The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor

Autor: Reggie Bosma, Gesa Witt, Lea A. I. Vaas, Ivana Josimovic, Philip Gribbon, Henry F. Vischer, Sheraz Gul, Rob Leurs

Publikováno v: Frontiers in Pharmacology, Vol 8 (2017)

The pharmacodynamics of drug-candidates is often optimized by metrics that describe target binding (Kd or Ki value) or target modulation (IC50). However, these metrics are determined at equilibrium conditions, and consequently information regarding t

Externí odkaz: https://doaj.org/article/bde3d59b95ed40549fe2902e6b1946ab

Dining in Blue Light Impairs the Appetite of Some Leaf Epiphytes

Autor: Maria E. Karlsson, Anna Karin Rosberg, Samareh Gharaie, Sofia Windstam, Walter Wohanka, Sammar Khalil, Beatrix Alsanius, Lea A. I. Vaas

Publikováno v: Frontiers in Microbiology, Vol 12 (2021)
Frontiers in Microbiology

Background: The phyllosphere is subjected to fluctuating abiotic conditions. This study examined the phenotypic plasticity (PP) of four selected non-phototrophic phyllosphere bacteria [control strain: Pseudomonas sp. DR 5-09; Pseudomonas agarici, Bac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39fec5f2697739e4536413263582d6a6

Visualization and curve-parameter estimation strategies for efficient exploration of phenotype microarray kinetics.

Autor: Lea A I Vaas, Johannes Sikorski, Victoria Michael, Markus Göker, Hans-Peter Klenk

Publikováno v: PLoS ONE, Vol 7, Iss 4, p e34846 (2012)

BackgroundThe Phenotype MicroArray (OmniLog® PM) system is able to simultaneously capture a large number of phenotypes by recording an organism's respiration over time on distinct substrates. This technique targets the object of natural selection it

Externí odkaz: https://doaj.org/article/2f4706e21ded4edba4b58d433599b02e

The rat bone marrow micronucleus test: Statistical considerations on historical negative control data

Autor: Steffi Chang, Martina Dammann, Christina Ziemann, Nina Queisser, Annette Bitsch, Lea A. I. Vaas, Marlies Nern, Roland Frötschl, Richardus Vonk, Stefan Pfuhler, Dietmar Zellner, Volker Krzykalla, Bernd-Wolfgang Igl, Volker Harm, Frank Bringezu, Markus Schulz, Jasmin Lott, Andreas Sutter, Rupert Kellner

Publikováno v: Regulatory toxicology and pharmacology : RTP. 102

Recent updates of the OECD Guidelines for the Testing of Chemicals (Section 4: Health Effects) on genotoxicity testing emphasize the use of appropriate statistical methods for data analysis and proficiency proof. Updates also concern the mammalian er

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be01db78c067da127a724c301269da73
https://pubmed.ncbi.nlm.nih.gov/30572081

Making sense of big data in health research: {T}owards an {EU} action plan

Autor: Haralampos Karanikas, Shahid Hanif, Henk-Jan Guchelaar, Enrique Bernal-Delgado, Bertrand Pedersen, Ana Conesa, Ivo Gut, Paul Flicek, Juan Antonio Vizcaíno, Christoph Bock, Tim Hubbard, Milan Petkovic, Edith Maes, John Peter Mary Wubbe, Sophie Helen Janacek, Werner Müller, Norbert Graf, Josep Redón Más, Xavier Serra-Picamal, Pablo Villoslada, Okker van Batenburg, Alberto Di Meglio, Marinus J.C. Eijkemans, Reinhard Schneider, Konstantinos Pliakos, Susanna Del Signore, Christophe Delogne, Ralf-Dieter Hilgers, Charles Auffray, László Bencze, Yike Guo, Vera Grimm, D. Rod Hose, Lea A. I. Vaas, Allan Hanbury, Péter Várnai, Andreas Kremer, Manfred Kohler, Mikael Benson, Thomas Lengauer, Angel Honrado, Rudi Balling, Peter Devilee, Gianluigi Zanetti, Jay M. Bergeron, Inês Barroso, Niklas Blomberg, Theo Meert, Marc Vandelaer, Magnus Rattray, Peter Oledzki, Dörthe Nickel, Thierry Sengstag, Wouter Spek, Tim Kievits, Jeanine J. Houwing-Duistermaat, Jerry Lanfear

Publikováno v: Genome medicine 8, 71 (2016). doi:10.1186/s13073-016-0323-y
Genome medicine, 8(1), 71. England (2016).
Genome Medicine
Genome Medicine, 8. BIOMED CENTRAL LTD
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Genome Medicine, 8. BioMed Central
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Auffray, C, Balling, R, Barroso, I, Bencze, L, Benson, M, Bergeron, J, Bernal-Delgado, E, Blomberg, N, Bock, C, Conesa, A, Del Signore, S, Delogne, C, Devilee, P, Di Meglio, A, Eijkemans, M, Flicek, P, Graf, N, Grimm, V, Guchelaar, H-J, Guo, Y-K, Gut, I G, Hanbury, A, Hanif, S, Hilgers, R-D, Honrado, Á, Hose, D R, Houwing-Duistermaat, J, Hubbard, T, Janacek, S H, Karanikas, H, Kievits, T, Kohler, M, Kremer, A, Lanfear, J, Lengauer, T, Maes, E, Meert, T, Müller, W, Nickel, D, Oledzki, P, Pedersen, B, Petkovic, M, Pliakos, K, Rattray, M, I Màs, J R, Schneider, R, Sengstag, T, Serra-Picamal, X, Spek, W, Vaas, L A I, van Batenburg, O, Vandelaer, M, Varnai, P, Villoslada, P, Vizcaíno, J A, Wubbe, J P M & Zanetti, G 2016, ' Making sense of big data in health research : Towards an EU action plan ', Genome Medicine, vol. 8, no. 1, pp. 71 . https://doi.org/10.1186/s13073-016-0323-y
r-CIPF: Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
Centro de Investigación Principe Felipe (CIPF)
Auffray, C, Balling, R, Barroso, I, Bencze, L, Benson, M, Bergeron, J, Bernal-Delgado, E, Blomberg, N, Bock, C, Conesa, A, Del Signore, S, Delogne, C, Devilee, P, Di Meglio, A, Eijkemans, M, Flicek, P, Graf, N, Grimm, V, Guchelaar, H J, Guo, Y K, Gut, I G, Hanbury, A, Hanif, S, Hilgers, R D, Honrado, Á, Hose, D R, Houwing-Duistermaat, J, Hubbard, T, Janacek, S H, Karanikas, H, Kievits, T, Kohler, M, Kremer, A, Lanfear, J, Lengauer, T, Maes, E, Meert, T, Müller, W, Nickel, D, Oledzki, P, Pedersen, B, Petkovic, M, Pliakos, K, Rattray, M, i Màs, J R, Schneider, R, Sengstag, T, Serra-Picamal, X, Spek, W, Vaas, L A I, van Batenburg, O, Vandelaer, M, Varnai, P, Villoslada, P, Vizcaíno, J A, Wubbe, J P M & Zanetti, G 2016, ' Making sense of big data in health research : Towards an EU action plan ', Genome medicine, vol. 8, no. 1, 71 . https://doi.org/10.1186/s13073-016-0323-y
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Genome medicine 8(1), 71 (2016). doi:10.1186/s13073-016-0323-y
Published by BioMed Central, London

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ea35d66d6273371037ebcdaa6e9b78d
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-130277