Orexin induces the production of an endocannabinoid-derived lysophosphatidic acid eliciting hypothalamic synaptic loss in obesity

Autor: Alba Clara Fernández-Rilo, Nicola Forte, Letizia Palomba, Lea Tunisi, Fabiana Piscitelli, Roberta Imperatore, Alfonso Di Costanzo, Vincenzo Di Marzo, Luigia Cristino

Publikováno v: Molecular Metabolism, Vol 72, Iss , Pp 101713- (2023)

Objective: Orexin-A (OX-A) is a neuropeptide produced selectively by neurons of the lateral hypothalamus. It exerts powerful control over brain function and physiology by regulating energy homeostasis and complex behaviors linked to arousal. Under co

Externí odkaz: https://doaj.org/article/9264eccabc294d96960ef6595ab4fb4d

Altered heparan sulfate metabolism during development triggers dopamine-dependent autistic-behaviours in models of lysosomal storage disorders

Autor: Maria De Risi, Michele Tufano, Filomena Grazia Alvino, Maria Grazia Ferraro, Giulia Torromino, Ylenia Gigante, Jlenia Monfregola, Elena Marrocco, Salvatore Pulcrano, Lea Tunisi, Claudia Lubrano, Dulce Papy-Garcia, Yaakov Tuchman, Alberto Salleo, Francesca Santoro, Gian Carlo Bellenchi, Luigia Cristino, Andrea Ballabio, Alessandro Fraldi, Elvira De Leonibus

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Lysosomal storage disorders, characterized by altered metabolism of heparan sulfate, cause autistic symptoms followed by dementia in children. Here, the authors show that embryonic dopaminergic neurodevelopmental defects due to altered function of he

Externí odkaz: https://doaj.org/article/5ebeb3f36eeb489b8e165e8571b181e3

Orexin-A/Hypocretin-1 Controls the VTA-NAc Mesolimbic Pathway via Endocannabinoid-Mediated Disinhibition of Dopaminergic Neurons in Obese Mice

Autor: Lea Tunisi, Livia D'Angelo, Alba Clara Fernández-Rilo, Nicola Forte, Fabiana Piscitelli, Roberta Imperatore, Paolo de Girolamo, Vincenzo Di Marzo, Luigia Cristino

Publikováno v: Frontiers in Synaptic Neuroscience, Vol 13 (2021)

Disinhibition of orexin-A/hypocretin-1 (OX-A) release occurs to several output areas of the lateral hypothalamus (LH) in the brain of leptin knockout obese ob/ob mice. In this study, we have investigated whether a similar increase of OX-A release occ

Externí odkaz: https://doaj.org/article/c47bf340562d4fb7bb17264200e6b608

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier

Autor: Lea Tunisi, Nicola Forte, Alba Clara Fernández-Rilo, Isabella Mavaro, Raffaele Capasso, Livia D'Angelo, Nataša Milić, Luigia Cristino, Vincenzo Di Marzo, Letizia Palomba

Publikováno v: Frontiers in Endocrinology, Vol 10 (2019)

In states of intestinal dysbiosis, a perturbation of the normal microbiome composition, the intestinal epithelial barrier (IEB) permeability is increased as a result of the disruption of the epithelial tight junction protein network, in which occludi

Externí odkaz: https://doaj.org/article/5dd65ceae5a24bee94b2163ae0eb07da

Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice

Autor: Fabio Arturo Iannotti, Roberta Imperatore, Luigia Cristino, Serena Boccella, Raffaele Capasso, Fabiana Piscitelli, Monica Iannotta, Maria De Risi, Elvira De Leonibus, Vincenzo Di Marzo, Paolo de Girolamo, Nicola Forte, Sabatino Maione, Lea Tunisi, Alba Clara Fernández-Rilo

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature communications 12 (2021). doi:10.1038/s41467-021-26388-4
info:cnr-pdr/source/autori:Forte N.; Boccella S.; Tunisi L.; Fernandez-Rilo A.C.; Imperatore R.; Iannotti F.A.; De Risi M.; Iannotta M.; Piscitelli F.; Capasso R.; De Girolamo P.; De Leonibus E.; Maione S.; Di Marzo V.; Cristino L./titolo:Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice/doi:10.1038%2Fs41467-021-26388-4/rivista:Nature communications/anno:2021/pagina_da:/pagina_a:/intervallo_pagine:/volume:12
Nature Communications

The mammalian brain stores and distinguishes among episodic memories, i.e. memories formed during the personal experience, through a mechanism of pattern separation computed in the hippocampal dentate gyrus. Decision-making for food-related behaviors

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a24d23cc7a5a38d30f7916ae7e129b
https://doaj.org/article/cc36a8296dcb45b6b3ee6a982be5d94e