Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lea Krutzke"'
Autor:
Dominik Pflumm, Alina Seidel, Fabrice Klein, Rüdiger Groß, Lea Krutzke, Stefan Kochanek, Joris Kroschel, Jan Münch, Katja Stifter, Reinhold Schirmbeck
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
A multitude of alterations in the old immune system impair its functional integrity. Closely related, older individuals show, for example, a reduced responsiveness to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) vaccines. However, sys
Externí odkaz:
https://doaj.org/article/1395366881924627908397826e673d79
Autor:
Robin Nilson, Olivia Lübbers, Christoph Q. Schmidt, Markus Rojewski, Philip Helge Zeplin, Wolfgang Funk, Hubert Schrezenmeier, Astrid Kritzinger, Stefan Kochanek, Lea Krutzke
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 25, Iss , Pp 96-110 (2022)
In adenovirus type 5 (HAdV-5)-derived viral vectors, the fiber protein has been the preferred locale for modifications to alter the natural viral tropism. Hexon, the most abundant capsid protein, has rarely been used for retargeting purposes, likely
Externí odkaz:
https://doaj.org/article/87a64ed911c04f28ab8c34275b460b7b
Autor:
Lea Krutzke, Reinhild Rösler, Ellen Allmendinger, Tatjana Engler, Sebastian Wiese, Stefan Kochanek
Publikováno v:
eLife, Vol 11 (2022)
ChAdOx1 nCov-19 and Ad26.COV2.S are approved vaccines inducing protective immunity against SARS-CoV-2 infection in humans by expressing the Spike protein of SARS-CoV-2. We analyzed protein content and protein composition of ChAdOx1 nCov-19 and Ad26.C
Externí odkaz:
https://doaj.org/article/b1837221b5b54b429022fca3c3496716
Autor:
Alberto Reale, Lea Krutzke, Massimiliano Cadamuro, Adriana Vitiello, Jens von Einem, Stefan Kochanek, Giorgio Palù, Cristina Parolin, Arianna Calistri
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 11, p 9255 (2023)
Oncolytic viruses (OVs) are promising therapeutics for tumors with a poor prognosis. An OV based on herpes simplex virus type 1 (oHSV-1), talimogene laherparepvec (T-VEC), has been recently approved by the Food and Drug Administration (FDA) and by th
Externí odkaz:
https://doaj.org/article/8006284d892c4f1eba4859bdd91ed004
Autor:
Eric Kowarz, Lea Krutzke, Marius Külp, Patrick Streb, Patrizia Larghero, Jennifer Reis, Silvia Bracharz, Tatjana Engler, Stefan Kochanek, Rolf Marschalek
Publikováno v:
eLife, Vol 11 (2022)
To fight the COVID-19 pandemic caused by the RNA virus SARS-CoV-2, a global vaccination campaign is in progress to achieve the immunization of billions of people mainly with adenoviral vector- or mRNA-based vaccines, all of which encode the SARS-CoV-
Externí odkaz:
https://doaj.org/article/30a61e87efa345b19c61d8c01cdaf176
Autor:
Robin Nilson, Lea Krutzke, Frederik Wienen, Markus Rojewski, Philip Helge Zeplin, Wolfgang Funk, Hubert Schrezenmeier, Stefan Kochanek, Astrid Kritzinger
Publikováno v:
Viruses, Vol 15, Iss 1, p 218 (2023)
Human multipotent mesenchymal stromal cells (hMSCs) are of significant therapeutic interest due to their ability to deliver oncolytic adenoviruses to tumors. This approach is also investigated for targeting head and neck squamous cell carcinomas (HNS
Externí odkaz:
https://doaj.org/article/f654d58ce153423188ee81951f081c8b
Autor:
Dirk M. Nettelbeck, Mathias F. Leber, Jennifer Altomonte, Assia Angelova, Julia Beil, Susanne Berchtold, Maike Delic, Jürgen Eberle, Anja Ehrhardt, Christine E. Engeland, Henry Fechner, Karsten Geletneky, Katrin Goepfert, Per Sonne Holm, Stefan Kochanek, Florian Kreppel, Lea Krutzke, Florian Kühnel, Karl Sebastian Lang, Antonio Marchini, Markus Moehler, Michael D. Mühlebach, Ulrike Naumann, Roman Nawroth, Jürg Nüesch, Jean Rommelaere, Ulrich M. Lauer, Guy Ungerechts
Publikováno v:
Viruses, Vol 13, Iss 8, p 1420 (2021)
Virotherapy research involves the development, exploration, and application of oncolytic viruses that combine direct killing of cancer cells by viral infection, replication, and spread (oncolysis) with indirect killing by induction of anti-tumor immu
Externí odkaz:
https://doaj.org/article/2afbc836e8844aa9a40984a8fca1af73
Autor:
Robin Nilson, Olivia Lübbers, Linus Weiß, Karmveer Singh, Karin Scharffetter-Kochanek, Markus Rojewski, Hubert Schrezenmeier, Philip Helge Zeplin, Wolfgang Funk, Lea Krutzke, Stefan Kochanek, Astrid Kritzinger
Publikováno v:
Viruses, Vol 13, Iss 6, p 1136 (2021)
Human multipotent mesenchymal stromal cells (hMSCs) are currently developed as cell therapeutics for different applications, including regenerative medicine, immune modulation, and cancer treatment. The biological properties of hMSCs can be further m
Externí odkaz:
https://doaj.org/article/b165f309c7314ab0a465917d531a36dd
Autor:
Rebecca C. Feiner, Isabell Kemker, Lea Krutzke, Ellen Allmendinger, Daniel J. Mandell, Norbert Sewald, Stefan Kochanek, Kristian M. Müller
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 24, p 9535 (2020)
The epidermal growth factor receptor (EGFR) plays a central role in the progression of many solid tumors. We used this validated target to analyze the de novo design of EGFR-binding peptides and their application for the delivery of complex payloads
Externí odkaz:
https://doaj.org/article/6d9107ef918a4d15bf79a9a441e288d6
Autor:
Andreas Büttner, Michael Lalk, Raghavendra Palankar, Stefan Kochanek, Reiner K. Mailer, Evi X. Stavrou, Uwe Völker, Karen Methling, Thomas Renné, Konstanze Aurich, Leif Steil, Thomas Thiele, Lea Krutzke, Martin Beer, Maike Frye, Kathleen Selleng, Theodore E. Warkentin, Chandini Rangaswamy, Hanna Englert, Martina Wolff, Stephan Michalik, Linda Schönborn, Nicole Endlich, Florian Siegerist, Alexander Reder, Boris Fehse, Christian Hentschker, Jan Wesche, Stefan Handtke, Andreas Greinacher, Kati Franzke
Publikováno v:
Blood
SARS-CoV-2 vaccine ChAdOx1 nCoV-19 (AstraZeneca) causes a thromboembolic complication termed vaccine-induced immune thrombotic thrombocytopenia (VITT). Using biophysical techniques, mouse models, and analysis of VITT patient samples, we identified de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f76a4e442ab525d6120a2decf8805622
https://doi.org/10.1182/blood.2021013231
https://doi.org/10.1182/blood.2021013231