Výsledky vyhledávání - "Lea Pickering"

Akademický článek

Haemophilus haemolyticus interaction with host cells is different to nontypeable Haemophilus influenzae and prevents NTHi association with epithelial cells

Autor: Janessa Lea Pickering, Amy eProsser, Karli eCorscadden, Camilla ede Gier, Peter C Richmond, Guicheng eZhang, Ruth eThornton, Lea-Ann S Kirkham

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 6 (2016)

Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that resides in the upper respiratory tract and contributes to a significant burden of respiratory related diseases in children and adults. Haemophilus haemolyticus is a respirato

Externí odkaz: https://doaj.org/article/6985bbacb3a7439b91bcab2fd5cc2066

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Preparation, biochemical characterization and biological properties of radiolabelled N-alkylated deoxynojirimycins

Autor: George W. J. Fleet, Mark R. Wormald, Frances M. Platt, Raymond A. Dwek, Terry D. Butters, Howard R. Mellor, James Nolan, Lea Pickering

Publikováno v: ResearcherID

We have reductively alkylated deoxynojirimycin imino sugars using sodium cyanoborohydride to provide an efficient means of generating a series of N-alkylated compounds containing 4-18 carbon side chains. The yields were greater than 90% using a varie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da1038cc26af24beed759bec6d6603a
https://doi.org/10.1042/bj20020466

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Concise and stereospecific synthesis of novel bicyclic dideoxynucleosides as potential antiviral agents

Autor: Qi Chao, Lea Pickering, Jianzhong Zhang, Tamera S. Jahnke, Vasu Nair

Publikováno v: Tetrahedron. 54:3113-3124

A novel class of dideoxynucleosides containing a bicyclic sugar moiety, structurally related to the natural griseolic acids, was synthesized starting from the stereochemically defined compound, 1,4:3,6-dianhydro-D-glucitol. The key intermediate in th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fce5fd026b6cfd1549bc02d64e4615fe
https://doi.org/10.1016/s0040-4020(98)00061-1

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Synthesis of casuarines [pentahydroxylated pyrrolizidines] by sodium hydrogen telluride-induced cyclisations of azidodimesylates

Autor: Alison Ann Watson, Alan D. Elbein, Yuan T. Pan, Robert J. Nash, Andrew A. Bell, Lea Pickering, George W. J. Fleet

Publikováno v: Tetrahedron Letters. 38:5869-5872

The key step in the synthesis of four diastereomers of casuarine from eight carbon sugar lactones is the efficient reduction of open chain azidodimesylates by sodium hydrogen telluride [Suzuki-Takaoka reduction] to allow the formation of the pyrroliz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::635d07282d32da44c96aacac1fca4932
https://doi.org/10.1016/s0040-4039(97)01306-3

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Novel Bicyclic Nucleoside Analogues Related to Natural Griseolic Acids

Autor: Vasu Nair, Lea Pickering

Publikováno v: Nucleosides and Nucleotides. 16:1435-1438

Methodologies for the synthesis of novel isomeric nucleosides related to the natural, biologically-active griseolic acids are described. The carbohydrate precursor for the synthesis, 1,4:3,6-dianhydro-d-glucitol, can be prepared easily from d-glucito

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9b845d6e4969b1b71a46db8d12cfa260
https://doi.org/10.1080/07328319708006200

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SYNTHESIS OF NOVEL BICYCLIC NUCLEOSIDES RELATED TO NATURAL GRISEOLIC ACIDS

Autor: Vasu Nair, Lea Pickering

Publikováno v: Nucleosides and Nucleotides. 15:1751-1769

Synthesis of novel, bicyclic nucleosides related to natural griseolic acids is described. The synthetic approach involves nucleobase construction at the C-2′ position of 1,4:3,6-diandydro-D-mannitol. The carbohydrate precursor used in the synthesis

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae5bd0e4a9f7579248be0557d90135d4
https://doi.org/10.1080/07328319608002730

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