Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Lea-Ann S Kirkham"'
Autor:
Ruth B Thornton, Lea-Ann S Kirkham
Publikováno v:
Microbiology Australia, Vol 42, Iss 2, Pp 75-78 (2021)
Otitis media (OM; middle ear infection) is the most common reason for pre-school children to visit a doctor, be prescribed antimicrobials, or undergo surgery. Recent Cochrane reviews of clinical trials have identified that antibiotics and gromme
Externí odkaz:
https://doaj.org/article/f82b3a49f6b84a048f56b8b3015413c9
Autor:
Elke J Seppanen, Ruth B Thornton, Karli J Corscadden, Caitlyn M Granland, Julie Hibbert, Angela Fuery, Selma P Wiertsema, Shyan Vijayasekaran, Harvey L Coates, Peter Jacoby, Andrew Currie, Peter C Richmond, Lea-Ann S Kirkham
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0227080 (2019)
Recurrent and chronic otitis media (OM) are often refractory to antibiotics due to bacterial persistence in biofilm within the middle ear. In vitro and in vivo studies have demonstrated that antimicrobial proteins and peptides (AMPs) are bactericidal
Externí odkaz:
https://doaj.org/article/7584fa9e659047ddacefbfa91adbf024
Autor:
Elke Seppanen, Dino Tan, Karli J Corscadden, Andrew J Currie, Peter C Richmond, Ruth B Thornton, Lea-Ann S Kirkham
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0193962 (2018)
Otitis media (OM) remains a common paediatric disease, despite advances in vaccinology. Susceptibility to recurrent acute OM (rAOM) has been postulated to involve defective cell-mediated immune responses to common otopathogenic bacteria. We compared
Externí odkaz:
https://doaj.org/article/a7f923c2e81c48e785563c0713b89e51
Autor:
Laila N Abudulai, Sonia Fernandez, Karli Corscadden, Sally A Burrows, Michael Hunter, M Christian Tjiam, Lea-Ann S Kirkham, Jeffrey J Post, Martyn A French
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0176641 (2017)
Dysfunction of T follicular-helper (TFH) cells is a possible cause of impaired germinal centre (GC) and IgG antibody responses in individuals with human immunodeficiency virus-1 (HIV-1) infection and might contribute to decreased magnitude and isotyp
Externí odkaz:
https://doaj.org/article/a91e74ee77684e81b9f7fec1a94d0cb3
Autor:
Janessa Lea Pickering, Amy eProsser, Karli eCorscadden, Camilla ede Gier, Peter C Richmond, Guicheng eZhang, Ruth eThornton, Lea-Ann S Kirkham
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)
Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that resides in the upper respiratory tract and contributes to a significant burden of respiratory related diseases in children and adults. Haemophilus haemolyticus is a respirato
Externí odkaz:
https://doaj.org/article/6985bbacb3a7439b91bcab2fd5cc2066
Publikováno v:
Frontiers in Microbiology, Vol 5 (2014)
Nontypeable Haemophilus influenzae (NTHi) and Haemophilus haemolyticus are closely related bacteria that reside in the upper respiratory tract. NTHi is associated with respiratory tract infections that frequently result in antibiotic prescription whi
Externí odkaz:
https://doaj.org/article/bb73de5dfca148b4af9507e739238184
Autor:
Ruth B Thornton, Selma P Wiertsema, Lea-Ann S Kirkham, Paul J Rigby, Shyan Vijayasekaran, Harvey L Coates, Peter C Richmond
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e53837 (2013)
BACKGROUND: Bacteria persist within biofilms on the middle ear mucosa of children with recurrent and chronic otitis media however the mechanisms by which these develop remain to be elucidated. Biopsies can be difficult to obtain from children and the
Externí odkaz:
https://doaj.org/article/118fb187ad534f0fa727a94b88a757fb
Autor:
Selma P Wiertsema, Karli J Corscadden, Eva N Mowe, Guicheng Zhang, Shyan Vijayasekaran, Harvey L Coates, Timothy J Mitchell, Wayne R Thomas, Peter C Richmond, Lea-Ann S Kirkham
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49061 (2012)
BackgroundVaccines including conserved antigens from Streptococcus pneumoniae and nontypeable Haemophilus influenzae (NTHi) have the potential to reduce the burden of acute otitis media. Little is known about the antibody response to such antigens in
Externí odkaz:
https://doaj.org/article/49c3e2c5c7c64f2384f656f5c7a1bede
Autor:
Kelly M. Martinovich, Elke J. Seppanen, Amy S. Bleakley, Sharon L. Clark, Ross M. Andrews, Peter C. Richmond, Michael J. Binks, Ruth B. Thornton, Lea-Ann S. Kirkham
Publikováno v:
Frontiers in Immunology. 13
IntroductionChildren in low-mid income countries, and First Nations children in high-income countries, experience disproportionately high rates of Streptococcus pneumoniae and Haemophilus influenzae infections and diseases including pneumonia and oti
Autor:
Rebecca Ford, Elke J. Seppanen, Camilla de Gier, Jacinta Francis, Tilda Orami, Karli J. Corscadden, William Pomat, Audrey Michael, Mition Yoannes, Lea Ann S. Kirkham, Caitlyn Granland, Peter Jacoby, Ruth B. Thornton, Tasmina Rahman, Deborah Lehmann, K. Martinovich, Anita H. J. van den Biggelaar, Peter Richmond
Publikováno v:
Vaccine. 39:3486-3492
Background Nasopharyngeal colonisation with nontypeable Haemophilus influenzae (NTHi) is associated with development of infections including pneumonia and otitis media. The 10-valent pneumococcal conjugate vaccine (PCV10) uses NTHi Protein D (PD) as