Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Leah A Santat"'
Publikováno v:
eLife, Vol 8 (2019)
The Notch signaling pathway consists of transmembrane ligands and receptors that can interact both within the same cell (cis) and across cell boundaries (trans). Previous work has shown that cis-interactions act to inhibit productive signaling. Here,
Externí odkaz:
https://doaj.org/article/b511b219e72f4db3bfc0fc86fcd4300d
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4559 (2009)
RNA interference (RNAi) was investigated with the aim of achieving gene silencing with diverse RNAi platforms that include small interfering RNA (siRNA), short hairpin RNA (shRNA) and antisense oligonucleotides (ASO). Different versions of each syste
Externí odkaz:
https://doaj.org/article/c724d9bd21da4cf599308a7347c9ee9f
Autor:
Robert A. Rebres, Melvin I. Simon, Leah A. Santat, William E. Seaman, Elliott M. Ross, Finly Philip, Tamara I. A. Roach, Iain D. C. Fraser, Keng Mean Lin, Lucas Cheadle, Christina Moon, Jamie Liu
Publikováno v:
Journal of Biological Chemistry. 286:942-951
Cross-talk between Gα(i)- and Gα(q)-linked G-protein-coupled receptors yields synergistic Ca(2+) responses in a variety of cell types. Prior studies have shown that synergistic Ca(2+) responses from macrophage G-protein-coupled receptors are primar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f37626920e0d641e4c24a91127824d39
https://doi.org/10.1074/jbc.m110.198200
https://doi.org/10.1074/jbc.m110.198200
Autor:
Leah A. Santat, Michael B. Elowitz, Amit Lakhanpal, Lauren LeBon, Graham A. Anderson, Michelle E. Fontes, Jordi Garcia-Ojalvo, David Sprinzak
Publikováno v:
Nature
The Notch–Delta signalling pathway allows communication between neighbouring cells during development^1. It has a critical role in the formation of ‘fine-grained’ patterns, generating distinct cell fates among groups of initially equivalent nei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f8b557b1763aa10b5abd8877335931c
http://europepmc.org/articles/PMC2886601
http://europepmc.org/articles/PMC2886601
Autor:
Michael B. Elowitz, Lauren LeBon, Nagarajan Nandagopal, Marianne E. Bronner, David Sprinzak, Leah A. Santat
Publikováno v:
Cell
SUMMARY The Notch signaling pathway comprises multiple ligands that are used in distinct biological contexts. In principle, different ligands could activate distinct target programs in signal-receiving cells, but it is unclear how such ligand discrim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c12d6d54fac2546385daafbaab9aba2
http://europepmc.org/articles/PMC6414217
http://europepmc.org/articles/PMC6414217
Autor:
Andreia Maer, Shankar Subramaniam, Qingli Mi, Brian Saunders, Jamie Liu, Leah A. Santat, Xiaocui Zhu, Stephen Aplin Lyon, Grischa Chandy, Kavitha Dhandapani, Melvin I. Simon, Heather M. Bryan, Yuhong Ning, Joelle R. Zavzavadjian, Mi Sook Chang, Nancy A. O'Rourke, Wei Sun Park, Estelle A. Wall, Eileen Fung, Mary Verghese, Adrienne Driver, Genie Lee, Elizabeth Gehrig, James H. Whalen, Sam Couture, Christine Kivork, Baljinder Randhawa, Tobias Meyer, Iain D. C. Fraser
Publikováno v:
Molecular & Cellular Proteomics. 6:413-424
Cellular responses to inputs that vary both temporally and spatially are determined by complex relationships between the components of cell signaling networks. Analysis of these relationships requires access to a wide range of experimental reagents a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::077f827bfe304198531bc30719a63073
https://doi.org/10.1074/mcp.m600437-mcp200
https://doi.org/10.1074/mcp.m600437-mcp200
Autor:
Leah A. Santat, Iain D. C. Fraser, Tamara I. A. Roach, Jamie Liu, Estelle A. Wall, Joelle R. Zavzavadjian, Wei Liu, Marc C. Mumby, Robert A. Rebres
The use of RNA interference to knock down protein phosphatases has proven to be a valuable approach to understanding the functions of these enzymes in mammalian cells. Many protein phosphatases exist as multisubunit and multigene families, which has
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d44b1d30ebbd9da9bc0d6d4fba293ff
https://doi.org/10.1385/1-59745-267-x:261
https://doi.org/10.1385/1-59745-267-x:261
Autor:
Estelle A. Wall, William E. Seaman, Jong Ik Hwang, Leah A. Santat, Melvin I. Simon, Robert A. Rebres, Jamie Liu, Iain D. C. Fraser, Joelle R. Zavzavadjian, Tamara I. A. Roach, Kum Joo Shin
RNAi is proving to be a powerful experimental tool for the functional annotation of mammalian genomes. The full potential of this technology will be realized through development of approaches permitting regulated manipulation of endogenous gene expre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461a91fdf8cee77fac4173bb8207e393
https://resolver.caltech.edu/CaltechAUTHORS:SHIpnas06
https://resolver.caltech.edu/CaltechAUTHORS:SHIpnas06
Autor:
Catherine A. Abbott, David L. Baillie, Manoj Bhasin, Gregory Butler, Sangdun Choi, Jacques Cohen, Brian Fayz, Michelle Green, Igor V. Grigoriev, Tom Hsiang, Peter D. Karp, Dmytro Kevorkov, Stephen A. Krawetz, Markus Krummenacker, Pierre Legendre, Robert Lennie, Diego A. Martinez, Vladimir Makarenkov, R. Ian Menz, Audrius Meškauskas, Xiang Jia Min, Helena Nevalainen, Suzanne M. Paley, Shobha Ranganathan, Melissa R. Pitman, Adrian E. Platts, G.P.S. Raghava, Asaf A. Salamov, Leah A. Santat, Gautam B. Singh, Reginald Storms, Nicholas O'Toole, Brian Tjaden, Adrian Tsang, Anna Tsykin, Dawei Wang, Christopher R. Wilkinson, Claire H. Wilson, Sangdao Wongsai, Bin Yao, Yeisoo Yu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::54b9241a3ec91f2d82dc0ff2c706d115
https://doi.org/10.1016/s1874-5334(06)80002-x
https://doi.org/10.1016/s1874-5334(06)80002-x