Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Leah A Vardy"'
Autor:
Phyllis S.Y. Chong, Jing Yuan Chooi, Sze Lynn Julia Lim, Tae-Hoon Chung, Reinhard Brunmeir, Aaron Chung Yong Leow, Sabrina Hui Min Toh, Kalpnaa Balan, Muhamad Irfan Bin Azaman, Zhengwei Wu, Nagavidya Subramaniam, Leah A Vardy, Wee-Joo Chng
Publikováno v:
Haematologica, Vol 109, Iss 6 (2023)
REIIBP is a lysine methyltransferase aberrantly expressed through alternative promoter usage of NSD2 locus in t(4;14)-translocated multiple myeloma (MM). Clinically, t(4;14) translocation is an adverse prognostic factor found in approximately 15% of
Externí odkaz:
https://doaj.org/article/f19e38c9080845be90a8baff6bb37aa2
Autor:
Meng Shi, Hieng Chiong Tie, Mahajan Divyanshu, Xiuping Sun, Yan Zhou, Boon Kim Boh, Leah A Vardy, Lei Lu
Publikováno v:
eLife, Vol 11 (2022)
The hallmark event of the canonical transforming growth factor β (TGFβ) family signaling is the assembly of the Smad-complex, consisting of the common Smad, Smad4, and phosphorylated receptor-regulated Smads. How the Smad-complex is assembled and r
Externí odkaz:
https://doaj.org/article/da9155a42d1d4095a46197d09b6e706a
Autor:
Queenie Wing-Lei Wong, Candida Vaz, Qian Yi Lee, Tian Yun Zhao, Raymond Luo, Stuart K Archer, Thomas Preiss, Vivek Tanavde, Leah A Vardy
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0143235 (2016)
The presence of multiple variants for many mRNAs is a major contributor to protein diversity. The processing of these variants is tightly controlled in a cell-type specific manner and has a significant impact on gene expression control. Here we inves
Externí odkaz:
https://doaj.org/article/195e17d0725547809eef156eb1085c0b
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Arginase (ARG) represents an important evolutionarily conserved enzyme that is expressed by multiple cell types in the skin. Arg acts as the mediator of the last step of the urea cycle, thus providing protection against excessive ammonia under homeos
Externí odkaz:
https://doaj.org/article/bc8ecb0ebe684e58a0a88248184d6e9c
Autor:
Meng-Kwang Marcus Tan, Radoslaw M. Sobota, Esther SM Wong, Leah A. Vardy, Brian Burke, Colin L. Stewart
Increased activity of the mammalian target of rapamycin (mTOR) signalling pathway, a crucial nutrient sensor, exacerbates ageing and ageing-related diseases, including cancer and heart failure. To further elucidate the physiological role of the serin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8114082d8612dc04dfb13ccfbd76ec40
https://doi.org/10.1101/2022.10.13.512080
https://doi.org/10.1101/2022.10.13.512080
Publikováno v:
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences, Vol 8 (2021)
Frontiers in Molecular Biosciences, Vol 8 (2021)
Arginase (ARG) represents an important evolutionarily conserved enzyme that is expressed by multiple cell types in the skin. Arg acts as the mediator of the last step of the urea cycle, thus providing protection against excessive ammonia under homeos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e10c6b8cfda4594187c796ce53c110c0
http://europepmc.org/articles/PMC8589187
http://europepmc.org/articles/PMC8589187
Autor:
Leah A. Vardy, Shatarupa Das, Kazuei Igarashi, Anisa Rahim, John E.A. Common, Takeshi Uemura, Hui Kheng Lim, Vonny I. Leo, Thiam Chye Lim
Publikováno v:
Journal of Investigative Dermatology. 138:2653-2665
Wound healing is a dynamic process involving gene-expression changes that drive re-epithelialization. Here, we describe an essential role for polyamine regulator AMD1 in driving cell migration at the wound edge. The polyamines, putrescine, spermidine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e407fda91615af9f58e92185faa4e7
https://doi.org/10.1016/j.jid.2018.05.029
https://doi.org/10.1016/j.jid.2018.05.029
Autor:
Adam J Reid, Rachel A. Crompton, Leah A. Vardy, Matthew J. Hardman, Helen Williams, Laura Campbell, Jason Wong, Charis R Saville, Sheena M. Cruickshank, Lim Hui Kheng, David M. Ansell
Publikováno v:
Journal of Investigative Dermatology. 142:1206-1216.e8
Nonhealing wounds are a major area of unmet clinical need remaining problematic to treat. Improved understanding of prohealing mechanisms is invaluable. The enzyme arginase1 (ARG1) is involved in prohealing responses, with its role in macrophages bes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6b00266b5f1b890c6360c2bf2b364e8
https://doi.org/10.1016/j.jid.2021.09.009
https://doi.org/10.1016/j.jid.2021.09.009
Autor:
Jia Xu Wang, Shaun W. Lim, Eng Piew Louis Kok, Ashley Jong Ghut Aw, Niranjan Nagarajan, Chenhao Li, Pornchai Kaewsapsak, Boon Hsi Ng, Leah A. Vardy, Meng How Tan, Yue Wan, Yang Shen
The ability to correctly assign structure information to an individual transcript in a continuous and phased manner is critical to understanding RNA function. RNA structure play important roles in every step of an RNA’s lifecycle, however current s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1096eda8e7121ae03b59d455cc477273
https://doi.org/10.1101/2020.06.11.147223
https://doi.org/10.1101/2020.06.11.147223