Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Lea G. Stabinski"'
Morphological Changes in the Pituitary Gland of Dogs Chronically Exposed to Exogenous Growth Hormone
Autor:
Lea G. Stabinski, Matthew J. van Zwieten, Sylvain Molon-Noblot, Chennekatu P. Peter, Pierre Duprat, Srinivasa Prahalada, Philippe Laroque, Chao-Min Hoe
Publikováno v:
Toxicologic Pathology. 26:201-206
Growth hormone (GH) synthesis and release from the pituitary is regulated by hypothalamic releasing hormone, insulin-like growth factor-1 (IGF-1). and somatostatin. However, the potential effects of pharmacological doses of exogenous GH on the pituit
Autor:
Lea G. Stabinski, Philippe Laroque, Sylvain Molon-Noblot, Pierre Duprat, Srinivasa Prahalada, Matthew J. van Zwieten, Chennekatu P. Peter, Chao-Min Hoe
Publikováno v:
Toxicologic Pathology. 26:207-212
Administration of growth hormone (GH) results in increased body weight gain in dogs. Increased body weight gain is believed to be a result of the trophic effect of GH on the musculoskeletal system. However, edema is one of the side effects described
Autor:
Howard Y. Chen, Chennekatu P. Peter, Lea G. Stabinski, Dan Holder, Darryl H. Patrick, Srinivasa Prahalada, Richard E. Morrissey, Matthew J. van Zwieten, Georges De Burlet
Publikováno v:
Toxicologic Pathology. 26:185-200
The purpose of this study was to evaluate the pharmacological and toxicological effects of exogenous GH administration in normal adult dogs. Because porcine GH (pGH) is structurally identical to canine GH, pGH was selected for a 14-wk study in dogs.
Autor:
Srinivasa Prahalada, Chennekatu P. Peter, Lea G. Stabinski, Philippe Laroque, Sylvain Molon-Noblot, Matthew J. van Zwieten, Pierre Duprat
Publikováno v:
Toxicologic pathology. 28(4)
Porcine growth hormone was administered subcutaneously to beagle dogs at doses of 0.025,0.1, and 1 IU/kg/d for 14 weeks, markedly elevating serum growth hormone (GH) and insulin-like growth factor-1 (IGF-1) levels. This was accompanied by a significa