Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Leah A, Gates"'
Autor:
Leah A. Gates, Bernardo Sgarbi Reis, Peder J. Lund, Matthew R. Paul, Marylene Leboeuf, Zara Nadeem, Tom S. Carroll, Benjamin A. Garcia, Daniel Mucida, C. David Allis
SUMMARYPosttranslational modifications (PTMs) on histone proteins are a key source of regulation on chromatin through impacting genome organization and important cellular processes, including gene expression. These PTMs often arise from small metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f771098e749840d4690b8e3ee171a8b1
https://doi.org/10.1101/2022.09.29.510184
https://doi.org/10.1101/2022.09.29.510184
Autor:
Peder J. Lund, Leah A. Gates, Marylene Leboeuf, Sarah A. Smith, Lillian Chau, Mariana Lopes, Elliot S. Friedman, Yedidya Saiman, Min Soo Kim, Clarissa A. Shoffler, Christopher Petucci, C. David Allis, Gary D. Wu, Benjamin A. Garcia
Publikováno v:
Cell Rep
The gut microbiota influences acetylation on host histones by fermenting dietary fiber into butyrate. Although butyrate could promote histone acetylation by inhibiting histone deacetylases, it may also undergo oxidation to acetyl-coenzyme A (CoA), a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::219f22054cac3b78bf6a94a30a3e7f6a
https://pubmed.ncbi.nlm.nih.gov/36516747
https://pubmed.ncbi.nlm.nih.gov/36516747
Autor:
Antony J, Burton, Michael, Haugbro, Leah A, Gates, John D, Bagert, C David, Allis, Tom W, Muir
Publikováno v:
Nature chemistry. 12(6)
Elucidating the physiological binding partners of histone post-translational modifications (hPTMs) is key to understanding fundamental epigenetic regulatory pathways. Determining such interactomes will enable the study of how perturbations of these i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d4b7a584e2d5c406c0d9ac57256063c1
https://pubmed.ncbi.nlm.nih.gov/32472102
https://pubmed.ncbi.nlm.nih.gov/32472102
Autor:
Andrew P. Rice, Zheng Zhang, Edward B. Siwak, Bryan C. Nikolai, Sung Yun Jung, Bert W. O'Malley, Qin Feng, Bin He, Leah A. Gates
Publikováno v:
Nucleic Acids Research
In eukaryotic cells, the gene expression status is strictly controlled by epigenetic modifications on chromatin. The repressive status of chromatin largely contributes to HIV latency. Studies have shown that modification of histone H3K27 acts as a ke
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5a3461e0f58346b17d5e770f75f2826
https://doi.org/10.1093/nar/gkx550
https://doi.org/10.1093/nar/gkx550
Autor:
Erin Stashi, Naomi Gonzales, Subhamoy Dasgupta, Bokai Zhu, Bert W. O'Malley, Brian York, Clifford C. Dacso, Leah A. Gates, Adam Dean
Publikováno v:
Molecular Cell. 60(5):769-783
A central mechanism for controlling circadian gene amplitude remains elusive. We present evidence for a “facilitated repression (FR)” model that functions as an amplitude rheostat for circadian gene oscillation. We demonstrate that ROR and/or BMA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9859cd3d23b9651677daaeb88e34f88f
Particular chromatin modifications are associated with different states of gene transcription, yet determining which modifications are causal ‘drivers’ in promoting transcription is incompletely understood. Here, we discuss new developments descr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bae76a3507a3fd3a2f6527e19f0aaa9
https://europepmc.org/articles/PMC5701853/
https://europepmc.org/articles/PMC5701853/
Autor:
Cari A. Sagum, Sung Yun Jung, Leah A. Gates, Ming-Jer Tsai, Bokai Zhu, Bert W. O'Malley, Sophia Y. Tsai, Jiejun Shi, Qin Feng, Mark T. Bedford, Charles E. Foulds, Jun Qin, Aarti D. Rohira, Wei Li
Publikováno v:
The Journal of biological chemistry. 292(35)
The transition from transcription initiation to elongation is a key regulatory step in gene expression, which requires RNA polymerase II (pol II) to escape promoter proximal pausing on chromatin. Although elongation factors promote pause release lead
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05a6b400998044d1fafd687bd53a639
https://pubmed.ncbi.nlm.nih.gov/28717009
https://pubmed.ncbi.nlm.nih.gov/28717009
Autor:
Yue Chen, Jun Qin, Anna Malovannaya, Shu-Ping Wang, Jieya Shao, Antrix Jain, Matthew J. Ellis, Jonathan T. Lei, Aarti D. Rohira, Guowei Gu, Robert G. Roeder, Jiangyong Shao, Charles E. Foulds, Suzanne A. W. Fuqua, Sung Yun Jung, Jin Wang, Shunqiang Li, Philip Lavere, David M. Lonard, David Edwards, Ross A. Hamilton, Yang Yu, Leah A. Gates, Ping Yi, Bert W. O'Malley
Publikováno v:
Oncogene
Approximately 75% of breast cancers are estrogen receptor alpha (ERα)-positive and are treatable with endocrine therapies, but often patients develop lethal resistant disease. Frequent mutations (10-40%) in the ligand-binding domain (LBD) codons in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e82ca89f3a25b8c13043c87d4c0421
https://pubmed.ncbi.nlm.nih.gov/29748621
https://pubmed.ncbi.nlm.nih.gov/29748621
Autor:
Chunshu Li, Jun Qin, Ross A. Hamilton, Sophia Y. Tsai, Zheng Zhang, Ming-Jer Tsai, Suzanna L. Bailey, Dean P. Edwards, Bert W. O'Malley, Doug W. Chan, Leah A. Gates, Amol O. Bajaj, Anna Malovannaya, Qin Feng, Charles E. Foulds, Chen Ding, David M. Lonard, Tamra L. Hunsaker, Celetta Callaway
Publikováno v:
Molecular Cell. 51(2):185-199
Chromatin immunoprecipitation studies have mapped protein occupancies at many genomic loci. However, a detailed picture of the complexity of coregulators (CoRs) bound to a defined enhancer along with a transcription factor is missing. To address this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb087784ae43b359e387e9832491542
Publikováno v:
Drug Metabolism and Disposition. 40:596-601
Furan is a liver toxicant and carcinogen in rodents. It is classified as a possible human carcinogen, but the human health effects of furan exposure remain unknown. The oxidation of furan by cytochrome P450 (P450) enzymes is necessary for furan toxic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5f5984565197e7d963bce70e70ed151
https://doi.org/10.1124/dmd.111.043679
https://doi.org/10.1124/dmd.111.043679