Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lea Langhoff, Thuesen"'
Autor:
Malene Lundgaard Riis, Gaspard Delpouve, John E. Nielsen, Cecilie Melau, Lea Langhoff Thuesen, Kristine Juul Hare, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Jakob Albrethsen, Hanne Frederiksen, Anders Juul, Paolo Giacobini, Anne Jørgensen
Publikováno v:
Cell Communication and Signaling, Vol 22, Iss 1, Pp 1-19 (2024)
Abstract Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously inhibiting the opposite pathway. In mice, the WNT/β-catenin pathway promotes ovarian devel
Externí odkaz:
https://doaj.org/article/9ba84127f86e43e4b357207164f53583
Autor:
Malene Lundgaard Riis, Gabriele Matilionyte, John E. Nielsen, Cecilie Melau, David Greenald, Kristine Juul Hare, Lea Langhoff Thuesen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Anna-Maria Andersson, Jakob Albrethsen, Hanne Frederiksen, Ewa Rajpert-De Meyts, Anders Juul, Rod T. Mitchell, Anne Jørgensen
Publikováno v:
BMC Medicine, Vol 20, Iss 1, Pp 1-18 (2022)
Abstract Background Reduced androgen action during early fetal development has been suggested as the origin of reproductive disorders comprised within the testicular dysgenesis syndrome (TDS). This hypothesis has been supported by studies in rats dem
Externí odkaz:
https://doaj.org/article/6faa0696ef594229b30882d592bea05d
Autor:
Cecilie Melau, Berta Gayete Mor, Malene Lundgaard Riis, John E. Nielsen, Eva Dreisler, Kasper Aaboe, Pia Tutein Brenøe, Lea Langhoff Thuesen, Kristine Juul Hare, Rod T. Mitchell, Hanne Frederiksen, Anders Juul, Anne Jørgensen
Publikováno v:
Frontiers in Endocrinology, Vol 14 (2023)
IntroductionAdministration of dexamethasone (DEX) has been used experimentally to suppress androgenization of external genitalia in 46,XX fetuses with congenital adrenal hyperplasia. Despite this, the prenatal biological mechanism-of-action of DEX on
Externí odkaz:
https://doaj.org/article/9b1a8f93d0f24ffb836d637b277bbce2
Autor:
Cecilie Melau, Malene Lundgaard Riis, John E. Nielsen, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Mette Schou Hammerum, Rod T. Mitchell, Hanne Frederiksen, Anders Juul, Anne Jørgensen
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Abstract Background Disordered fetal adrenal steroidogenesis can cause marked clinical effects including virilization of female fetuses. In postnatal life, adrenal disorders can be life-threatening due to the risk of adrenal crisis and must be carefu
Externí odkaz:
https://doaj.org/article/4b092556ccf84c61a965df50527835b1
Autor:
Carla A. Gonçalves, Michael Larsen, Sascha Jung, Johannes Stratmann, Akiko Nakamura, Marit Leuschner, Lena Hersemann, Rashmiparvathi Keshara, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Ido Amit, Anne Jørgensen, Yung Hae Kim, Antonio del Sol, Anne Grapin-Botton
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
From single-cell transcriptome analyses to defining culture media for spheroids, the authors provide a census of information to understand the development of human pancreatic progenitors. This approach identifies signalling pathways (EGF and FGF) reg
Externí odkaz:
https://doaj.org/article/4dd4448416d0483cbbb89a084390dda1
Autor:
Anne Jørgensen, Joni Macdonald, John E. Nielsen, Karen R. Kilcoyne, Signe Perlman, Lene Lundvall, Lea Langhoff Thuesen, Kristine Juul Hare, Hanne Frederiksen, Anna-Maria Andersson, Niels E. Skakkebæk, Anders Juul, Richard M. Sharpe, Ewa Rajpert-De Meyts, Rod T. Mitchell
Publikováno v:
Cell Reports, Vol 25, Iss 7, Pp 1924-1937.e4 (2018)
Summary: Disruption of human fetal testis development is widely accepted to underlie testicular germ cell cancer (TGCC) origin and additional disorders within testicular dysgenesis syndrome (TDS). However, the mechanisms for the development of testic
Externí odkaz:
