Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Leading edge membrane"'
Autor:
Zhanxiang Wang, Liwei Zhou, Yanxi Shi, Wenpeng Zhao, Bingchang Zhang, Zhengye Jiang, Yuanyuan Xie, Guowei Tan, Yaya Zhang
Publikováno v:
BMC Oral Health, Vol 21, Iss 1, Pp 1-11 (2021)
Background Although chronic periodontitis has previously been reported to be linked with Alzheimer's disease (AD), the pathogenesis between the two is unclear. The purpose of this study is to analyze and screen the relevant and promising molecular ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9950e70533f9d6cf8e8aaea27a7d2beb
https://pubmed.ncbi.nlm.nih.gov/34556089
https://pubmed.ncbi.nlm.nih.gov/34556089
Autor:
Jan Mueller, Mathias Müsken, Martin Falcke, Setareh Dolati, Gunnar Dittmar, Klemens Rottner, Marieluise Kirchner, Michael Sixt, Frieda Kage
Publikováno v:
Molecular Biology of the Cell
Molecular biology of the cell
Molecular biology of the cell
Lamellipodia are flat membrane protrusions formed during mesenchymal motion. Polymerization at the leading edge assembles the actin filament network and generates protrusion force. How this force is supported by the network and how the assembly rate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccfec387c511cc432261c9b4ccc03bc2
http://europepmc.org/articles/PMC6249830
http://europepmc.org/articles/PMC6249830
Publikováno v:
The Journal of Neuroscience. 36:2267-2282
Growth cones interact with the extracellular matrix (ECM) through integrin receptors at adhesion sites termed point contacts. Point contact adhesions link ECM proteins to the actin cytoskeleton through numerous adaptor and signaling proteins. One pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a24bc4362aa0b6e17fcbecfeb30873
https://doi.org/10.1523/jneurosci.2645-15.2016
https://doi.org/10.1523/jneurosci.2645-15.2016
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171905 (2017)
PLoS ONE
PLoS ONE
Matrix Metalloproteinases (Mmps) degrade glycoproteins and proteoglycans of the extracellular matrix (ECM) or cell surface and are crucial for morphogenesis. Mmps and their inhibitors are expressed during early stages of cardiac development in verteb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18354b2c25aabaff545ebbd4a2021bf0
http://europepmc.org/articles/PMC5305246?pdf=render
http://europepmc.org/articles/PMC5305246?pdf=render
Autor:
Joseph J. Falke, Brian P. Ziemba
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0196678 (2018)
PLoS ONE
PLoS ONE
The leukocyte chemosensory pathway detects attractant gradients and directs cell migration to sites of inflammation, infection, tissue damage, and carcinogenesis. Previous studies have revealed that local Ca2+ and PIP3 signals at the leading edge of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1d868d4dfe31120800a1c308bd2210c
https://doi.org/10.1371/journal.pone.0196678
https://doi.org/10.1371/journal.pone.0196678
Publikováno v:
Biological & Pharmaceutical Bulletin. 33:35-39
We previously demonstrated that FGD1, the Cdc42 guanine nucleotide exchange factor (GEF) responsible for faciogenital dysplasia, and its homologue FGD3 are targeted by the ubiquitin ligase SCF(FWD1) upon phosphorylation of two serine residues in thei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49c8e8860b8d0c9c20de41fa1885bd03
https://doi.org/10.1248/bpb.33.35
https://doi.org/10.1248/bpb.33.35
Autor:
Anthony C. Kim, Anwar A. Khan, Anna Huttenlocher, Shafi M. Kuchay, Emily J. Welch, Brendan J. Quinn, Mary A. Lokuta, Athar H. Chishti
Publikováno v:
Proceedings of the National Academy of Sciences. 106:19842-19847
As mediators of innate immunity, neutrophils respond to chemoattractants by adopting a highly polarized morphology. Efficient chemotaxis requires the formation of one prominent pseudopod at the cell front characterized by actin polymerization, while
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bee3109856d5966aa0dbe5d9e98ccabc
https://doi.org/10.1073/pnas.0906761106
https://doi.org/10.1073/pnas.0906761106
Autor:
Yasuo Horie, Hiroshi Watanabe, Yasunori Kanaho, Shoko Kuroda, Shunsuke Takasuga, Ryota Iizuka, Choji Taya, Tak W. Mak, Takehiko Sasaki, Junko Sasaki, Reietsu Itoh, Irmgard Förster, Akira Suzuki, Miki Nishio, Ken Ichi Watanabe, Hiromichi Yonekawa, Tamas Balla, Masakazu Yamazaki, Josef M. Penninger
Publikováno v:
Nature Cell Biology. 9:36-44
Proper neutrophil migration into inflammatory sites ensures host defense without tissue damage. Phosphoinositide 3-kinase (PI(3)K) and its lipid product phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) regulate cell migration, but the role
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b6668d474d24ecce0d590bfeb19b5d9
https://doi.org/10.1038/ncb1515
https://doi.org/10.1038/ncb1515
Publikováno v:
Journal of Biological Chemistry. 275:35384-35392
To migrate in the vessel wall, smooth muscle cells (SMCs) must contend with abundant type I collagen. We investigated the mechanisms used by human SMCs to efficiently migrate on type I collagen, following stimulation with fibroblast growth factor-2 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1532a90bf1e24321fc1d12818a9fe7
https://doi.org/10.1074/jbc.m005139200
https://doi.org/10.1074/jbc.m005139200
Autor:
Zhigang Li, Narendra Thapa, Suyong Choi, David B. Sacks, Andrew C. Hedman, Richard A. Anderson
Phosphatidylinositol 4,5 bisphosphate (PIP2) is a key lipid messenger for regulation of cell migration. PIP2 modulates many effectors, but the specificity of PIP2 signalling can be defined by interactions of PIP2-generating enzymes with PIP2 effector
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef2178df5f3a7e37df24f865a61abdf4
https://europepmc.org/articles/PMC3791370/
https://europepmc.org/articles/PMC3791370/
