Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lea Rodriguez"'
Autor:
Maud Gratuze, Johannes C.M. Schlachetzki, Ricardo D’Oliveira Albanus, Nimansha Jain, Brenna Novotny, Logan Brase, Lea Rodriguez, Clayton Mansel, Michal Kipnis, Sydney O’Brien, Martina P. Pasillas, Choonghee Lee, Melissa Manis, Marco Colonna, Oscar Harari, Christopher K. Glass, Jason D. Ulrich, David M. Holtzman
Publikováno v:
Neuron.
In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimer's disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau-linked neurodegeneration and inflammation in P301S tau mice and removal of mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0d57607351440cd9045f9dd6e14bd0
https://pubmed.ncbi.nlm.nih.gov/36368315
https://pubmed.ncbi.nlm.nih.gov/36368315
Autor:
Sandrine Joly, Julius Baya Mdzomba, Léa Rodriguez, Françoise Morin, Luc Vallières, Vincent Pernet
Publikováno v:
Journal of Neuroinflammation, Vol 19, Iss 1, Pp 1-17 (2022)
Abstract Background In the field of autoimmune demyelinating diseases, visual impairments have extensively been studied using the experimental autoimmune encephalomyelitis (EAE) mouse model, which is classically induced by immunization with myelin ol
Externí odkaz:
https://doaj.org/article/c7c30ba28d814c0f9ca09d39bc3e4a39
Autor:
Christian Lévêque, Yves Maulet, Qili Wang, Marion Rame, Léa Rodriguez, Sumiko Mochida, Marion Sangiardi, Fahamoe Youssouf, Cécile Iborra, Michael Seagar, Nicolas Vitale, Oussama El Far
Publikováno v:
Cells, Vol 12, Iss 5, p 750 (2023)
V-ATPase is an important factor in synaptic vesicle acidification and is implicated in synaptic transmission. Rotation in the extra-membranous V1 sector drives proton transfer through the membrane-embedded multi-subunit V0 sector of the V-ATPase. Int
Externí odkaz:
https://doaj.org/article/59f893d975e14efca870c5732bb32957
Autor:
Essi F. Biyong, Cyntia Tremblay, Manon Leclerc, Vicky Caron, Serge Alfos, Jean-Christophe Helbling, Léa Rodriguez, Vincent Pernet, David A. Bennett, Véronique Pallet, Frédéric Calon
Publikováno v:
Neurobiology of Disease, Vol 161, Iss , Pp 105542- (2021)
Background: Vitamin A (VitA), via its active metabolite retinoic acid (RA), is critical for the maintenance of memory function with advancing age. Although its role in Alzheimer's disease (AD) is not well understood, data suggest that impaired brain
Externí odkaz:
https://doaj.org/article/f5fc3723625a42ecb80950e796769d61
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11344 (2021)
We have previously reported that vision decline was not associated with amyloidogenesis processing in aging C57BL/6J wild-type (WT) mice and in a mouse model of Alzheimer’s disease, the APPswe/PS1ΔE9 transgenic mouse model (APP/PS1). This conclusi
Externí odkaz:
https://doaj.org/article/8e2a9e0d210e44d0999d02d360bdb43f
Autor:
Assou El-Battari, Léa Rodriguez, Henri Chahinian, Olivier Delézay, Jacques Fantini, Nouara Yahi, Coralie Di Scala
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 21, p 11550 (2021)
We present here a gene therapy approach aimed at preventing the formation of Ca2+-permeable amyloid pore oligomers that are considered as the most neurotoxic structures in both Alzheimer’s and Parkinson’s diseases. Our study is based on the desig
Externí odkaz:
https://doaj.org/article/cfcd4cf4f97b44cfbbb6ba7ca40c603c
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 11, p 4100 (2020)
In the present study, we hypothesized that the microtubule-associated protein Tau may influence retinal neuron survival and axonal regeneration after optic nerve injury. To test this hypothesis, the density of retinal ganglion cells was evaluated by
Externí odkaz:
https://doaj.org/article/3000133d43c2474dbd2f002902c47eb5
Autor:
Léa Rodriguez, Julius Baya Mdzomba, Sandrine Joly, Mélissa Boudreau-Laprise, Emmanuel Planel, Vincent Pernet
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
Externí odkaz:
https://doaj.org/article/30639754907c48ef8933e3389a7bab06
Autor:
Léa Rodriguez, Julius Baya Mdzomba, Sandrine Joly, Mélissa Boudreau-Laprise, Emmanuel Planel, Vincent Pernet
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 11 (2018)
The implication of the microtubule-associated protein (MAP) Tau in the ocular manifestations of Alzheimer’s disease (AD) is elusive due to the lack of relevant animal model. However, signs of AD have been reported in the brain of transgenic mice ex
Externí odkaz:
https://doaj.org/article/ed190b71a4c0458f9ac44eea44175172