Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study

Autor: Lea S Blaser, Urs Duthaler, Jamal Bouitbir, Anne B Leuppi-Taegtmeyer, Evangelia Liakoni, Reto Dolf, Michael Mayr, Jürgen Drewe, Stephan Krähenbühl, Manuel Haschke

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic ef

Externí odkaz: https://doaj.org/article/90f5c5c6045e47539c09d00108323638

Leucopenia associated with metamizole: a case-control study

Autor: Lea S. Blaser, Alexandra E. Rätz Bravo, Sarah Hofmann, Andreas Holbro, Manuel Haschke, Stephan Krähenbühl, Hala Hassna, Anne B. Taegtmeyer, Andreas Zeller

Publikováno v: Blaser, Lea; Hassna, Hala; Hofmann, Sarah; Holbro, Andreas; Haschke, Manuel Martin; Rätz Bravo, Alexandra; Zeller, Andreas; Krähenbühl, Stephan; Taegtmeyer, Anne (2017). Leucopenia associated with metamizole: a case-control study. Swiss medical weekly, 147, w14438. EMH Schweizerischer Ärzteverlag 10.4414/smw.2017.14438

AIMS OF THE STUDY The aim of this study was to identify possible risk factors for the development of leucopenia associated with metamizole use. METHODS A retrospective case-control study was performed. Cases of metamizole-associated leucopenia manage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::904b6173672584f7f87b54c6f85efd62
https://pubmed.ncbi.nlm.nih.gov/33378544

Fatale Agranulozytose nach Metamizol-Reexposition

Autor: Evmarie Zeiner, Lea S. Blaser, Anne B. Taegtmeyer, Kai Tisljar, Dominik Heim

Publikováno v: Praxis. 104:151-154

We present the case of a 63 year old man who died of severe septic shock in the setting of agranulocytosis induced by dipyrone (metamizole). The patient had previously developed agranulocytosis after dipyrone exposure 18 months prior to this. The cas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0298be2474545b6a2238dc4ee0b6b139
https://doi.org/10.1024/1661-8157/a001916

Hematological safety of metamizole: retrospective analysis of WHO and Swiss spontaneous safety reports

Autor: Manuel Haschke, Lea S. Blaser, Alexandra Tramonti, Pascal Egger, Stephan Krähenbühl, Alexandra E. Rätz Bravo

Publikováno v: European journal of clinical pharmacology. 71(2)

Purpose: Since the 1970s, the use of metamizole is controversial due to the risk of agranulocytosis. The aim of this study was to analyze individual case safety reports (ICSRs) of metamizole-associated hematological adverse drug reactions (ADRs). Met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457ae4c412d6878229149ff9cb92841f
https://pubmed.ncbi.nlm.nih.gov/25401171

Glucose-Induced Glucagon-Like Peptide 1 Secretion Is Deficient in Patients with Non-Alcoholic Fatty Liver Disease.

Autor: Bernsmeier, Christine^1,2 c.bernsmeier@unibas.ch, Meyer-Gerspach, Anne C.², Blaser, Lea S.², Jeker, Lia², Steinert, Robert E.², Heim, Markus H.^1,2, Beglinger, Christoph^1,2

Publikováno v: PLoS ONE. Jan2014, Vol. 9 Issue 1, p1-7. 7p.