Výsledky vyhledávání - "Lea, Maillat"

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

Autor: Aymeric Auger, Laura Santambrogio, Patricia Corthésy, Davide Demurtas, Emanuela Romano, Melody A. Swartz, Lambert Potin, Maurice Matter, Cristina C. Clement, Romain Hamelin, Alexandre Harari, Daniel E. Speiser, Natacha Bordry, Lea Maillat, Maria A. S. Broggi

Publikováno v: The Journal of Experimental Medicine
The Journal of experimental medicine, vol. 216, no. 5, pp. 1091-1107

Identifying cancer biomarkers is of great interest for patient prognosis and monitoring. However, tumor-associated factors are diluted in blood and challenging to detect. Broggi et al. show that lymphatic exudate, accessible at the time of lymphadene

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18f6806c0790a1e5f776aeca52a5a9a1
http://europepmc.org/articles/PMC6504224

Zobrazit plný text záznamu

Abstract 1685: PARP/PI3K inhibitor combination therapy eradicates c-MYC-driven murine prostate cancers via cGAS/STING pathway activation within tumor-associated macrophages

Autor: Sweta Sharma-Saha, Yamuna Krishnan, Lea Maillat, Kaela Bynoe, Walter M. Stadler, Brian L. Heiss, Priyanka Dutta Gupta, Kiranj K. Chaudagar, Ka-Ho Leung, Akash Patnaik

Publikováno v: Cancer Research. 81:1685-1685

There has been a resurgent interest in prostate cancer (PC) immunotherapy, partly based on the profound and durable clinical responses to immune checkpoint blockade (ICB) antibodies targeting CTLA-4 and PD-1/PD-L1 in multiple other cancers, and partl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dedfdb23262067c79ea6498608d3d8f
https://doi.org/10.1158/1538-7445.am2021-1685

Zobrazit plný text záznamu

Prolonged residence of an albumin-IL-4 fusion protein in secondary lymphoid organs ameliorates experimental autoimmune encephalomyelitis

Autor: Ako, Ishihara, Jun, Ishihara, Elyse A, Watkins, Andrew C, Tremain, Mindy, Nguyen, Ani, Solanki, Kiyomitsu, Katsumata, Aslan, Mansurov, Erica, Budina, Aaron T, Alpar, Peyman, Hosseinchi, Lea, Maillat, Joseph W, Reda, Takahiro, Kageyama, Melody A, Swartz, Eiji, Yuba, Jeffrey A, Hubbell

Publikováno v: Nature biomedical engineering. 5(5)

Interleukin-4 (IL-4) suppresses the development of multiple sclerosis in a murine model of experimental autoimmune encephalomyelitis (EAE). Here, we show that, in mice with EAE, the accumulation and persistence in the lymph nodes and spleen of a syst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::68c43e02287c4911b22431ceb429eeff
https://pubmed.ncbi.nlm.nih.gov/33093659

Zobrazit plný text záznamu

Abstract 5695: Induction of lymphangiogenesis in breast cancer enhances responsiveness to immunotherapies

Autor: Gavin Fujimori, Aslan Mansurov, Jeffrey A. Hubbell, Melody A. Swartz, Peyman Hosseinchi, Lambert Potin, Lea Maillat

Publikováno v: Cancer Research. 80:5695-5695

Growth and remodeling of tumor-associated lymphatics, termed lymphangiogenesis, has been known to increase metastasis rate in cancer patients. However, a recent study from our group has shown that tumor-associated lymphatics can improve anti-tumor im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fec84d786f35613fe52ec6d21f0fa18b
https://doi.org/10.1158/1538-7445.am2020-5695

Zobrazit plný text záznamu

Abstract B97: The immunomodulatory roles of tumor-associated lymphatics in triple-negative breast cancer

Autor: Jeffrey A. Hubbell, Lea Maillat, Lambert Potin, Peyman Hosseinchi, Melody A. Swartz, Aslan Mansurov

Publikováno v: Cancer Immunology Research. 8:B97-B97

During cancer development, growth and remodeling of lymphatic vessels—termed lymphangiogenesis—is associated with increased metastasis rate. However, our group has recently shown that lymphangiogenesis can also increase tumor immune infiltration

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c931762b96268db0f97285c8c7f6d6e5
https://doi.org/10.1158/2326-6074.tumimm19-b97

Zobrazit plný text záznamu

Abstract 4520: Lymphatic vessels regulate exosome trafficking from tumors

Autor: Lea Maillat, Lambert Potin, Witold W. Kilarski, Melody A. Swartz

Publikováno v: Cancer Research. 79:4520-4520

Prior to metastasis, tumor-draining lymph nodes and distant organs are altered by a number of tumor-derived factors that help to both suppress host immunity as well as form an environment that supports metastatic tumor cells, i.e., a pre-metastatic n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fd3f5dd4378c601e9a628e8f22b21a2c
https://doi.org/10.1158/1538-7445.am2019-4520

Zobrazit plný text záznamu

Abstract 1750: Inducing therapeutic lymphangiogenesis for potentiating cancer immunotherapy in melanoma

Autor: Jeffrey A. Hubbell, Melody A. Swartz, Lea Maillat, Priscilla S. Briquez, Lambert Potin

Publikováno v: Cancer Research. 78:1750-1750

Tumor-associated lymphangiogenesis is well known to promote metastasis and to correlate with poor prognosis in melanoma and other cancers, yet its functional roles in antitumor immunity had remained largely unexplored. In a recent study, we investiga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e29b7c09505117f69be1a57ba3e23ba4
https://doi.org/10.1158/1538-7445.am2018-1750

Zobrazit plný text záznamu

The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation

Autor: Tao Sun, Joel H. Collier, Rebecca R. Pompano, Jianjun Chen, Anita S. Chong, Felix W. Santiago, Huifang Han, Roger Sciammas, David J. Topham, Lea Maillat

Publikováno v: Biomaterials, vol 34, iss 34

Balancing immunogenicity with inflammation is a central tenet of vaccine design, especially for subunit vaccines that utilize traditional pro-inflammatory adjuvants. Here we report that by using a nanoparticulate peptide-based vaccine, immunogenicity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3fede2e6446af197dfa99a38df7008b
https://pubmed.ncbi.nlm.nih.gov/23953841

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání