Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lea M. Johnson"'
Autor:
Gerald F. Smith, Wayne W. Weber, John Walter Nr Macclesfield Liebeschuetz, Philip Sipes, Jeffry Bernard Franciskovich, Richard D. Towner, John Joseph Masters, Donetta S. Gifford-Moore, Trelia J. Craft, Ronald S. Foster, Jeffrey K. Smallwood, Michael L. Chouinard, Lea M. Johnson, Larry L. Froelich, Stephen C. Young, David W. Snyder, Marcia K. Chastain, Valentine J. Klimkowski, Christopher W. Murray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 17:6910-6913
Several P4 domain derivatives of the general d-phenylglycinamide-based scaffold (2) were synthesized and evaluated for their ability to bind to the serine protease factor Xa. Some of the more potent compounds were evaluated for their anticoagulant ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7308733752c4e2e7235ca66a8d4df0
https://doi.org/10.1016/j.bmcl.2007.09.105
https://doi.org/10.1016/j.bmcl.2007.09.105
Autor:
and Lea M. Johnson, Bryan D. Anderson, Paul Lee, Miriam del Prado, C. Richard NevillJr., Sehila Pleite, Yong Wang, † Jaime Blanco-Urgoiti, Luisa M. Martín Cabrejas, Jeremy Schulenburg York, Robert M. Campbell, Deborah D. Giera, Michal Vieth, Jeffrey A. Wolos, Denis J. McCann, Chuan Shih, Li C. Li, Beatriz López de Uralde, Nicholas A. Magnus, Concepción Sánchez, Rosanne Bonjouklian, Richard M. Schultz, María José Lorite, Alfonso De Dios
Publikováno v:
Journal of Medicinal Chemistry. 48:2270-2273
We report the design and discovery of a 2-aminobenzimidazole-based series of potent and highly selective p38alphainhibitors. The lead compound 1 had low-nanomolar activity in both ATP competitive enzyme binding and inhibition of TNFalpha release in m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c105a28691f426c1b73e9b9ed314fcb
https://doi.org/10.1021/jm048978k
https://doi.org/10.1021/jm048978k
Autor:
Sau-Chi B. Yan, Michael L. Denney, Valentine J. Klimkowski, Amy J. Smith, Lea M. Johnson, Michael Enrico Richett, Minsheng Zhang, Jefferson Ray Mccowan, Kumiko Takeuchi, Todd J. Kohn, Nickolay Y. Chirgadze, Jolie Anne Bastian, Dianna L. Bailey, Donetta S. Gifford-Moore, Barbara G. Utterback, Gerald F. Smith, Daniel Jon Sall, David K. Clawson, Richard Waltz Harper, David W. Snyder, Stephen L. Briggs, Ho-Shen Lin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:775-780
Potent, subnanomolar thrombin inhibitors 4, 5, and 6 are developed through side chain optimization of novel, benzo[b]thiophene-based small organic entities 2 and 3 and through SAR additivity studies of the new structural elements identified. X-ray cr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dbe7d35a63ca810bf308f9e6a8bf352
https://doi.org/10.1016/s0960-894x(99)00074-8
https://doi.org/10.1016/s0960-894x(99)00074-8
Autor:
Bach Nicholas J, Dennis R. Berry, Robert D. Dillard, Edward David Mihelich, Jean-Pierre Wery, Cynthia D. Sommers, Lea M. Johnson, David W. Snyder, Donald G. Carlson, David K. Clawson, Emma R. McKinney, Amy C. Smith, Richard Walter Schevitz, Susan E. Draheim, Lawrence W. Hartley, Jennifer L. Olkowski, Noel D. Jones, Nickolay Y. Chirgadze
Publikováno v:
Journal of Medicinal Chemistry. 39:5137-5158
As reported in our previous paper, a series of indole-3-acetamides which possessed potency and selectivity as inhibitors of human nonpancreatic secretory phospholipase A2(hnps-PLA2) was developed. The design of these compounds was based on informatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdb0858e7cadcd119a6d3f11a160b093
https://doi.org/10.1021/jm960486n
https://doi.org/10.1021/jm960486n
Autor:
