Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lea R. Gamez-Jimenez"'
Autor:
Shyam H. Kamble, Samuel Obeng, Francisco León, Luis F. Restrepo, Tamara I. King, Erin C. Berthold, Siva Rama Raju Kanumuri, Lea R. Gamez-Jimenez, Victoria L.C. Pallares, Avi Patel, Nicholas P. Ho, Aidan Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Abhisheak Sharma, Takato Hiranita
Publikováno v:
J Pharmacol Exp Ther
Mitragynine, an opioidergic alkaloid present in Mitragyna speciosa (kratom), is metabolized by cytochrome P450 3A (CYP3A) to 7-hydroxymitragynine, a more potent opioid receptor agonist. The extent to which conversion to 7-hydroxymitragynine mediates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9288dd2b6b7ca7f4d59c89456a88b52
https://doi.org/10.1124/jpet.122.001525
https://doi.org/10.1124/jpet.122.001525
Autor:
Samuel Obeng, Francisco Leon, Avi Patel, Julio D. Zuarth Gonzalez, Lucas Chaves Da Silva, Luis F. Restrepo, Lea R. Gamez-Jimenez, Nicholas P. Ho, Maria P. Guerrero Calvache, Victoria L.C. Pallares, Justin A. Helmes, Sakura K. Shiomitsu, Paul L. Soto, Aidan J. Hampson, Christopher R. McCurdy, Lance R. McMahon, Jenny L. Wilkerson, Takato Hiranita
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 383:182-198
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec28c628ae343e8d881cf992b62e1d4d
https://doi.org/10.1124/jpet.122.001192
https://doi.org/10.1124/jpet.122.001192
Autor:
Victoria L.C. Pallares, Anna E. Pennington, Morgan L. Crowley, Avi Patel, Morgan E. Reeves, Carolina Lopera-Londoño, Marco Mottinelli, Nicholas P. Ho, Francisco León, John D. Fortner, Christopher R. McCurdy, Luis F. Restrepo, Victoria A. Taylor, Jenny L. Wilkerson, Lance R. McMahon, Samuel Obeng, Takato Hiranita, Tobias Braun, Lea R. Gamez-Jimenez, Morgan R. Williamson
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 376:410-427
Relationships between µ-opioid receptor (MOR) efficacy and effects of mitragynine and 7-hydroxymitragynine are not fully established. We assessed in vitro binding affinity and efficacy and discriminative stimulus effects together with antinociceptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72dcbea9c746af3f998d852e8075016a
https://doi.org/10.1124/jpet.120.000189
https://doi.org/10.1124/jpet.120.000189
Autor:
Takato Hiranita, Julio Zuarth Gonzalez, Rohan C. Patel, Christian C. Mazpule‐Carrigan, Joelma Martins Rocha, Lea R. Gamez Jimenez, Nicholas P. Ho, Avi Patel, Samuel Obeng, Francisco Leon, Marco Mottinelli, Sushobhan Mukhopadhyay, Christopher R. McCurdy, Lance R. McMahon
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5ae87d0e1be099e646080afc7b9d48b4
https://doi.org/10.1096/fasebj.2022.36.s1.r5776
https://doi.org/10.1096/fasebj.2022.36.s1.r5776
Autor:
Samuel, Obeng, Francisco, Leon, Avi, Patel, Julio D, Zuarth Gonzalez, Lucas, Chaves Da Silva, Luis F, Restrepo, Lea R, Gamez-Jimenez, Nicholas P, Ho, Maria P, Guerrero Calvache, Victoria L C, Pallares, Justin A, Helmes, Sakura K, Shiomitsu, Paul L, Soto, Christopher R, McCurdy, Lance R, McMahon, Jenny L, Wilkerson, Takato, Hiranita
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 383(3)
The primary kratom alkaloid mitragynine is proposed to act through multiple mechanisms, including actions at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7b558ac58152dc2515d30e4a6142783b
https://pubmed.ncbi.nlm.nih.gov/36153006
https://pubmed.ncbi.nlm.nih.gov/36153006
Autor:
Maria P Guerrero Calvache, Samuel Obeng, Francisco Leon, Lea R Gamez‐Jimenez, Avi Patel, Nicholas P Ho, Morgan L Crowley, Victoria Pallares, Marco Mottinelli, Christopher R McCurdy, Lance R McMahon, Takato Hiranita
Publikováno v:
Alzheimer's & Dementia. 17
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::390aebfcf060b386f09e746b7736a6e7
https://doi.org/10.1002/alz.058605
https://doi.org/10.1002/alz.058605
Autor:
Luis F. Restrepo, Erin C. Berthold, Aidan J. Hampson, Avi Patel, Lance R. McMahon, Carolina Lopera-Londoño, Takato Hiranita, Shyam H. Kamble, Samuel Obeng, Abhisheak Sharma, Lea R. Gamez-Jimenez, Francisco León, Clinton E. Canal, Marco Mottinelli, Christopher R. McCurdy, Yiming Chen, Tamara I. King
Publikováno v:
J Med Chem
Kratom alkaloids have mostly been evaluated for their opioid activity but less at other targets that could contribute to their physiological effects. Here, we investigated the in vitro and in vivo activity of kratom alkaloids at serotonin receptors (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749b326c3ebef7e4aed6ae82cdd6614a
https://europepmc.org/articles/PMC9235362/
https://europepmc.org/articles/PMC9235362/
Autor:
Lea R. Gamez-Jimenez, Lance R. McMahon, Nicholas P. Ho, Julio Zuarth Gonzalez, Victoria L.C. Pallares, Amsha Thadisetti, Marco Mottinelli, Christopher R. McCurdy, Morgan L. Crowley, Manuel G. Alvarez, Takato Hiranita, Samuel Obeng, Avi Patel, Elizabeth Kern, Luis F. Restrepo, Francisco León
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::358fc074f3825a1340a45b4616d8f57b
https://doi.org/10.1096/fasebj.2021.35.s1.05475
https://doi.org/10.1096/fasebj.2021.35.s1.05475
Autor:
Carolina Lopera-Londoño, Lea R. Gamez-Jimenez, Lance R. McMahon, Takato Hiranita, Victoria L.C. Pallares, Julio Zuarth Gonzalez, Avi Patel, Francisco León, Marco Mottinelli, Christopher R. McCurdy, Luis F. Restrepo, Samuel Obeng
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0e9adf59f8c83acd683cc258da1e13b
https://doi.org/10.1096/fasebj.2021.35.s1.04764
https://doi.org/10.1096/fasebj.2021.35.s1.04764
Autor:
Takato Hiranita, Julio Zuarth Gonzalez, Francisco León, Lance R. McMahon, Avi Patel, Marco Mottinelli, Christopher R. McCurdy, Lea R. Gamez Jimenez, Megan Patel, Nicholas P. Ho, Rohan Patel
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f1be33693b410da8f28fe3a2d77203db
https://doi.org/10.1096/fasebj.2021.35.s1.05506
https://doi.org/10.1096/fasebj.2021.35.s1.05506