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Autor:
Barry D. Hock, Margaret J. Currie, Leah Butt, Liping Goddard, Matthew Strother, Judith L. McKenzie
Publikováno v:
Cancer immunology, immunotherapy : CII. 69(12)
The PD-1-targeting IgG4 antibody pembrolizumab has significant anti-tumor activity in a proportion of stage IV melanoma patients. A subset of patients develop anti-drug antibodies (ADA) which can form immune complexes (IC) with pembrolizumab. Althoug