Robert D. Dillard, Susan E. Draheim, Bach Nicholas J, Cynthia D. Sommers, Amy C. Smith, Emma R. McKinney, Noel D. Jones, Jennifer L. Olkowski, Edward David Mihelich, Jean-Pierre Wery, David W. Snyder, Lawrence W. Hartley, Donald G. Carlson, Richard Walter Schevitz, Nickolay Y. Chirgadze, Dennis R. Berry, David K. Clawson, Lea M. Johnson
Publikováno v:
Journal of Medicinal Chemistry. 39:5159-5175
Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96a4d3e2c3e6fd72e60021a3469bd5da
https://doi.org/10.1021/jm960487f
https://doi.org/10.1021/jm960487f
Autor:
Amy C. Smith, Lea M. Johnson, Robert D. Dillard, Lawrence W. Hartley, Donald G. Carlson, Noel D. Jones, Nickolay Y. Chirgadze, Emma R. McKinney, Richard Walter Schevitz, Susan E. Draheim, Jennifer L. Olkowski, Bach Nicholas J, Dennis R. Berry, David W. Snyder, Jean-Pierre Wery, Cynthia D. Sommers, David K. Clawson, Edward David Mihelich
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2dccdd1798a2a7acf8d0453faf4a3f38
https://doi.org/10.1002/chin.199716152
https://doi.org/10.1002/chin.199716152
Autor:
Donald G. Carlson, Cynthia D. Sommers, Richard Walter Schevitz, Bach Nicholas J, Susan E. Draheim, Edward David Mihelich, Nickolay Y. Chirgadze, Amy C. Smith, Jennifer L. Olkowski, David K. Clawson, Jean-Pierre Wery, Robert D. Dillard, Noel D. Jones, David W. Snyder, Emma R. McKinney, Dennis R. Berry, Lea M. Johnson, Lawrence W. Hartley
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18953de424a69d0b1c2580eceb94fb59
https://doi.org/10.1002/chin.199716151
https://doi.org/10.1002/chin.199716151
Autor:
Gerald F. Smith, Matthew J. Fisher, John E. Toth, Nickolay Y. Chirgadze, Deborah D. Giera, Dianna L. Bailey, John A. Buben, Amy Clemens-Smith, Michael L. Denney, Michael Enrico Richett, Richard Waltz Harper, Jolie Anne Bastian, Alan David Palkowitz, Minsheng Zhang, Valentine J. Klimkowski, Todd J. Kohn, Jefferson Ray Mccowan, Kumiko Takeuchi, Ho-Shen Lin, Daniel Jon Sall, Donetta S. Gifford-Moore, Lea M. Johnson, David W. Snyder
Publikováno v:
Journal of medicinal chemistry. 43(4)
A systematic investigation of the structure-activity relationships of the C-3 side chain of the screening hit 1a led to the identification of the potent thrombin inhibitors 23c, 28c, and 31c. Their activities (1240, 903, and 1271 x 10(6) L/mol, respe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71b65bb93c4bac89d1ca25c10915de94
https://pubmed.ncbi.nlm.nih.gov/10691691
https://pubmed.ncbi.nlm.nih.gov/10691691
Autor:
David W. Snyder, Philippe Bridonneau, Ying-Fon Chang, Lea M. Johnson, Theodore Goodson, David H. Parma, David K. Herron, Dan O'connell, Stanley C. Gill
Publikováno v:
Journal of medicinal chemistry. 41(6)
A family of sequence-related 2'-aminopyrimidine, 2'-hydroxylpurine aptamers, developed by oligonucleotide-based combinatorial chemistry, SELEX (systematic evolution of ligand by exponential enrichment) technology, binds human nonpancreatic secretory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85cb4d0cd494e70739b0e4969db709a8
https://pubmed.ncbi.nlm.nih.gov/9526554
https://pubmed.ncbi.nlm.nih.gov/9526554
Autor:
Robert D. Dillard, Nicholas J. Bach, Susan E. Draheim, Dennis R. Berry, Donald G. Carlson, Nickolay Y. Chirgadze, David K. Clawson, Lawrence W. Hartley, Lea M. Johnson, Noel D. Jones, Emma R. McKinney, Edward D. Mihelich, Jennifer L. Olkowski, Richard W. Schevitz, Amy C. Smith, David W. Snyder, Cynthia D. Sommers, Jean-Pierre Wery
Publikováno v:
Journal of medicinal chemistry. 39(26)
Phospholipases (PLAs) produce rate-limiting precursors in the biosynthesis of various types of biologically active lipids involved in inflammatory processes. Increased levels of human nonpancreatic secretory phospholipase A2 (hnps-PLA2) have been det
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258b47ef40521e42d74456539df7f156
https://pubmed.ncbi.nlm.nih.gov/9005255
https://pubmed.ncbi.nlm.nih.gov/9005255