Ephrin/Eph receptor interaction facilitates macrophage recognition of differentiating human erythroblasts

Autor: Lea A. Hampton-O’Neil, Charlotte E. Severn, Stephen J. Cross, Sonam Gurung, Catherine D. Nobes, Ashley M. Toye

Publikováno v: Haematologica, Vol 105, Iss 4 (2020)

Erythropoiesis is one of the most efficient cellular processes in the human body producing approximately 2.5 million red blood cells every second. This process occurs in a bone marrow niche comprised of a central resident macrophage surrounded by dif

Externí odkaz: https://doaj.org/article/ee737b45d7ac447fbdec973b09087dda

Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages

Autor: Ashley M. Toye, Stephen Cross, Floris P. J. van Alphen, Lea A Hampton-O’Neil, Esther Heideveld, Maartje van den Biggelaar, Emile van den Akker

Publikováno v: Heideveld, E, Hampton-O'Neil, L, Cross, S, van Alphen, F P J, van den Biggelaar, M, Toye, A & Van den Akker, E 2018, ' Glucocorticoids induce differentiation of monocytes towards macrophages that share functional and phenotypical aspects with erythroblastic island macrophages ', Haematologica, vol. 103, no. 3, pp. 395-405 . https://doi.org/10.3324/haematol.2017.179341
Haematologica, 103(3), 395-405. Ferrata Storti Foundation
Haematologica

The classical central macrophage found in erythroblastic islands plays an important role in erythroblast differentiation, proliferation and enucleation in the bone marrow. Convenient human in vitro models to facilitate the study of erythroid-macropha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::658dfe3ba45ae0e31813970619b6885b
https://doi.org/10.3324/haematol.2017.179341

PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton

Autor: Lea A Hampton-O’Neil, Elaine V. Hill, Danielle J Clark, Kerrie E. McNally, Catherine A Sabatos-Peyton, Philomena Butterweck, Christoph Wülfing, Rachel Ambler, Graham J. Britton, Paul Verkade, Helen M Tunbridge, David C. Wraith, Bronwen R Burton

Publikováno v: eLife
Britton, G, Ambler, R C J, Clark, D, Hill, E, Tunbridge, H, McNally, K, Burton, B, Butterweck, P, Sabatos-Peyton, C, Hampton-O'Neil, L, Verkade, P, Wuelfing, C & Wraith, D 2017, ' PKCθ links proximal T cell and Notch signaling through localized regulation of the actin cytoskeleton ', eLife, vol. 6, e20003 . https://doi.org/10.7554/eLife.20003
eLife, Vol 6 (2017)

Notch is a critical regulator of T cell differentiation and is activated through proteolytic cleavage in response to ligand engagement. Using murine myelin-reactive CD4 T cells, we demonstrate that proximal T cell signaling modulates Notch activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41da55c70246aa5db4146ad1dcf029b1
http://europepmc.org/articles/PMC5310840