Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma

Autor: Giulia Anichini, Chiara Raggi, Mirella Pastore, Laura Carrassa, Luisa Maresca, Enrica Crivaro, Tiziano Lottini, Lea Duwe, Jesper B. Andersen, Lorenzo Tofani, Luca Di Tommaso, Jesus M. Banales, Annarosa Arcangeli, Fabio Marra, Barbara Stecca

Publikováno v: Anichini, G, Raggi, C, Pastore, M, Carrassa, L, Maresca, L, Crivaro, E, Lottini, T, Duwe, L, Andersen, J B, Tofani, L, Di Tommaso, L, Banales, J M, Arcangeli, A, Marra, F & Stecca, B 2023, ' Combined Inhibition of Smoothened and the DNA Damage Checkpoint WEE1 Exerts Antitumor Activity in Cholangiocarcinoma ', Molecular Cancer Therapeutics, vol. 22, no. 3, pp. 343-356 . https://doi.org/10.1158/1535-7163.MCT-22-0379

Cholangiocarcinoma (CCA) is characterized by resistance to chemotherapy and a poor prognosis. Therefore, treatments that can effectively suppress tumor growth are urgently needed. Aberrant activation of hedgehog (HH) signaling has been implicated in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3ae4357da40d93cadd71f28ce66a6e
https://doi.org/10.1158/1535-7163.mct-22-0379

Extracellular Signal‐Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells

Autor: Claudia Campani, Fabio Marra, Luca Di Tommaso, Mirella Pastore, Chiara Raggi, Alessandra Caligiuri, Domenico Alvaro, Alessandro Tubita, Sabina Di Matteo, A. Gentilini, Ignazia Tusa, N. Navari, Lea Duwe, Elisabetta Rovida, Tiziano Lottini, Jesper B. Andersen, Jesus M. Banales, S. Madiai, Annarosa Arcangeli, B. Piombanti, Giulia Lori, Giovanni Di Maira

Publikováno v: Gentilini, A, Lori, G, Caligiuri, A, Raggi, C, Di Maira, G, Pastore, M, Piombanti, B, Lottini, T, Arcangeli, A, Madiai, S, Navari, N, Banales, J M, Di Matteo, S, Alvaro, D, Duwe, L, Andersen, J B, Tubita, A, Tusa, I, Di Tommaso, L, Campani, C, Rovida, E & Marra, F 2021, ' Extracellular Signal-Regulated Kinase 5 Regulates the Malignant Phenotype of Cholangiocarcinoma Cells ', Hepatology, vol. 74, no. 4, pp. 2007-2020 . https://doi.org/10.1002/hep.31888
Hepatology (Baltimore, Md.)
Hepatology

Background and Aims: Cholangiocarcinoma (CCA) is characterized by high resistance to chemotherapy and poor prognosis. Several oncogenic pathways converge on activation of extracellular signal-regulated kinase 5 (ERK5), whose role in CCA has not been

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8475968afea93d14980baeb6481b75b
https://doi.org/10.1002/hep.31888

MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells

Autor: Lea Duwe, Patricia Munoz-Garrido, Monika Lewinska, Juan Lafuente-Barquero, Letizia Satriano, Dan Høgdall, Andrzej Taranta, Boye S. Nielsen, Awaisa Ghazal, Matthias S. Matter, Jesus M. Banales, Blanca I. Aldana, Yu-Tang Gao, Jens U. Marquardt, Lewis R. Roberts, Rui C. Oliveira, Jill Koshiol, Colm J. O'Rourke, Jesper B. Andersen

Publikováno v: Duwe, L, Munoz-Garrido, P, Lewinska, M, Lafuente-Barquero, J, Satriano, L, Høgdall, D, Taranta, A, Nielsen, B S, Ghazal, A, Matter, M S, Banales, J M, Aldana, B I, Gao, Y-T, Marquardt, J U, Roberts, L R, Oliveira, R C, Koshiol, J, O'Rourke, C J & Andersen, J B 2022, ' MicroRNA-27a-3p targets FoxO signalling to induce tumour-like phenotypes in bile duct cells ', Journal of Hepatology, vol. 78 . https://doi.org/10.1016/j.jhep.2022.10.012
Journal of Hepatology

Background & Aims: Cholangiocarcinoma (CCA) is a heterogeneous and lethal malignancy, the molecular origins of which remain poorly understood. MicroRNAs (miRs) target diverse signalling pathways, functioning as potent epigenetic regulators of transcr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92e66c0650516d2ceadf1aaae8cfc9a5
https://curis.ku.dk/portal/da/publications/microrna27a3p-targets-foxo-signalling-to-induce-tumourlike-phenotypes-in-bile-duct-cells(e2e06416-2bd3-4e90-9573-ab895519c481).html

Extracellular signal-regulated kinase 5 regulates the malignant phenotype of cholangiocarcinoma cells

Autor: Lea Duwe, Tiziano Lottini, C. Casini Raggi, Domenico Alvaro, S. Di Matteo, Antonio Taddei, Annarosa Arcangeli, Giulia Lori, G. Di Maira, Elisabetta Rovida, Jesper B. Andersen, Alessandra Caligiuri, Fabio Marra, Alessandro Tubita, S. Madiai, B. Piombanti, Mirella Pastore, Jesus M. Banales, A. Gentilini

Publikováno v: Digestive and Liver Disease. 53:S6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::777a0f9bfc1835581228f3d879e1c074
https://doi.org/10.1016/j.dld.2020.12.026