor:
Alice L. Rodriguez, P. Jeffrey Conn, Allison R. Gregro, Michael Bubser, Mark E. Dugan, Colleen M. Niswender, Leah C. Konkol, Michael W. Wood, Darren W. Engers, Craig W. Lindsley, Jeanette L. Bertron, Bruce J. Melancon, Sean R. Bollinger, Thomas M. Bridges, Samantha E. Yohn, Vincent B. Luscombe, Andrew S. Felts, Michael R. Wood, Carrie K. Jones, Nicholas J. Brandon, Katrina A. Bollinger
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 29:1714-1718
This letter describes progress towards an M4 PAM preclinical candidate that resulted in the discovery of VU6005806/AZN-00016130. While the thieno[2,3-c]pyridazine core has been a consistent feature of key M4 PAMs, no work had previously been reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49ea6005ae21bf03b498cfa06332687e
https://doi.org/10.1016/j.bmcl.2019.05.026
https://doi.org/10.1016/j.bmcl.2019.05.026
Autor:
Darren W, Engers, Bruce J, Melancon, Allison R, Gregro, Jeanette L, Bertron, Sean R, Bollinger, Andrew S, Felts, Leah C, Konkol, Michael R, Wood, Katrina A, Bollinger, Vincent B, Luscombe, Alice L, Rodriguez, Carrie K, Jones, Michael, Bubser, Samantha E, Yohn, Michael W, Wood, Nicholas J, Brandon, Mark E, Dugan, Colleen M, Niswender, P Jeffrey, Conn, Thomas M, Bridges, Craig W, Lindsley
Publikováno v:
Bioorganicmedicinal chemistry letters. 29(14)
This letter describes progress towards an M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cf31ffd80bc2a0d63aa6c41af28d67b3
https://pubmed.ncbi.nlm.nih.gov/33218899
https://pubmed.ncbi.nlm.nih.gov/33218899
Publikováno v:
Scaffold Hopping in Medicinal Chemistry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95810aae97584f8853e2042dbe782000
https://doi.org/10.1002/9783527665143.ch16
https://doi.org/10.1002/9783527665143.ch16
Autor:
Cynthia B. Berry, Leah C. Konkol, Leslie N. Aldrich, Miranda So, Craig W. Lindsley, Brittney S. Bates
Publikováno v:
European Journal of Organic Chemistry. 2013:4215-4218
Herein, we describe the enantioselective construction of the 12-membered macrocyclic pyrrole core 4 of marineosin A in 5.1% overall yield from (S)-propylene oxide. The route features a key Stetter reaction to install a 1,4-diketone, which is then sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53d666dc783a4f37200a133330538d51
https://doi.org/10.1002/ejoc.201300643
https://doi.org/10.1002/ejoc.201300643
Publikováno v:
Tetrahedron Letters. 54:1645-1648
In this Letter, we describe a novel approach for the general and enantioselective synthesis of a diverse array of small to large 1-azabicyclo[m.n.0]alkyl ring systems with an embedded olefin handle for further functionalization. The stereochemistry i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::57e861802911ad6a80edf6310b80c455
https://doi.org/10.1016/j.tetlet.2013.01.041
https://doi.org/10.1016/j.tetlet.2013.01.041
Publikováno v:
Angewandte Chemie. 123:10105-10108
Lost in rotation: the concise strategy of the first enantioselective total synthesis of bismurrayaquinone A utilized traceless stereochemical exchange to form an enantioenriched biphenyl core that was elaborated in a bidirectional manner to the natur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dad83c2c36027114704eedbc6d52c27
https://doi.org/10.1002/ange.201104726
https://doi.org/10.1002/ange.201104726
Autor:
Charlotte L. Stern, Carla N. Taylor, Regan J. Thomson, Leah C. Konkol, Christopher T. Avetta, Karen C. Dugan
Publikováno v:
Organic Letters. 10:5621-5624
Diisopropylsilyl bis-enol ethers are shown to be powerful intermediates for the diastereoselective dimerization and cross-coupling of cyclic ketones. The trends observed for the oxidative coupling of a range of different dialkylsilyl bis-enol ethers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36e153743f64edd5d15f1353fed8648
https://doi.org/10.1021/ol802516z
https://doi.org/10.1021/ol802516z
Autor:
Analisa D. Thompson, Frank W. Byers, Julie L. Engers, Colleen M. Niswender, Ryan D. Morrison, Anna L. Blobaum, Alice L. Rodriguez, Carrie K. Jones, Kyle A. Emmitte, J. Scott Daniels, Daryl F. Venable, Matthew T. Loch, P. Jeffrey Conn, Leah C. Konkol, Craig W. Lindsley, Sichen Chang
Publikováno v:
Journal of medicinal chemistry. 58(18)
Previous preclinical work has demonstrated the therapeutic potential of antagonists of the group II metabotropic glutamate receptors (mGlus). Still, compounds that are selective for the individual group II mGlus (mGlu2 and mGlu3) have been scarce. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462c8425cb99f4e7d9c22446e5aa9b77
https://pubmed.ncbi.nlm.nih.gov/26335039
https://pubmed.ncbi.nlm.nih.gov/26335039
A concise, nine-step enantioselective total synthesis of metacycloprodigiosin is reported. The synthesis provides increased step-efficiency over the previous racemic and enantioselective syntheses of this compound. Key features of the work include in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::168bdfcb7b4e61b76b888b50c7ba05e3
https://europepmc.org/articles/PMC4480779/
https://europepmc.org/articles/PMC4480779/
Autor:
Leslie N, Aldrich, Cynthia B, Berry, Brittney S, Bates, Leah C, Konkol, Miranda, So, Craig W, Lindsley
Publikováno v:
European journal of organic chemistry. 2013(20)
Herein, we describe the enantioselective construction of the 12-membered macrocyclic pyrrole core 4 of marineosin A in 5.1% overall yield from (S)-propylene oxide. The route features a key Stetter reaction to install a 1,4-diketone, which is then sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9465dd8a9150889f707fe047644acb40
https://pubmed.ncbi.nlm.nih.gov/24415906
https://pubmed.ncbi.nlm.nih.gov/24415906