Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Lea M. Beaulieu"'
Publikováno v:
Platelets, Vol 28, Iss 5, Pp 472-477 (2017)
Platelets, responsible for clot formation and blood vessel repair, are produced by megakaryocytes in the bone marrow. Platelets are critical for hemostasis and wound healing, and are often provided following surgery, chemotherapy, and major trauma. D
Externí odkaz:
https://doaj.org/article/8d949c1fb30a491faef77a4cc8d904b0
Autor:
Lea M Beaulieu, Lauren Clancy, Kahraman Tanriverdi, Emelia J Benjamin, Carolyn D Kramer, Ellen O Weinberg, Xianbao He, Samrawit Mekasha, Eric Mick, Robin R Ingalls, Caroline A Genco, Jane E Freedman
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131688 (2015)
Diverse and multi-factorial processes contribute to the progression of cardiovascular disease. These processes affect cells involved in the development of this disease in varying ways, ultimately leading to atherothrombosis. The goal of our study was
Externí odkaz:
https://doaj.org/article/03a1693fba2946d0abb31ea1dbc220c3
Publikováno v:
Platelets. 28:472-477
Platelets, responsible for clot formation and blood vessel repair, are produced by megakaryocytes in the bone marrow. Platelets are critical for hemostasis and wound healing, and are often provided following surgery, chemotherapy, and major trauma. D
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ec97d1a37e7a4708f87ce36d4033519
https://doi.org/10.1080/09537104.2016.1265922
https://doi.org/10.1080/09537104.2016.1265922
Autor:
Lea M. Beaulieu, Emelia J. Benjamin, John F. Keaney, Jane E. Freedman, Kahraman Tanriverdi, Eric Mick, Martin G. Larson, David D. McManus
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33:2666-2673
Objective— Cardiovascular disease is a complex disorder influenced by interactions of genetic variants with environmental factors. However, there is no information from large community-based studies examining the relationship of circulating cell–
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab42f2644aba7a3d821da0c05b6160d6
https://doi.org/10.1161/atvbaha.112.301112
https://doi.org/10.1161/atvbaha.112.301112
Publikováno v:
Thrombosis and haemostasis. 117(5)
SummaryThe role of platelets in regulating vascular homeostasis has expanded beyond mediation of haemostasis and thrombosis. The discovery of platelet RNA and the presence of subpopulations of platelets containing varying amounts of RNA suggest a rol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783c71fa291f36fa71fb6d5aacaecd93
https://pubmed.ncbi.nlm.nih.gov/28276570
https://pubmed.ncbi.nlm.nih.gov/28276570
Autor:
James K. Liao, Nikola Sladojevic, Goo Taeg Oh, Karol Kamiński, Hervé Falet, Jane E. Freedman, Hyung-Hwan Kim, Lea M. Beaulieu
Publikováno v:
Cardiovascular research. 113(11)
Aims Rho-associated coiled-coil containing kinase (ROCK)-2 is an important mediator of the actin cytoskeleton. Because changes in the actin cytoskeleton are critical for platelet function, we hypothesized that ROCK2 in platelets will play important r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e036a418b08b68801da824b01be6d743
https://pubmed.ncbi.nlm.nih.gov/28859303
https://pubmed.ncbi.nlm.nih.gov/28859303
Autor:
Fabio C. P. Navarro, Raymond Y. Kwong, Robert R. Kitchen, Yaoyu E. Wang, Kirsty Danielson, Ravi V. Shah, Lea M. Beaulieu, Timur R. Galeev, Saumya Das, Venkatesh L. Murthy, Mark Gerstein, Selim E. Tanriverdi, Jane E. Freedman, Daniel Levy, Kahraman Tanriverdi, Eric Mick, Joel Rozowsky, Alex Holman, Milka Koupenova-Zamor, Ekaterina Mikhalev
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
There is growing appreciation for the importance of non-protein-coding genes in development and disease. Although much is known about microRNAs, limitations in bioinformatic analyses of RNA sequencing have precluded broad assessment of other forms of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8f1775b4c807479ca8b65ac16964a1
https://doi.org/10.1038/ncomms11106
https://doi.org/10.1038/ncomms11106
Autor:
Caroline A. Genco, Sybille Rex, Price Blair, Olga Vitseva, Chie Hayashi, Lea M. Beaulieu, Jane E. Freedman, Mark D. Iafrati, Subrata Chakrabarti, Kahraman Tanriverdi
Publikováno v:
Circulation Research. 104:346-354
Cells of the innate immune system use Toll-like receptors (TLRs) to initiate the proinflammatory response to microbial infection. Recent studies have shown acute infections are associated with a transient increase in the risk of vascular thrombotic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ed636262bf0b1e2889017a400ff214
https://doi.org/10.1161/circresaha.108.185785
https://doi.org/10.1161/circresaha.108.185785
Autor:
David H. Perlman, Lea M. Beaulieu, Jane E. Freedman, Olga Vitseva, Sybille Rex, Catherine E. Costello, Price Blair, Mark E. McComb
Publikováno v:
Thrombosis and Haemostasis. 102:97-110
SummaryIn addition to haemostasis, platelets mediate inflammation and clearance of bacteria from the bloodstream. As with platelet-platelet interactions, platelet-bacteria interactions involve cytoskeletal rearrangements and release of granular conte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ced83c54f4288d583ad6b0d0b2b380
https://doi.org/10.1160/th08-08-0513
https://doi.org/10.1160/th08-08-0513
Publikováno v:
Journal of Thrombosis and Haemostasis. 5:102-115
Hemostasis and fibrinolysis, the biological processes that maintain proper blood flow, are the consequence of a complex series of cascading enzymatic reactions. Serine proteases involved in these processes are regulated by feedback loops, local cofac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0737500eb1aee9f4e87cae8721c167d9
https://doi.org/10.1111/j.1538-7836.2007.02516.x
https://doi.org/10.1111/j.1538-7836.2007.02516.x