Zobrazeno 1 - 10
of 470
pro vyhledávání: '"Lea T. Grinberg"'
Autor:
Breton M. Asken, Jessica M. Bove, Russell M. Bauer, Jeremy A. Tanner, Kaitlin B. Casaletto, Adam M. Staffaroni, Lawren VandeVrede, Michael L. Alosco, Jesse B. Mez, Robert A. Stern, Bruce L. Miller, Lea T. Grinberg, Adam L. Boxer, Maria Luisa Gorno-Tempini, Howie J. Rosen, Gil D. Rabinovici, Joel H. Kramer
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-10 (2024)
Abstract Background Traumatic brain injury (TBI) and repetitive head impacts (RHI) have been linked to increased risk for multiple types of neurodegenerative disease, higher dementia risk, and earlier age of dementia symptom onset, suggesting transdi
Externí odkaz:
https://doaj.org/article/e6317e81cad640f78dcc0f579d63519a
Autor:
Roberta Diehl Rodriguez, Maria Clotilde H. Tavares, Sonia Maria Dozzi Brucki, Leonel Tadao Takada, Maria Concepción Garcia Otaduy, Maria da Graça Morais Martin, Claudia Kimie Suemoto, Lea T. Grinberg, Claudia Costa Leite, Carlos Tomaz, Ricardo Nitrini
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024)
Abstract The absence of a natural animal model is one of the main challenges in Alzheimer’s disease research. Despite the challenges of using nonhuman primates in studies, these animals can bridge mouse models and humans, as nonhuman primates are p
Externí odkaz:
https://doaj.org/article/533267f262a14e1384b1c52ff185a885
Autor:
Elisa dePaula França Resende, Vivian P. Lara, Ana Luisa C. Santiago, Clarisse V. Friedlaender, Howard J. Rosen, Jesse A. Brown, Yann Cobigo, Lênio L. G. Silva, Leonardo Cruz de Souza, Luciana Rincon, Lea T. Grinberg, Francisca I. P. Maciel, Paulo Caramelli
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 3, Pp n/a-n/a (2024)
Abstract INTRODUCTION The influence of hippocampal connectivity on memory performance is well established in individuals with high educational attainment. However, the role of hippocampal connectivity in illiterate populations remains poorly understo
Externí odkaz:
https://doaj.org/article/00ef29b25e9c425090fdc4aa429530c5
Autor:
Liara Rizzi, Lea T. Grinberg
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-3 (2024)
Externí odkaz:
https://doaj.org/article/2a900efc23e841ac93703c2e70119f97
Autor:
Liara Rizzi, Lea T. Grinberg
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-10 (2024)
Abstract Tauopathies are neurodegenerative diseases that typically require postmortem examination for a definitive diagnosis. Detecting neurotoxic tau fragments in cerebrospinal fluid (CSF) and serum provides an opportunity for in vivo diagnosis and
Externí odkaz:
https://doaj.org/article/7c9797065fd1442782ee2fde6b5968c3
Autor:
Niyatee Samudra, Hannah Lerner, Leslie Yack, Christine M. Walsh, Heidi E. Kirsch, Kiwamu Kudo, Claire Yballa, Renaud La Joie, Maria L. Gorno‐Tempini, Salvatore Spina, William W. Seeley, Thomas C. Neylan, Bruce L. Miller, Gil D. Rabinovici, Adam Boxer, Lea T. Grinberg, Katherine P. Rankin, Srikantan S. Nagarajan, Kamalini G. Ranasinghe
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 11, Iss 2, Pp 525-535 (2024)
Abstract Introduction Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), are the most common four‐repeat tauopathies (4RT), and both frequently occur with varying degree of Alzheimer's disease (AD) copathology. Intriguingly,
Externí odkaz:
https://doaj.org/article/c6a7c6da131a41e9a2a910656dc41c1d
Publikováno v:
Molecular Neurodegeneration, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract Tauopathies, a group of neurodegenerative diseases that includes Alzheimer’s disease, commonly lead to disturbances in sleep-wake patterns and circadian rhythm disorders. The circadian rhythm, a recurring 24-hour cycle governing human biol
Externí odkaz:
https://doaj.org/article/91ce5dfb631f4ae0abcfaeb419245f26
Autor:
Regina Silva Paradela, Alberto Fernando Oliveira Justo, Vítor Ribeiro Paes, Renata E. P. Leite, Carlos A. Pasqualucci, Lea T. Grinberg, Michel Satya Naslavsky, Mayana Zatz, Ricardo Nitrini, Wilson Jacob-Filho, Claudia Kimie Suemoto
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-10 (2023)
Abstract Background Apolipoprotein E ε4 allele (APOE-ε4) is the main genetic risk factor for late-onset Alzheimer’s disease (AD) and may impact cognitive function also via other neuropathological lesions. However, there is limited evidence availa
Externí odkaz:
https://doaj.org/article/1cb2435c440542a187c72e5b2f821d40
Publikováno v:
Frontiers in Aging Neuroscience, Vol 16 (2024)
This manuscript presents a thorough review of synaptic vesicle glycoprotein 2A (SV2A) as a biomarker for synaptic integrity using Positron Emission Tomography (PET) in neurodegenerative diseases. Synaptic pathology, characterized by synaptic loss, ha
Externí odkaz:
https://doaj.org/article/aaeaf0c5f0c144129e45ee93aaf1d7d7
Autor:
Felipe C. Ribeiro, Danielle Cozachenco, Luana Heimfarth, Juliana T. S. Fortuna, Guilherme B. de Freitas, Jorge M. de Sousa, Soniza V. Alves-Leon, Renata E. P. Leite, Claudia K. Suemoto, Lea T. Grinberg, Fernanda G. De Felice, Mychael V. Lourenco, Sergio T. Ferreira
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-12 (2023)
Abstract The proteasome plays key roles in synaptic plasticity and memory by regulating protein turnover, quality control, and elimination of oxidized/misfolded proteins. Here, we investigate proteasome function and localization at synapses in Alzhei
Externí odkaz:
https://doaj.org/article/bdf4804051b140dd9c552fb96120595a