Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Lea Ann S. Kirkham"'
Autor:
Kelly M. Martinovich, Elke J. Seppanen, Amy S. Bleakley, Sharon L. Clark, Ross M. Andrews, Peter C. Richmond, Michael J. Binks, Ruth B. Thornton, Lea-Ann S. Kirkham
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
IntroductionChildren in low-mid income countries, and First Nations children in high-income countries, experience disproportionately high rates of Streptococcus pneumoniae and Haemophilus influenzae infections and diseases including pneumonia and oti
Externí odkaz:
https://doaj.org/article/1b60f63d453344de9439cb3cdd318d58
Autor:
Ruth B Thornton, Lea-Ann S Kirkham
Publikováno v:
Microbiology Australia, Vol 42, Iss 2, Pp 75-78 (2021)
Otitis media (OM; middle ear infection) is the most common reason for pre-school children to visit a doctor, be prescribed antimicrobials, or undergo surgery. Recent Cochrane reviews of clinical trials have identified that antibiotics and gromme
Externí odkaz:
https://doaj.org/article/f82b3a49f6b84a048f56b8b3015413c9
Autor:
Sharon L. Clark, Elke J. Seppanen, Lea-Ann S. Kirkham, Laura A. Novotny, Lauren O. Bakaletz, Allan W. Cripps, Karli Corscadden, Harvey Coates, Shyan Vijayasekaran, Peter C. Richmond, Ruth B. Thornton
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundNontypeable Haemophilus influenzae (NTHi) is the most common bacterial otopathogen associated with otitis media (OM). NTHi persists in biofilms within the middle ears of children with chronic and recurrent OM. Australian Aboriginal children
Externí odkaz:
https://doaj.org/article/0645a21149bd43f695372d7de5aeb56c
Autor:
Tulia Mateus, Elke J. Seppanen, Camilla de Gier, Sharon Clark, Harvey Coates, Shyan Vijayasekaran, Karen Prosser, Selma P. Wiertsema, Angela Fuery, Lea-Ann S. Kirkham, Peter C. Richmond, Ruth B. Thornton
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 12 (2022)
BackgroundThe underlying pathogenesis of pediatric obstructive sleep disordered breathing (SDB) and recurrent tonsillitis (RT) are poorly understood but need to be elucidated to develop less invasive treatment and prevention strategies.MethodsChildre
Externí odkaz:
https://doaj.org/article/79ae96ea025744a9b91117ef78c7687d
Autor:
Kelly M. Martinovich, Tasmina Rahman, Camilla de Gier, Elke J. Seppanen, Tilda Orami, Caitlyn M. Granland, Jacinta Francis, Mition Yoannes, Karli J. Corscadden, Rebecca Ford, Peter Jacoby, Anita H. J. van den Biggelaar, Lauren O. Bakaletz, Allan W. Cripps, Deborah Lehmann, Peter C. Richmond, William S. Pomat, Lea-Ann S. Kirkham, Ruth B. Thornton
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundDevelopment of vaccines to prevent disease and death from Streptococcus pneumoniae, and nontypeable Haemophilus influenzae (NTHi), the main pathogens that cause otitis media, pneumonia, meningitis and sepsis, are a global priority. Children
Externí odkaz:
https://doaj.org/article/cafa0af6b5974b4bafa7053ccea11c93
Autor:
Mejbah U. Bhuiyan, Christopher C. Blyth, Rachel West, Jurissa Lang, Tasmina Rahman, Caitlyn Granland, Camilla de Gier, Meredith L. Borland, Ruth B. Thornton, Lea-Ann S. Kirkham, Andrew Martin, Peter C. Richmond, David W. Smith, Adam Jaffe, Thomas L. Snelling
Publikováno v:
BMC Pulmonary Medicine, Vol 19, Iss 1, Pp 1-9 (2019)
Abstract Background Differentiating bacterial from viral pneumonia is important for guiding targeted management and judicious use of antibiotics. We assessed if clinical characteristics and blood inflammatory biomarkers could be used to distinguish b
Externí odkaz:
https://doaj.org/article/c778368903d549db9966dd8b8e8e79f2
Autor:
Mahmood F. Bhutta, Ruth B. Thornton, Lea-Ann S. Kirkham, Joseph E. Kerschner, Michael T. Cheeseman
Publikováno v:
Disease Models & Mechanisms, Vol 10, Iss 11, Pp 1289-1300 (2017)
Inflammation of the middle ear, known clinically as chronic otitis media, presents in different forms, such as chronic otitis media with effusion (COME; glue ear) and chronic suppurative otitis media (CSOM). These are highly prevalent diseases, espec
Externí odkaz:
https://doaj.org/article/e8395a177a2f4b80a7a39c1a97548775
Autor:
Elke J Seppanen, Ruth B Thornton, Karli J Corscadden, Caitlyn M Granland, Julie Hibbert, Angela Fuery, Selma P Wiertsema, Shyan Vijayasekaran, Harvey L Coates, Peter Jacoby, Andrew Currie, Peter C Richmond, Lea-Ann S Kirkham
Publikováno v:
PLoS ONE, Vol 14, Iss 12, p e0227080 (2019)
Recurrent and chronic otitis media (OM) are often refractory to antibiotics due to bacterial persistence in biofilm within the middle ear. In vitro and in vivo studies have demonstrated that antimicrobial proteins and peptides (AMPs) are bactericidal
Externí odkaz:
https://doaj.org/article/7584fa9e659047ddacefbfa91adbf024
Autor:
Elke Seppanen, Dino Tan, Karli J Corscadden, Andrew J Currie, Peter C Richmond, Ruth B Thornton, Lea-Ann S Kirkham
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0193962 (2018)
Otitis media (OM) remains a common paediatric disease, despite advances in vaccinology. Susceptibility to recurrent acute OM (rAOM) has been postulated to involve defective cell-mediated immune responses to common otopathogenic bacteria. We compared
Externí odkaz:
https://doaj.org/article/a7f923c2e81c48e785563c0713b89e51
Autor:
Rebecca Ford, Elke J. Seppanen, Camilla de Gier, Jacinta Francis, Tilda Orami, Karli J. Corscadden, William Pomat, Audrey Michael, Mition Yoannes, Lea Ann S. Kirkham, Caitlyn Granland, Peter Jacoby, Ruth B. Thornton, Tasmina Rahman, Deborah Lehmann, K. Martinovich, Anita H. J. van den Biggelaar, Peter Richmond
Publikováno v:
Vaccine. 39:3486-3492
Background Nasopharyngeal colonisation with nontypeable Haemophilus influenzae (NTHi) is associated with development of infections including pneumonia and otitis media. The 10-valent pneumococcal conjugate vaccine (PCV10) uses NTHi Protein D (PD) as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc84f71dbad7dfa7df42c1134d12c97a
https://doi.org/10.1016/j.vaccine.2021.05.022
https://doi.org/10.1016/j.vaccine.2021.05.022