Zobrazeno 1 - 10
of 469
pro vyhledávání: '"Lea T Grinberg"'
Autor:
Simone Steinbach, Mariana Molina, Lea T Grinberg, Luisa Aring, Annika Guntermann, Katrin Marcus, Helmut Heinsen, Renata E Paraizo Leite, Caroline May
Publikováno v:
PLoS ONE, Vol 19, Iss 7, p e0296730 (2024)
A hallmark of Parkinson's disease is the specific degeneration of dopaminergic neurons in the substantia nigra pars compacta. Interestingly, not all of these neurons are affected to the same extent. Studies revealed that neurons located more ventrall
Externí odkaz:
https://doaj.org/article/c8e5c7a6e8da40168abe375de7542998
Autor:
Neus Falgàs, Ignacio Illán-Gala, Isabel E Allen, Paige Mumford, Youssef M Essanaa, Michael M Le, Michelle You, Lea T Grinberg, Howard J Rosen, Thomas C Neylan, Joel H Kramer, Christine M Walsh
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252076 (2021)
BackgroundThere is an increasing awareness that sleep disturbances are a risk factor for dementia. Prior case-control studies suggested that brain grey matter (GM) changes involving cortical (i.e, prefrontal areas) and subcortical structures (i.e, pu
Externí odkaz:
https://doaj.org/article/b545756540414093bfb085c17e637163
Autor:
Claudia K Suemoto, Renata E L Ferretti-Rebustini, Roberta D Rodriguez, Renata E P Leite, Luciana Soterio, Sonia M D Brucki, Raphael R Spera, Tarcila M Cippiciani, Jose M Farfel, Alexandre Chiavegatto Filho, Michel Satya Naslavsky, Mayana Zatz, Carlos A Pasqualucci, Wilson Jacob-Filho, Ricardo Nitrini, Lea T Grinberg
Publikováno v:
PLoS Medicine, Vol 14, Iss 3, p e1002267 (2017)
BACKGROUND:Clinicopathological studies are important in determining the brain lesions underlying dementia. Although almost 60% of individuals with dementia live in developing countries, few clinicopathological studies focus on these individuals. We i
Externí odkaz:
https://doaj.org/article/b96735f0fc084b65a9266e154e837810
Autor:
Aline Nishizawa, Claudia K Suemoto, Daniela S Farias-Itao, Fernanda M Campos, Karen C S Silva, Marcio S Bittencourt, Lea T Grinberg, Renata E P Leite, Renata E L Ferretti-Rebustini, Jose M Farfel, Wilson Jacob-Filho, Carlos A Pasqualucci
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0186630 (2017)
BACKGROUND:Morphometric measurements of systemic atherosclerosis and direct quantification of visceral fat are only possible using materials from autopsy studies. However, the few autopsy studies that have investigated the association of visceral fat
Externí odkaz:
https://doaj.org/article/70c8eecd75144dc5b850c12d8393a049
Autor:
Aderbal R T Silva, Ana Cecília Feio Santos, Jose M Farfel, Lea T Grinberg, Renata E L Ferretti, Antonio Hugo Jose Froes Marques Campos, Isabela Werneck Cunha, Maria Dirlei Begnami, Rafael M Rocha, Dirce M Carraro, Carlos Alberto de Bragança Pereira, Wilson Jacob-Filho, Helena Brentani
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e99897 (2014)
Alzheimer's disease (AD) is characterized by progressive cognitive decline associated with a featured neuropathology (neuritic plaques and neurofibrillary tangles). Several studies have implicated oxidative damage to DNA, DNA repair, and altered cell
Externí odkaz:
https://doaj.org/article/92b7d31145934878aa0b76bb07b1b384
Sexual dimorphism in the human olfactory bulb: females have more neurons and glial cells than males.
Autor:
Ana V Oliveira-Pinto, Raquel M Santos, Renan A Coutinho, Lays M Oliveira, Gláucia B Santos, Ana T L Alho, Renata E P Leite, José M Farfel, Claudia K Suemoto, Lea T Grinberg, Carlos A Pasqualucci, Wilson Jacob-Filho, Roberto Lent
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111733 (2014)
Sex differences in the human olfactory function reportedly exist for olfactory sensitivity, odorant identification and memory, and tasks in which odors are rated based on psychological features such as familiarity, intensity, pleasantness, and others
Externí odkaz:
https://doaj.org/article/8a742b16f8a64da6b9b2171ef8209c4d
Autor:
Aderbal R T Silva, Lea T Grinberg, Jose M Farfel, Breno S Diniz, Leandro A Lima, Paulo J S Silva, Renata E L Ferretti, Rafael M Rocha, Wilson Jacob Filho, Dirce M Carraro, Helena Brentani
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e48751 (2012)
Alzheimer's disease (AD) is the most common cause of dementia in the human population, characterized by a spectrum of neuropathological abnormalities that results in memory impairment and loss of other cognitive processes as well as the presence of n
Externí odkaz:
https://doaj.org/article/61d78bb5975541b1afb23b261a52861e
Publikováno v:
Frontiers in Neurology, Vol 2 (2011)
The most frequent neurodegenerative diseases (NDs) are Alzheimer’s disease (AD), Parkinson’s disease (PD), and frontotemporal lobar degeneration associated with protein TDP-43 (FTLD-TDP). Neuropathologically, NDs are characterized by abnormal int
Externí odkaz:
https://doaj.org/article/7cc27d4f1e384036a8596f73553b5039
Autor:
Skylar E. Davis, Anna K. Cook, Justin A. Hall, Yuliya Voskobiynyk, Nancy V. Carullo, Nicholas R. Boyle, Ahmad R. Hakim, Kristian M. Anderson, Kierra P. Hobdy, Derian A. Pugh, Charles F. Murchison, Laura J. McMeekin, Micah Simmons, Katherine A. Margolies, Rita M. Cowell, Alissa L. Nana, Salvatore Spina, Lea T. Grinberg, Bruce L. Miller, William W. Seeley, Andrew E. Arrant
Publikováno v:
Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-19 (2023)
Abstract Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) develop frontotemporal lobar degeneration with TDP-43 pathology type A (FTLD
Externí odkaz:
https://doaj.org/article/cb7d9e8149f4472c81b6d7612826356c
Autor:
Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, Pedro C. Malia, Ruth C. Richards, Alexander W. Fischer, Shubham Singh, Geetika Aggarwal, Salvatore Spina, Alissa L. Nana, Lea T. Grinberg, William W. Seeley, Michal A. Surma, Christian Klose, Joao A. Paulo, Andrew D. Nguyen, J. Wade Harper, Tobias C. Walther, Robert V. Farese
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Progranulin-deficieny results in gangliosidosis due to reduced lysosomal lipids (BMP) required for ganglioside degradation. Lysosomal ganglioside accumulation may contribute to neuroinflammation and neurodegeneration susceptibility observed in FTD.
Externí odkaz:
https://doaj.org/article/1474593e97d94a4ab73bc2bde059f30e