Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lea Paolini"'
Autor:
Thi Tran, Jean-Remi Lavillegrand, Cedric Lereverend, Bruno Esposito, Lucille Cartier, Melanie Montabord, Jaouen Tran-Rajau, Marc Diedisheim, Nadège Gruel, Khadija Ouguerram, Lea Paolini, Olivia Lenoir, Emmanuel Pinteaux, Eva Brabencova, Corinne Tanchot, Pauline Urquia, Jacqueline Lehmann-Che, Richard Le Naour, Yacine Merrouche, Christian Stockmann, Ziad Mallat, Alain Tedgui, Hafid Ait-Oufella, Eric Tartour, Stephane Potteaux
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Obesity and inflammation have been associated to cancer progression. Here, the authors show that high fat and cholesterol diet, in a non-obese context, promotes tumourigenesis through increasing inflammatory monocytes and myeloid-derived pro-angiogen
Externí odkaz:
https://doaj.org/article/9d1b5cbfa4cd4a4690d9acceffb058b5
Publikováno v:
Bulletin de l'Académie Nationale de Médecine. 205:354-363
Resume Bien que de nombreuses cellules immunes jouent un role dans les mecanismes d’action de l’immunotherapie anti-tumorale, les LT-CD8 sont le plus souvent consideres comme les effecteurs majeurs. Au cours de ces dernieres annees de nouvelles t
Autor:
Thi, Tran, Jean-Remi, Lavillegrand, Cedric, Lereverend, Bruno, Esposito, Lucille, Cartier, Melanie, Montabord, Jaouen, Tran-Rajau, Marc, Diedisheim, Nadège, Gruel, Khadija, Ouguerram, Lea, Paolini, Olivia, Lenoir, Emmanuel, Pinteaux, Eva, Brabencova, Corinne, Tanchot, Pauline, Urquia, Jacqueline, Lehmann-Che, Richard, Le Naour, Yacine, Merrouche, Christian, Stockmann, Ziad, Mallat, Alain, Tedgui, Hafid, Ait-Oufella, Eric, Tartour, Stephane, Potteaux
Publikováno v:
Nature communications. 13(1)
Cancer and cardiovascular disease (CVD) share common risk factors such as dyslipidemia, obesity and inflammation. However, the role of pro-atherogenic environment and its associated low-grade inflammation in tumor progression remains underexplored. H
Autor:
Antonin Saldmann, Lea Paolini, Céleste Lebbé, Eléonore De Guillebon, Sylvie Séguier, Antoine Dardenne, Thi Anh-Dao Tran, Eric Tartour
Publikováno v:
International journal of cancerReferences. 147(6)
Immunotherapy has revolutionized the management of cancers. At the end of 2018, 1,716 clinical trials assessed regimen that combine program death-1 (PD-1)/program death ligand-1 (PD-L1) blockers with other cancer therapies (tyrosine kinase inhibitor,
Autor:
Clément Adam, Léa Paolini, Naïg Gueguen, Guillaume Mabilleau, Laurence Preisser, Simon Blanchard, Pascale Pignon, Florence Manero, Morgane Le Mao, Alain Morel, Pascal Reynier, Céline Beauvillain, Yves Delneste, Vincent Procaccio, Pascale Jeannin
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Lactic acidosis is a metabolic state that occurs in injured tissues. Here the authors show that macrophages, in order to remain functional in acidosis, reduce their mitochondrial mass by mitophagy and rely on autophagy for survival, with mitochondria
Externí odkaz:
https://doaj.org/article/f9179eb3803842ccbdf9957fc814715b
Autor:
Alberto Mantovani, Léa Paolini, Pascale Jeannin, Yves Delneste, Marine Monnier, Emeline Vinatier
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 10 (2022)
Macrophages are the immune cells that accumulate the most in the majority of established tumors and this accumulation is associated with a poor prognosis. Tumor-associated macrophages (TAMs) produce inflammatory cytokines and growth factors that prom
Externí odkaz:
https://doaj.org/article/972227c244ea495bbfb98ed86c85a8a2
Autor:
Diane Damotte, Nadine BenHamouda, Ludger Johannes, Estelle Dransart, Eric Tartour, Emmanuel Donnadieu, Léa Paolini, Fathia Mami-Chouaib, Charlotte Blanc, Sebastian Kobold, Soumaya Karaki, Thi Tran, Isabelle Galy-Fauroux, Alice Mougel, Marie Anson, Corinne Tanchot, Nadege Gruel, Laure Gibault, Francoise Lepimpec-Barhes, Elizabeth Fabre, Cecile Badoual, Rachel Golub
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 3 (2021)
Background Resident memory T lymphocytes (TRM) are located in tissues and play an important role in immunosurveillance against tumors. The presence of TRM prior to treatment or their induction is associated to the response to anti-Programmed cell dea
Externí odkaz:
https://doaj.org/article/7396a1c31d234ef2b59347b1a9805e52
Autor:
Léa Paolini, Caroline Poli, Simon Blanchard, Thierry Urban, Anne Croué, Marie-Christine Rousselet, Sarah Le Roux, Nathalie Labarrière, Pascale Jeannin, José Hureaux
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 6, Iss 1, Pp 1-5 (2018)
Abstract Background Immune checkpoint inhibitors (ICI) target T cell inhibitory pathways that are responsible for cancer tolerance by down-modulating immune functions. ICI have revolutionized patients care with lung cancer. Nevertheless, restoring en
Externí odkaz:
https://doaj.org/article/9a0cdf886fed4c419406cdcf7da2f51b
Autor:
Catherine Rabu, Laurie Rangan, Laetitia Florenceau, Agnès Fortun, Maud Charpentier, Emilie Dupré, Léa Paolini, Céline Beauvillain, Estelle Dupel, Jean-Baptiste Latouche, Olivier Adotevi, Nathalie Labarrière, François Lang
Publikováno v:
OncoImmunology, Vol 8, Iss 4 (2019)
There is now a consensus that efficient peptide vaccination against cancer requires that peptides should (i) be exclusively presented by professional APC and (ii) stimulate both CD4 and CD8-specific T cell responses. To this aim, in recent trials, pa
Externí odkaz:
https://doaj.org/article/f1026e16e4944382a2c78a43cfd2f7c5