https://doaj.org/article/089665c4e31345bd98eafb2ae5ef95e7
Autor:
Rehannah Borup, Lea Langhoff Thuesen, Claus Yding Andersen, Anders Nyboe-Andersen, Søren Ziebe, Ole Winther, Marie Louise Grøndahl
Publikováno v:
PLoS ONE, Vol 11, Iss 4, p e0153562 (2016)
OBJECTIVE:By focussing on differences in the mural granulosa cell (MGC) and cumulus cell (CC) transcriptomes from follicles resulting in competent (live birth) and non-competent (no pregnancy) oocytes the study aims on defining a competence classifie
Externí odkaz:
https://doaj.org/article/7a015805e0ab469e94687adc438ecf41
Autor:
Lea Langhoff, Thuesen, Birgitte, Oxlund-Mariegaard, Lene Hee, Christensen, Lars Franch, Andersen, Bent Brandt, Hansen, Anette Tønnes, Pedersen, Bugge, Nøhr
Publikováno v:
Ugeskrift for laeger. 183(48)
Although assisted reproductive technology has reduced the need for surgery for women with infertility, there is evidence to support, that targeted reproductive surgery can improve fertility and pregnancy outcomes. In the last decades, increased acces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a524940a888221b1403ae6d79795c921
https://pubmed.ncbi.nlm.nih.gov/34852909
https://pubmed.ncbi.nlm.nih.gov/34852909
Autor:
Lea Langhoff Thuesen, Cecilie Melau, John E Nielsen, Lene Lundvall, Mette Schou Hammerum, Malene Lundgaard Riis, Anders Juul, Kristine Juul Hare, Rod T. Mitchell, Anne Jørgensen, Signe Perlman, Hanne Frederiksen
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-17 (2021)
Melau, C, Riis, M L, Nielsen, J E, Perlman, S, Lundvall, L, Thuesen, L L, Hare, K J, Hammerum, M S, Mitchell, R T, Frederiksen, H, Juul, A & Jørgensen, A 2021, ' The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions ', BMC Medicine, vol. 19, 204 . https://doi.org/10.1186/s12916-021-02080-8
BMC Medicine
Melau, C, Riis, M L, Nielsen, J E, Perlman, S, Lundvall, L, Thuesen, L L, Hare, K J, Hammerum, M S, Mitchell, R T, Frederiksen, H, Juul, A & Jørgensen, A 2021, ' The effects of selected inhibitors on human fetal adrenal steroidogenesis differs under basal and ACTH-stimulated conditions ', BMC Medicine, vol. 19, 204 . https://doi.org/10.1186/s12916-021-02080-8
BMC Medicine
Background Disordered fetal adrenal steroidogenesis can cause marked clinical effects including virilization of female fetuses. In postnatal life, adrenal disorders can be life-threatening due to the risk of adrenal crisis and must be carefully manag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::831f86f2de06930c5bde41963465cfbc
https://doi.org/10.1186/s12916-021-02080-8
https://doi.org/10.1186/s12916-021-02080-8
Autor:
Yung Hae Kim, Anne Grapin-Botton, Rashmiparvathi Keshara, Signe Perlman, Sascha Jung, Antonio del Sol, Michael Larsen, Carla A C Gonçalves, Akiko Nakamura, Kristine J. Hare, Lene Lundvall, Lena Hersemann, Johannes Stratmann, Ido Amit, Lea Langhoff Thuesen, Anne Jørgensen, Marit Leuschner
Publikováno v:
Goncalves, C A, Larsen, M, Jung, S, Stratmann, J, Nakamura, A, Leuschner, M, Hersemann, L, Keshara, R, Perlman, S, Lundvall, L, Thuesen, L L, Hare, K J, Amit, I, Jørgensen, A, Kim, Y H, del Sol, A & Grapin-Botton, A 2021, ' A 3D system to model human pancreas development and its reference single-cell transcriptome atlas identify signaling pathways required for progenitor expansion ', Nature Communications, vol. 12, 3144 . https://doi.org/10.1038/s41467-021-23295-6
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Human organogenesis remains relatively unexplored for ethical and practical reasons. Here, we report the establishment of a single-cell transcriptome atlas of the human fetal pancreas between 7 and 10 post-conceptional weeks of development. To interr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::015b3dc2a4cab00c0944a7f613c56104
https://doi.org/10.21203/rs.3.pex-1430/v1
https://doi.org/10.21203/rs.3.pex-1430/v1
