Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lea M, Hürlimann"'
Autor:
Cedric A. J. Hutter, M. Hadi Timachi, Lea M. Hürlimann, Iwan Zimmermann, Pascal Egloff, Hendrik Göddeke, Svetlana Kucher, Saša Štefanić, Mikko Karttunen, Lars V. Schäfer, Enrica Bordignon, Markus A. Seeger
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
ABC exporters hydrolyze ATP to pump substrates across membranes, but critical steps of the transport mechanism remain poorly understood. Here, the authors solve the crystal structure of outward-facing TM287/288 with the help of a state-specific sybod
Externí odkaz:
https://doaj.org/article/10e4f9ba103940ba80927107a3cf8a89
Autor:
Gianmarco Meier, Sujani Thavarasah, Kai Ehrenbolger, Cedric A. J. Hutter, Lea M. Hürlimann, Jonas Barandun, Markus A. Seeger
Publikováno v:
Nat Chem Biol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52483d682bd3ee6acac5056f6e2d07ba
Rapid phenotypic antimicrobial susceptibility testing (AST) requires the enrichment of live bacteria from patient samples, which is particularly challenging in the context of life-threatening bloodstream infections (BSIs) due to low bacterial titers.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef6f87aba5a7f2a7c6d2df57f5c85910
Autor:
Gianmarco, Meier, Sujani, Thavarasah, Kai, Ehrenbolger, Cedric A J, Hutter, Lea M, Hürlimann, Jonas, Barandun, Markus A, Seeger
Publikováno v:
Nature chemical biology.
Drug efflux is a common resistance mechanism found in bacteria and cancer cells, but studies providing comprehensive functional insights are scarce. In this study, we performed deep mutational scanning (DMS) on the bacterial ABC transporter EfrCD to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0ec8a3adb5c7d218e945651560a3980f
https://pubmed.ncbi.nlm.nih.gov/36443574
https://pubmed.ncbi.nlm.nih.gov/36443574
Autor:
Pascal Egloff, Markus A. Seeger, Saša Štefanić, Lea M. Hürlimann, Cedric A. J. Hutter, Enrica Bordignon, Hendrik Göddeke, Mikko Karttunen, Lars V. Schäfer, Iwan Zimmermann, M. Hadi Timachi, Svetlana Kucher
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications
Nature Communications
ABC exporters harness the energy of ATP to pump substrates across membranes. Extracellular gate opening and closure are key steps of the transport cycle, but the underlying mechanism is poorly understood. Here, we generated a synthetic single domain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::653508ffd7b661b4320addf009de7472
http://link.springer.com/article/10.1038/s41467-019-09892-6
http://link.springer.com/article/10.1038/s41467-019-09892-6
Autor:
Benedikt T. Kuhn, Iwan Zimmermann, Pascal Egloff, Lea M. Hürlimann, Cedric A.J. Hutter, Christian Miscenic, Roger J.P. Dawson, Markus A. Seeger, Eric R. Geertsma
The selective immobilization of proteins represents an essential step in the selection of binding proteins such as antibodies. The immobilization strategy determines how the target protein is presented to the binders and thereby directly affects the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e91f44c161e81d63919ee447e88d400
https://doi.org/10.17504/protocols.io.bpinmkde
https://doi.org/10.17504/protocols.io.bpinmkde
Autor:
Lea M. Hürlimann, Pascal Egloff, I. Gonda, Justin D. Walter, M. Sorgenfrei, Sille Remm, Markus A. Seeger, Marianne Wyss, Iwan Zimmermann, S. Thavarasah, Philippe Plattet, Gianmarco Meier, Cedric A. J. Hutter
The COVID-19 pandemic, caused by the novel coronavirus SARS-CoV-2, has resulted in a global health and economic crisis of unprecedented scale. The high transmissibility of SARS-CoV-2, combined with a lack of population immunity and prevalence of seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c360d1298bea7eceb11a681b8541dd0
https://doi.org/10.1101/2020.04.16.045419
https://doi.org/10.1101/2020.04.16.045419
Autor:
Benedikt T, Kuhn, Iwan, Zimmermann, Pascal, Egloff, Lea M, Hürlimann, Cedric A J, Hutter, Christian, Miscenic, Roger J P, Dawson, Markus A, Seeger, Eric R, Geertsma
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2127
The selective immobilization of proteins represents an essential step in the selection of binding proteins such as antibodies. The immobilization strategy determines how the target protein is presented to the binders and thereby directly affects the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5668c4a74b9001ba57345ae5cb11be27
https://pubmed.ncbi.nlm.nih.gov/32112321
https://pubmed.ncbi.nlm.nih.gov/32112321
Autor:
Roger J. P. Dawson, Markus A. Seeger, Pascal Egloff, Eric R. Geertsma, Iwan Zimmermann, Cedric A. J. Hutter, Christian Miscenic, Benedikt T Kuhn, Lea M. Hürlimann
Publikováno v:
Methods in Molecular Biology ISBN: 9781071603727
The selective immobilization of proteins represents an essential step in the selection of binding proteins such as antibodies. The immobilization strategy determines how the target protein is presented to the binders and thereby directly affects the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b424f3c68e9441391fb7b81386de0428
https://www.zora.uzh.ch/id/eprint/196535/
https://www.zora.uzh.ch/id/eprint/196535/
Publikováno v:
The FEBS Journal. 284:1672-1687
Many heterodimeric ATP-binding cassette (ABC) exporters evolved asymmetric ATP-binding sites containing a degenerate site incapable of ATP hydrolysis due to noncanonical substitutions in conserved sequence motifs. Recent studies revealed that nucleot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ec3580748a2c20b86c8af73c7804bda
https://doi.org/10.1111/febs.14065
https://doi.org/10.1111/febs.14065